ABSTRACT
BACKGROUND: EpiFibro (Brazilian Epidemiological Study of Fibromyalgia) was created to study patients with fibromyalgia (FM). Patients were included since 2011 according to the classification criteria for FM of the American College of Rheumatology of 1990 (ACR1990). OBJECTIVE: To analyze the therapeutic measures prescribed by Brazilian physicians. MATERIALS AND METHODS: Cross-sectional study of a multicenter cohort. The therapeutic measures were described using descriptive statistics. RESULTS: We analyzed 456 patients who had complete data in the registry. The mean age was 54.0 ± 11.9 years; 448 were women (98.2%). Almost all patients (98.4%) used medications, 62.7% received health education, and less than half reported practicing physical exercise; these modalities were often used in combination. Most patients who practiced exercises practiced aerobic exercise only, and a significant portion of patients combined it with flexibility exercises. The most commonly used medication was amitriptyline, followed by cyclobenzaprine, and a minority used medication specifically approved for FM, such as duloxetine and pregabalin, either alone or in combination. Combinations of two or three medications were observed, with the combination of fluoxetine and amitriptyline being the most frequent (18.8%). CONCLUSION: In this evaluation of the care of patients with FM in Brazil, it was found that the majority of patients are treated with a combination of pharmacological measures. Non-pharmacological methods are underused, with aerobic exercise being the most commonly practiced exercise type. The most commonly prescribed single drug was amitriptyline, and the most commonly prescribed combination was fluoxetine and amitriptyline. Drugs specifically approved for FM are seldom prescribed.
Subject(s)
Fibromyalgia/therapy , Pregabalin/therapeutic use , Amitriptyline/analogs & derivatives , Amitriptyline/therapeutic use , Analgesics/therapeutic use , Analgesics, Non-Narcotic/therapeutic use , Brazil , Cohort Studies , Combined Modality Therapy/methods , Combined Modality Therapy/statistics & numerical data , Cross-Sectional Studies , Drug Therapy, Combination , Duloxetine Hydrochloride/therapeutic use , Exercise , Female , Health Education/statistics & numerical data , Humans , Male , Middle Aged , Muscle Stretching Exercises , RegistriesABSTRACT
Abstract Background: EpiFibro (Brazilian Epidemiological Study of Fibromyalgia) was created to study patients with fibromyalgia (FM). Patients were included since 2011 according to the classification criteria for FM of the American College of Rheumatology of 1990 (ACR1990). Objective: To analyze the therapeutic measures prescribed by Brazilian physicians. Materials and methods: Cross-sectional study of a multicenter cohort. The therapeutic measures were described using descriptive statistics. Results: We analyzed 456 patients who had complete data in the registry. The mean age was 54.0 ± 11.9 years; 448 were women (98.2%). Almost all patients (98.4%) used medications, 62.7% received health education, and less than half reported practicing physical exercise; these modalities were often used in combination. Most patients who practiced exercises practiced aerobic exercise only, and a significant portion of patients combined it with flexibility exercises. The most commonly used medication was amitriptyline, followed by cyclobenzaprine, and a minority used medication specifically approved for FM, such as duloxetine and pregabalin, either alone or in combination. Combinations of two or three medications were observed, with the combination of fluoxetine and amitriptyline being the most frequent (18.8%). Conclusion: In this evaluation of the care of patients with FM in Brazil, it was found that the majority of patients are treated with a combination of pharmacological measures. Non-pharmacological methods are underused, with aerobic exercise being the most commonly practiced exercise type. The most commonly prescribed single drug was amitriptyline, and the most commonly prescribed combination was fluoxetine and amitriptyline. Drugs specifically approved for FM are seldom prescribed.(AU)
Subject(s)
Humans , Fibromyalgia/drug therapy , Fibromyalgia/therapy , Records , Fluoxetine/therapeutic use , Cross-Sectional Studies , Cohort Studies , Physical Therapy Modalities , Drug Combinations , Pregabalin/therapeutic use , Duloxetine Hydrochloride/therapeutic use , Amitriptyline/therapeutic useABSTRACT
OBJECTIVE: To assess knowledge on fibromyalgia in a sample of patients, their families, and professionals interested on the theme from some Brazilian states. METHODS: Analysis of the results of an electronic fibromyalgia knowledge questionnaire completed by 362 adults who had access to the the support group for fibromyalgia site (www.unifesp.br/grupos/fibromialgia). The answers were grouped according to age, sex, years of schooling, and type of interest in the condition. RESULTS: 92% of the responders were women and 62% had higher educational level. The worst results were observed in the "joint protection and energy conservation" domain, followed by the "medication in fibromyalgia" domain. The best results were recorded in the "exercises in fibromyalgia" domain. The answers differed significantly between sexes, and women achieved a higher percentage of correct answers. The female sex accounted for a statistically superior result in five statistical analyses (four questions and one domain). CONCLUSIONS: The study suggests the need for a strategic planning for an educational approach to fibromyalgia in Brazil.
Subject(s)
Fibromyalgia , Health Knowledge, Attitudes, Practice , Internet , Adult , Female , Humans , Male , Surveys and QuestionnairesABSTRACT
OBJETIVO: Analisar o nível de conhecimento sobre fibromialgia em uma amostra incluindo pacientes, familiares e profissionais de vários estados do Brasil. MÉTODOS: Análise dos resultados de 362 adultos que acessaram o site do Grupo de Apoio à Fibromialgia (www.unifesp.br/grupos/fibromialgia) e responderam a um questionário eletrônico de conhecimento sobre a síndrome. As respostas foram avaliadas em relação a idade, sexo, nível de escolaridade e tipo de interesse no Grupo. RESULTADOS: 92 por cento eram mulheres e 62 por cento haviam completado o ensino superior. O pior resultado foi no domínio "proteção articular e conservação de energia", seguido pelo domínio "conhecimento sobre medicação". O melhor resultado ocorreu no domínio "exercícios para fibromialgia". Houve diferença significativa entre os gêneros, sendo as mulheres responsáveis por um porcentual maior de acertos. O gênero feminino foi responsável por um resultado estatisticamente superior em cinco análises estatísticas (quatro perguntas e um domínio). CONCLUSÕES: O estudo sugere a necessidade de um planejamento estratégico para ações educativas sobre fibromialgia no Brasil.
OBJECTIVE: To assess knowledge on fibromyalgia in a sample of patients, their families, and professionals interested on the theme from some Brazilian states. METHODS: Analysis of the results of an electronic fibromyalgia knowledge questionnaire completed by 362 adults who had access to the the support group for fibromyalgia site (www.unifesp.br/grupos/fibromialgia). The answers were grouped according to age, sex, years of schooling, and type of interest in the condition. RESULTS: 92 percent of the responders were women and 62 percent had higher educational level. The worst results were observed in the "joint protection and energy conservation" domain, followed by the "medication in fibromyalgia" domain. The best results were recorded in the "exercises in fibromyalgia" domain. The answers differed significantly between sexes, and women achieved a higher percentage of correct answers. The female sex accounted for a statistically superior result in five statistical analyses (four questions and one domain). CONCLUSIONS: The study suggests the need for a strategic planning for an educational approach to fibromyalgia in Brazil.
Subject(s)
Adult , Female , Humans , Male , Fibromyalgia , Health Knowledge, Attitudes, Practice , Internet , Surveys and QuestionnairesABSTRACT
The primary aim of this study was to assess the quality of life (Qol) in men with fibromyalgia (FM) as compared to the Qol of depressive patients, using the SF-36 questionnaire. The secondary objectives were as follows: to describe demographic and clinical characteristics of male patients with FM; to evaluate basal levels of dehydroepiandrosterone sulfate (DHEAS) and total testosterone in both groups; and to investigate the relationship among pain, tender points, anxiety, and depression in these patients. Fifty men with FM and 20 depressed males, matched by age and body mass index entered the study. All participants answered the SF-36, the Beck Depression Inventory and the State-Trait Anxiety Inventory questionnaire. Radioimmunoassay was used to determine serum concentration of DHEAS and total testosterone. Patients and controls had similar demographic characteristics. The scores were significantly lower in all domains of the SF-36 in patients with FM as compared with the depressive controls. No significant differences were observed among patient and control in the mean concentration of either DHEAS or total testosterone. Male patients with FM experience worse Qol than depressive men. Depression was influential on mental health, whereas FM impacted on both physical and mental health.
Subject(s)
Depression/physiopathology , Fibromyalgia/physiopathology , Activities of Daily Living , Adolescent , Adult , Aged , Anxiety , Brazil , Dehydroepiandrosterone/blood , Demography , Depression/blood , Depression/psychology , Fibromyalgia/blood , Fibromyalgia/psychology , Humans , Male , Middle Aged , Pain/physiopathology , Pain Measurement , Quality of Life , Sickness Impact Profile , Testosterone/blood , Young AdultABSTRACT
Estudou-se a sobrevida de camundongos inoculados com tumor de Ehrlich na vigência de tratamento estrogênico, e concomitantemente fêz-se uma avaliaçäo da atividade imunológica em um grupo paralelo. Concluiu-se que os estrógenos aceleram a mortalidade de camundongos machos portadores de tumor de Ehrlich e näo provocavam alteraçöes no número de macrófagos e atividade fagocitária em resposta à inflamaçäo. Os camundongos que receberam tumor de Ehrlich também näo apresentaram diferenças em relaçäo ao grupo de camundongos normais