ABSTRACT
BACKGROUND: No data are currently available on immunogenicity of higher-valent pneumococcal conjugate vaccines when co-administered with a 4-component meningococcal serogroup B vaccine (4CMenB). METHODS: Post-hoc analysis of pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) immunogenicity when co-administered with 4CMenB (2â¯+â¯1 schedule) and/or a CRM-conjugated meningococcal serogroup C vaccine (MenC-CRM) in a trial assessing 4CMenB reduced schedules and co-administration with MenC-CRM (NCT01339923). Infants were randomized to receive 4CMenB and MenC-CRM (Group 1) or MenC-CRM (Group 2) at 3, 5, and 12â¯months (M) of age. Both groups received PHiD-CV (3â¯+â¯1 schedule) as part of the Brazilian national immunisation programme at 3â¯M, 5â¯M, 7â¯M, and 12â¯M of age. Antibody responses were assessed pre-vaccination, 1â¯M post-dose 2, pre-booster, and 1â¯M post-booster. RESULTS: Anti-pneumococcal antibody responses were in similar ranges in the two study groups. CONCLUSIONS: 4CMenB co-administration did not seem to impact antibody responses to PHiD-CV in infants.