Identification of FKBP10 prognostic value in lung adenocarcinoma patients with surgical resection of brain metastases: A retrospective single-institution cohort study.

OBJECTIVE: To explore the expression levels and clinical value of FKBP10 in lung adenocarcinoma brain metastases. DESIGN: A retrospective single-institution cohort study. PATIENTS: The perioperative records of 71 patients with lung adenocarcinoma brain metastases who underwent surgical resection at the authors' institution between November 2012 and June 2019 were retrospectively analyzed. METHODS: The authors evaluated FKBP10 expression levels using immunohistochemistry in tissue arrays of these patients. Kaplan-Meier survival curves were constructed, and a Cox proportional hazards regression model was used to identify independent prognostic biomarkers. A public database was used to detect FKBP10 expression and its clinical value in primary lung adenocarcinoma. RESULTS: The authors found that the FKBP10 protein was selectively expressed in lung adenocarcinoma brain metastases. Survival analysis showed that FKBP10 expression (p = 0.02, HR = 2.472, 95% CI [1.156, 5.289]), target therapy (p < 0.01, HR = 0.186, 95% CI [0.073, 0.477]), and radiotherapy (p = 0.006, HR = 0.330, 95% CI [0.149, 0.731]) were independent prognostic factors for survival in lung adenocarcinoma patients with brain metastases. The authors also detected FKBP10 expression in primary lung adenocarcinoma using a public database, found that FKBP10 is also selectively expressed in primary lung adenocarcinoma, and affects the overall survival and disease-free survival of patients. LIMITATIONS: The number of enrolled patients was relatively small and patients' treatment options varied. CONCLUSIONS: A combination of surgical resection, adjuvant radiotherapy, and precise target therapy may benefit the survival of selected patients with lung adenocarcinoma brain metastases. FKBP10 is a novel biomarker for lung adenocarcinoma brain metastases, which is closely associated with survival time and may serve as a potential therapeutic target.

Abdominal core strength training and body stability in tae kwon do athletes / Treinamento de força do centro abdominal e estabilidade corporal em atletas de tae kwon do / Entrenamiento de fuerza del núcleo abdominal y estabilidad corporal en atletas de tae kwon do

ABSTRACT Introduction: Abdominal core strength is one of the main factors controlling body balance, helping to efficiently apply body kinetic energy to the movements of Tae Kwon Do martial arts. Objective: Explore the effects of abdominal core strength training on postural stability in Tae Kwon Do athletes. Methods: Forty Tae Kwon Do competitors were randomly selected and divided into experimental and control groups. The control group was subjected to the club's regular exercise program, while the experimental group added three months of stabilization exercise to the regular exercise program. The changes in the experiment on each index were analyzed statistically. Results: After 3 months of postural balance training, Tae Kwon Do athletes' center of gravity stability was improved. The results showed significant improvement in squatting, stretching, thoracic girdle flexibility, balance ball flexion, and ipsilateral hand extension (P<0.05). Conclusion: Abdominal core strength training can improve core muscle group strength in taekwondo athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: A força do centro abdominal é um dos principais fatores de controle do equilíbrio corporal, auxiliando na aplicação eficaz da energia cinética corporal aos movimentos da arte marcial de Tae Kwon Do. Objetivo: Explorar os efeitos do treinamento de força do centro abdominal na estabilidade postural dos atletas de Tae Kwon Do. Métodos: Foram selecionados aleatoriamente 40 competidores de Tae Kwon Do, divididos em grupo experimental e grupo controle. O grupo controle foi submetido ao programa de exercício regular do clube, enquanto ao grupo experimental foram adicionados três meses de exercício de estabilização ao programa de exercício regular. As alterações do experimento em cada índice foram analisadas estatisticamente. Resultados: Após 3 meses de treinamento de equilíbrio postural, a estabilidade do centro de gravidade dos atletas de Tae Kwon Do foi aprimorada. Os resultados mostraram uma melhora significativa no agachamento, alongamento, flexibilidade de cintura torácica, flexão com bola de equilíbrio e extensão ipsilateral da mão (P<0,05). Conclusão: O treinamento de força do centro abdominal pode melhorar a força do grupo muscular central dos atletas taekwondo. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: La fuerza del núcleo abdominal es uno de los principales factores de control del equilibrio corporal, ayudando en la aplicación eficiente de la energía cinética del cuerpo a los movimientos del arte marcial Tae Kwon Do. Objetivo: Explorar los efectos del entrenamiento de la fuerza del núcleo abdominal sobre la estabilidad postural en atletas de Tae Kwon Do. Métodos: Se seleccionaron aleatoriamente 40 competidores de Tae Kwon Do, divididos en grupo experimental y grupo de control. El grupo de control fue sometido al programa de ejercicio regular del club, mientras que al grupo experimental se le añadieron tres meses de ejercicios de estabilización al programa de ejercicio regular. Los cambios del experimento en cada índice se analizaron estadísticamente. Resultados: Después de 3 meses de entrenamiento de equilibrio postural, la estabilidad del centro de gravedad de los atletas de Tae Kwon Do mejoró. Los resultados mostraron una mejora significativa en las sentadillas, los estiramientos, la flexibilidad de la cintura torácica, la flexión de la pelota de equilibrio y la extensión de la mano ipsilateral (P<0,05). Conclusión: El entrenamiento de la fuerza del núcleo abdominal puede mejorar la fuerza del grupo muscular central en los atletas de taekwondo. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Identification of FKBP10 prognostic value in lung adenocarcinoma patients with surgical resection of brain metastases: A retrospective single-institution cohort study

Abstract Objective To explore the expression levels and clinical value of FKBP10 in lung adenocarcinoma brain metastases. Design A retrospective single-institution cohort study. Patients The perioperative records of 71 patients with lung adenocarcinoma brain metastases who underwent surgical resection at the authors' institution between November 2012 and June 2019 were retrospectively analyzed. Methods The authors evaluated FKBP10 expression levels using immunohistochemistry in tissue arrays of these patients. Kaplan-Meier survival curves were constructed, and a Cox proportional hazards regression model was used to identify independent prognostic biomarkers. A public database was used to detect FKBP10 expression and its clinical value in primary lung adenocarcinoma. Results The authors found that the FKBP10 protein was selectively expressed in lung adenocarcinoma brain metastases. Survival analysis showed that FKBP10 expression (p = 0.02, HR = 2.472, 95% CI [1.156, 5.289]), target therapy (p < 0.01, HR = 0.186, 95% CI [0.073, 0.477]), and radiotherapy (p = 0.006, HR = 0.330, 95% CI [0.149, 0.731]) were independent prognostic factors for survival in lung adenocarcinoma patients with brain metastases. The authors also detected FKBP10 expression in primary lung adenocarcinoma using a public database, found that FKBP10 is also selectively expressed in primary lung adenocarcinoma, and affects the overall survival and disease-free survival of patients. Limitations The number of enrolled patients was relatively small and patients' treatment options varied. Conclusions A combination of surgical resection, adjuvant radiotherapy, and precise target therapy may benefit the survival of selected patients with lung adenocarcinoma brain metastases. FKBP10 is a novel biomarker for lung adenocarcinoma brain metastases, which is closely associated with survival time and may serve as a potential therapeutic target.

The role of ethnic and rural discrimination in the relationship between income inequality and health in Guatemala.

This article seeks to understand in the ways in which income inequality can affect children's health (z-score of stunting) in Guatemala. We postulate that there are several transmission channels through which income inequality can affect health and that the children's ethnic and rural origins influence the size and direction of this effect. The methodology employed is systems of simultaneous equations (three-stage least squares and generalized method of moments). Our results highlight the importance of rural and indigenous characteristics in the relationship between income inequality and child health and indicate that the most important transmission channels are household income levels and maternal education.