ABSTRACT
Paraneoplastic neurologic degeneration (PND) manifests as a sudden or subacute neurological syndrome often linked to underlying cancer, either overt or subclinical. Within the spectrum of PND, subacute paraneoplastic cerebellar degeneration (PCD) represents a distinctive subset. While rare, prompt diagnosis holds the potential to ameliorate both neurological and oncological outcomes. Herein, we present the case of a 61-year-old patient diagnosed with subacute cerebellar degeneration, ultimately unveiling non-small cell lung carcinoma.
ABSTRACT
Most endometrial cancer recurrences are seen within 3 years of radical treatment and are associated with various prognostic factors (tumor size, stage, grading, histotype ). Late relapses are considered rare. In this report, we present a case of a patient who was treated for endometrial adenocarcinoma. She underwent total resection and received four cycles of first-line adjuvant chemoradiation therapy using a combination of platinum salts and taxane. A total of 58 months later, the patient presented with chronic cough, and hemoptysis. A computed tomography scan revealed the presence of lung nodules suggestive of metastases. Biopsies were performed, showed infiltration of the bronchial mucosa by a poorly differentiated carcinoma of an endometrial origin. Our patient received two cycles of palliative chemotherapy but was lost to follow-up and eventually died. Imaging after hemoptysis revealed disease progression. Endometrial carcinoma patients treated with radical surgery (R0) can relapse after years of free disease. Thus, recommended: closer follow-up, clinical examination, symptom-based imaging.
ABSTRACT
Cervical squamous cell carcinoma (CSCC) is a common gynecological malignancy, typically affecting women of reproductive age. Although the occurrence of late metastatic recurrence in the lung is relatively rare, we present the case of a 52-year-old woman, previously diagnosed and treated for CSCC. After 4 years of disease-free intervals, she presented with respiratory symptoms, including cough, dyspnea, and hemoptysis, with marked asthenia. A computed tomography (CT) scan of the chest revealed a lung mass. Histopathological examination of the lung biopsy confirmed the recurrence of CSCC, specifically in the lung. Immunohistochemistry further supported the origin of the tumor as cervical. The management of such cases necessitates a multidisciplinary approach, considering treatment options such as surgery and chemoradiation. Long-term follow-up and surveillance are vital for the early detection of late recurrences, as they can present several years after the initial diagnosis. This case report highlights the importance of recognizing and appropriately managing cases of late metastatic recurrence of CSCC in the lung. Further studies are needed to deepen our understanding of the underlying mechanisms, refine diagnostic approaches, and optimize treatment strategies for such rare occurrences.
ABSTRACT
Bronchial carcinoid tumors develop from the Kulchitsky cells of the bronchial epithelium, which are stem cells with neuroendocrine properties. These tumors are divided into two types: typical forms and atypical forms, the latter being much rarer, more aggressive, and having a much higher probability of recurrence and distant metastasis. We report herein a rare case of an atypical lung carcinoid tumor metastatic to the liver. The patient is a 79-year-old woman who presented with purely digestive symptoms evolving for two years, with loss of appetite and deterioration of her general condition. The radiological assessment showed a pulmonary lesion with secondary hepatic and osseous nodules. A hepatic biopsy was performed and morphological and immunohistochemical results were compatible with an atypical bronchial carcinoid tumor, metastatic to the liver and bone.
ABSTRACT
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of neuroendocrine tumor, presenting with very aggressive behavior and a poor prognosis. The diagnosis is difficult and requires histological confirmation of the neuroendocrine nature by an immunohistochemical study on a biopsy sample. We retrospectively studied a series of 14 patients from the pneumology department of the Mohammed VI University Hospital of Oujda, Morocco, over a period of five years (from April 2017 to March 2021). The average age was 63.41 years (45-80 years). All our patients were male and smokers. The clinical signs were dominated by deterioration in general condition and dyspnea. Bronchoscopy was performed in 92% of patients, with neoplastic stenosis being the main found aspect, in 35% of cases. The histological diagnosis was obtained by bronchoscopy in 50% of cases. In the remaining cases, it was carried by CT-guided transparietal biopsy in 28% of cases, pleural biopsy in 7% of cases, biopsy of a metastatic site in 7% of cases and finally thoracoscopy with pleural biopsy in the remaining 7% of cases. Therapeutically, no patient received surgical treatment and three patients were put on palliative treatment. The positive diagnosis is often late, which makes the prognosis bad and the therapeutic possibilities limited. Hence the importance of strategies for the prevention of tobacco control and early detection in population at risk.
