Life Cycle Inventory and Assessment Datasets on the Operational Sustainability of the Ammonia Process.

This article presents data affiliated with life cycle inventories, environmental impact and operational sustainability used in, the influence of raw material availability and utility power consumption on the sustainability of the ammonia process [1]. Scenario specific operating conditions were used to simulate the ammonia process based on unique constraints occurring within the Trinidad and Tobago energy sector. The data was collected using AspenⓇ Plus simulations and validated against plant operating data. The data consists of an economic cost evaluation as well as environmental impact using the CML-IA Baseline midpoint approach. The data was derived from life cycle inventories aligned to input/output material and energy flows within the ammonia process as well as life cycle assessment databases utilizing Ecoinvent v3.4. The data can be applied to the wider ammonia supply chain, aiding in achieving greater sustainable development within ammonia-based process industries.

Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.

The caliber and magnitude of T cell responses are regulated by costimulatory molecules following the engagement of TCRs and MHC molecules. B7-DC has the highest homology with B7-H1 in the B7 family, and both of them bind an immunoregulatory molecule, programmed death 1. Previous studies have demonstrated that B7-DC stimulates T cell proliferation and CTL generation, which sharply contrasts the inhibitory role of B7-H1. Th2 cytokines prompt B7-DC expression, which in turn enhances Th1 responses. In this study, we used an intestinal nematode, Nippostrongylus brasiliensis, to induce strong Th2 responses and to evaluate B7-DC function under Th2-polarizing conditions in vivo. By either blocking B7-DC expression during N. brasiliensis infection or by examining N. brasiliensis-infected B7-DC knockout mice, we observed enhanced eosinophilia, the overproduction of serum IgE, and increased Th2 cytokine production along with decreased Th1 cytokine production (particularly IFN-gamma production), indicating that B7-DC inhibits Th2 responses. Our results further demonstrate that the inhibition of Th2 responses by B7-DC occurs independently of programmed death 1 but conceivably acts through an as yet unknown alternative receptor that enhances Th1 responses. Although the deficiency of B7-DC expression that enhanced the production of IL-13 paradoxically resulted in better protection against N. brasiliensis infection, our results show that B7-DC plays an important role in bolstering a robust Th1 response that is required for effective antiviral and anticancer immunity, even under a strong Th2-polarizing environment induced by N. brasiliensis infection.