Research progress on P2X7 receptor in cancer pain / 基础医学与临床

The activation of the P2X7 receptor as an ATP-gated ion channel,triggers the release of pro-inflammato-ry cytokines in tumor carring individuals and stimulate excitation of injury-causing neurons,thereby exacerbating the transmission of pain.In preclinical cancer pain models,it has the potential to serve as a new therapeutic target for cancer pain management.

Related risk factors and clinical treatment of patients with PGS after gastric cancer operation / 吉林大学学报(医学版)

Objective: To investigate the reasons for the occurrence of postsurgical gastroparesis syndrome (PGS) in the patients with gastric cancer after gastric cancer operation, and to elucidate the related risk factors and treatment measures for the PGS patients, and to provide the basis for improving the quality of life of the patients with PGS. Methods: The clinical data of 1 015 patients underwent radical gastrectomy were retrospectively analyzed and the patients were divided into PGS group (n=39) and non-PGS group ("=976) according to whether the PGS appeared after operation. Single factor analysis was performed according to age, gender, surgical method and anastomosis in the patients in two groups. The risk factors related to PGS were analyzed. Results, There was no difference in the incidence of PGS in the patients ≥56 years old and the patients 0. 05), the incidence of PGS in the male patients was not significantly different from that in the female patients (P>0. 05); the incidence of PGS in the patients underwemt radical gastrectomy was higher than that in the patients underwent laparoscopic radical gastrectomy (P<0. 01), the incidence of PGS in the patients underwent Billroth I anastomosis was lower than that in the patients underwent Billroth II anastomosis (P<0. 01). All the PGS patients were cured after treated with a combination method of drugs and p sychology. Conclusion: The occurrence of PGS after radical gastrectomy has nothing to do with the physiological factors of the patients such as gender and age. The incidence of PGS after laparoscopic radical gastrectomy is lower than that after open radical gastrectomy, and the incidence of PGS after Billroth I anastomosis is lower than that after Billroth II anastomosis.