ABSTRACT
A considerable number of end-stage renal disease patients undergo tunneled cuffed catheter insertion for hemodialysis under ultrasonographic guidance while awaiting arteriovenous fistula creation. We report a case of a 62-year-old female who underwent tunneled catheter insertion in the left internal jugular vein under ultrasound and fluoroscopic guidance, which was followed by pericatheter serous discharge. Fluid examination confirmed the diagnosis of lymphorrhea, and lymphoscintigraphy facilitated its localization. This case is reported for its rarity and with a discussion on literature review, complications of lymphorrhea, and their management.
ABSTRACT
Although percutaneous renal biopsy remains the preferred method, there are several scenarios where transjugular approach is more suitable. We hereby describe our technique of transjugular renal biopsy (TJRB) and evaluate its safety and efficacy. We retrospectively collected data regarding indication for the transjugular route of biopsy, its complications, clinical and laboratory data, and adequacy of samples from patients' records. TJRB was performed when the patients were at a high risk for bleeding from percutaneous renal biopsy. Tissue samples were assessed by a pathologist for adequacy. All patients were followed up with ultrasonographic scan 3 h after the procedure and on day 3. Nine patients (age 41.5 ± 15.4 years; 8 men) underwent 9 TJRB procedures. The procedure was technically successful in all patients. Six patients (66.67%) had a platelet count of <50,000/mcL, 2 (33.3%) had an elevated International Normalized Ratio of more than 1.4, and 1 had both. 3.2 ± 0.4 cores were obtained, with median (range) number of glomeruli being ten (7-11). Adequate renal tissue sample was obtained in all the patients. Though capsular perforation developed in 5 patients, none had major complication requiring management (endovascular treatment or blood transfusion). TJRB is a safe and effective in patients with contraindications to percutaneous biopsy.
ABSTRACT
A forty two year old male was admitted with history of anuria and breathlessness following consumption of raw rohu fish gall bladder. He had azotemia and required hemodialysis. His renal failure improved over a period of about four weeks. Incidences have been reported from South East Asian countries associating consumption of raw rohu fish gall bladder with acute renal failure.
Subject(s)
Acute Kidney Injury/etiology , Carps , Foodborne Diseases/complications , Gallbladder , Acute Kidney Injury/diagnosis , Acute Kidney Injury/therapy , Adult , Animals , Azotemia/complications , Fishes , Humans , Male , Renal Dialysis , Treatment OutcomeSubject(s)
Nephrology/history , Physicians, Women , History, 20th Century , History, 21st Century , Humans , IndiaABSTRACT
Fusarium is a filamentous opportunistic pathogenic fungus responsible for superficial as well as invasive infection in immunocompromized hosts. Net state of immunosuppression and cytomegalovirus (CMV) infection appear to predispose to this disease which is life-threatening when disseminated. Though infections with Fusarium have been widely described in hematological malignancies and hematopoietic stem cell transplant cases, they have been reported to be rare in solid organ transplant recipients, are often localized and carry a favorable prognosis. We here describe a rare case of subcutaneous non-invasive infection with Fusarium in a renal allograft recipient two and half years after transplantation. Patient had a previous history of CMV infection along with multiple other recurrent co-infections. Diagnosis was based on culture of tissue specimens yielding Fusarium species. The infection had a protracted course with persistence of lesions after treatment with voriconazole alone, requiring a combination of complete surgical excision and therapy with the anti-fungal drug.
Subject(s)
Fusariosis/diagnosis , Fusarium/isolation & purification , Hyalohyphomycosis/microbiology , Postoperative Complications/microbiology , Adult , Female , Fusariosis/therapy , Humans , Hyalohyphomycosis/diagnosis , Hyalohyphomycosis/therapy , Kidney Transplantation , Postoperative Complications/diagnosis , Postoperative Complications/therapyABSTRACT
We report a case of hemolytic uremic syndrome (HUS) in an adult patient with Plasmodium vivax malaria. The patient presented with worsening anemia, persistent thrombocytopenia and acute kidney injury. HUS was diagnosed based on the high serum lactate dehydrogenase, elevated reticulocyte count and presence of schistocytes on peripheral blood smear. Kidney biopsy showed features of thrombotic microangiopathy. Complete hematological remission was achieved after five sessions of therapeutic plasma exchange. Renal function partially recovered and stabilized at discharge. Vivax malaria, generally considered benign, may be rarely associated with HUS.
ABSTRACT
We report here a case of 26-year-old male who presented with history of recurrent acute renal failure associated with microangiopathic hemolytic anemia and thrombocytopenia. ADAMTS 13 deficiency due to mutation in the gene encoding for ADAMTS 13 was identified as the cause. After eight episodes of acute kidney injury (AKI), patient started developing hypertension, proteinuria, and renal insufficiency. Treatment with regular monthly plasma infusions prevented further episodes of AKI and stabilized the renal function. Hypertension and proteinuria are controlled with angiotensin II receptor blockers.
ABSTRACT
An optical biosensing scheme based on urease encapsulated calcium alginate microspheres which are coated with polyelectrolyte nanofilms predominantly composed of cresol red (CR) dye is demonstrated in this paper. The dye molecules within the nanofilms are deposited via the layer-by-layer (LbL) self-assembly technique on the microspheres and used as the optical transducer. A flow through cell constructed using a cuvette attached to a fiber optic spectrometer was used to determine the response of the biosensor to standard urea solutions of different concentrations. The change in pH and the absorbance ratio was monitored with time and these results were used for measurements of urea concentrations in the spent dialysate fluid. The biological parameters controlling hemodialysis such as dialyzer clearance or Kt/V and percent removed urea (PRU) have also been reported. The results demonstrate that the urea biosensor is pH reversible with a sensitivity of 0.09 pH units/min and is able to detect a change of 0.005 ratio units in urea concentration ranging 0.1-60 mg dL(-1). The response time of the sensor was calculated as 8 min while the detection range of urea covered the levels that are present in the spent dialysate fluid. The results obtained in the analysis of biological samples were in good agreement with those obtained by a reference method, showing no significant differences at a confidence level of 95%.
Subject(s)
Biosensing Techniques/methods , Dialysis Solutions/chemistry , Nanotechnology/methods , Urea/analysis , Alginates/chemistry , Glucuronic Acid/chemistry , Hexuronic Acids/chemistry , Hydrogen-Ion Concentration , Microspheres , Phenolsulfonphthalein/analogs & derivatives , Phenolsulfonphthalein/chemistry , Renal Dialysis , Urease/metabolismABSTRACT
Primary hyperoxaluria is a rare autosomal recessive disease due to deficiency of an oxalate-metabolizing liver enzyme, which results in nephrolithiasis and renal failure. Concomitant liver and kidney transplant is recommended as isolated kidney transplant is inevitably complicated by recurrence of the disease. We present a 25-year-old man with end-stage nephrolithiatic renal disease who underwent bilateral nephrectomy, followed by kidney transplantation. There was progressive worsening of kidney function two weeks post transplant. Review of nephrectomy and transplant kidney biopsy showed abundant calcium oxalate crystals and further workup revealed hyperoxaluria, which was previously unsuspected. Later he developed fever, breathlessness, hemiparesis and died 10 weeks after transplant. Autopsy revealed multi-organ deposits of oxalate crystals as well as widespread zygomycosis. This case emphasizes the need for careful pre-transplant evaluation of patients with renal calculus disease in order to exclude primary hyperoxaluria.
Subject(s)
Calcium Oxalate/urine , Hyperoxaluria, Primary/etiology , Kidney Failure, Chronic/complications , Kidney Transplantation/adverse effects , Adult , Fatal Outcome , Humans , Hyperoxaluria, Primary/pathology , Hyperoxaluria, Primary/surgery , Kidney Failure, Chronic/pathology , Kidney Failure, Chronic/surgery , Male , RecurrenceABSTRACT
OBJECTIVE: 1) The aim of the study was to identify the atypical celiac disease (CD) in a cohort of symptomatic osteoporotic patients, younger than 55 years of age and 2) To study associated clinical and laboratory features and outcome with gluten-free diet. MATERIAL AND METHODS: We studied 33 patients (F:M = 28:5), mean age 29 years (range 15-52 years) with osteoporosis (WHO diagnostic criteria, T-score less than -2.5 on DEXA scan) from January 2000 - June 2002. Serological screening for CD was done by detecting circulating IgA antibodies to tissue transglutaminase by ELISA. Patients with presence of antibodies to transglutaminase were subjected to biopsy from the 2nd part of the duodenum by upper GI endoscopy. The biopsies were reported independently by two pathologists who were blinded for the serology report. Measurement of mucosal thickness, crypts and villi were done with an ocular micrometer. Other parameters like complete hemogram, serum iron, total iron binding capacity (TIBC), calcium profile, 25-OH-D, parathyroid hormone (PTH) were evaluated. Assessment of clinical and laboratory parameters was performed within 4-12 weeks of starting gluten-free diet (GFD). RESULTS: Thirteen patients had circulating IgA antibodies to transglutaminase. Intestinal biopsies were performed on 11 patients and were consistent with the diagnosis of CD (total villous atrophy--two, subtotal villous atrophy with crypt hyperplasia--nine). Patients with CD had significant anaemia when compared with non-CD osteoporotic patients. Other important observations in these 11 patients were low serum calcium and phosphorus, low 25-OH-D, high PTH. Significant improvement in clinical and laboratory parameters was noted in all patients within 6-12 weeks of starting GFD. CONCLUSION: Symptomatic osteoporotic patients (younger than 55 years of age) especially with associated anaemia should be investigated for CD. Simple measures like omission of wheat from diet (GFD) lead to significant improvement in symptoms within weeks.
Subject(s)
Celiac Disease/diagnosis , Osteoporosis/etiology , Adolescent , Adult , Celiac Disease/complications , Celiac Disease/pathology , Duodenum/pathology , Female , Humans , Intestinal Mucosa/pathology , Male , Middle AgedABSTRACT
We report a case of quadriplegia complicating ossification of posterior longitudinal ligament (OPLL) in a patient who was also found to have diffuse idiopathic skeletal hyperostosis (DISH). She also had osteomalacia (Vit. D deficiency) with secondary hyperparathyroidism. There could be a cause and effect relationship between the abnormal biochemistry and OPLL.
Subject(s)
Hyperostosis, Diffuse Idiopathic Skeletal/complications , Ossification of Posterior Longitudinal Ligament/etiology , Osteomalacia/complications , Quadriplegia/complications , Adult , Diskectomy , Female , Humans , Hyperostosis, Diffuse Idiopathic Skeletal/diagnostic imaging , Ossification of Posterior Longitudinal Ligament/classification , Ossification of Posterior Longitudinal Ligament/diagnostic imaging , RadiographyABSTRACT
We present an interesting case of angiosarcoma of the heart presenting as recurrent percardial effusion and cardiac tamponade.
Subject(s)
Cardiac Tamponade/etiology , Heart Neoplasms/complications , Hemangiosarcoma/complications , Fatal Outcome , Humans , Male , Middle Aged , Pericardial Effusion/etiology , RecurrenceABSTRACT
OBJECTIVE: We report our experience with use of plasmapheresis (PP) as an adjunct therapy in severe progressive neuropsychiatric systemic lupus erythematosus (NPSLE). METHOD: Three patients of NPSLE (including 2 with status epilepticus) who were progressively worsening on steroids or combination of pulse cyclophosphamide (CPM) and steroids were treated with PP followed by synchronized CPM. Pre and post treatment SLE Disease Activity Index (SLEDAI) and laboratory tests were carried out. RESULTS: Significant clinical improvement with decrease in SLEDAI occurred immediately following PP. Mean SLEDAI before and after PP were 33 and 11. Mean erythrocyte sedimentation rate decreased from 121 to 31. Rebound flare of disease activity noted in two patients between 7th-10th day requiring additional immunosuppressants or steroids. CONCLUSIONS: PP used as an adjunct therapy in severe, progressive NPSLE is well tolerated and can turn the patient around. PP should be followed by synchronized pulse CPM to prevent disease flare.