Green synthesis of silver doped zinc oxide/magnesium oxide nanocomposite for waste water treatment and examination of their cytotoxicity properties.

This research attempted to prepare silver-doped zinc oxide/magnesium oxide nanocomposite (Ag-doped ZnO/MgO-NCP) using Mentha pulegium plant extract. The synthesized NCP was investigated by X-ray diffraction analysis (XRD), Fourier Transform Infrared (FT-IR), Field Emission Scanning Electron Microscope (FESEM), Energy dispersive X-ray spectroscopy (EDX), Mapping, and UV-Visible analyses. The XRD data displayed cubic crystal structures for silver & magnesium oxide and a hexagonal framework for zinc oxide. Also, FESEM and PSA images of NCP pointed out, that the average size of the spherical morphology is about 10-16 nm, while the analysis of EDX confirmed the attendance of Zn, Mg, Ag, and O elements. Under UVA light, we tested the photocatalytic activity of NCP to the degradation of Methylene blue (MB) and Rhodamine B (RhB) dyes in various temperatures (400, 500, and 600 °C). The results of the photocatalytic test displayed that the degradation percentage of MB dye in pH = 9, nanocomposite amount ∼30 mg, and dye concentration ∼1 × 10 -5 M was about 98 %. We also evaluated the cytotoxicity of nanocomposite on cancer CT-26 cell line through the MTT method and obtained an IC50 value of 250 µg/mL.

A green and facile approach for fabrication of biocompatible anti-Parkinson chitosan-gelatin-green tea extract composite particles with neuroprotective and Neurotherapeutic effects: In vitro evaluation.

The design and fabrication of bio-inspired materials are valuable for the treatment of Parkinson's disease (PD) due to their remarkable antioxidant properties, biocompatibility, and minor side effects. In this study, novel biocompatible and biodegradable chitosan-gelatin-green tea extract (CS-Gel-GTE) composite particles were fabricated with excellent antioxidant properties for therapeutic purposes in PD. An innovative angle-dependent electrospray system fabricated CS-Gel-GTE composite particles in only 1 min using a single-step method. The composite particles were investigated using various characterization methods. In addition to being facile and cost-effective, our methodology resulted in the formation of particles with a prolonged release time of nine days for GTE with a pH of 7.4. A cellular study was also performed to investigate the composite particles' cell viability and neuroprotective effects. The results showed enhanced cell viability and a significant reduction in cell apoptosis. In addition, the synthesized biomaterials showed the potential to inhibit the formation of reactive oxygen species (ROS), increase tyrosine hydroxylase (TH) enzyme expression and decrease α-syn protein expression. Overall, this study offers exquisite natural biomaterials for PD treatment.