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1.
J R Soc Interface ; 13(121)2016 08.
Article in English | MEDLINE | ID: mdl-27534701

ABSTRACT

A simple mechanical model of the skateboard-skater system is analysed, in which the effect of human control is considered by means of a linear proportional-derivative (PD) controller with delay. The equations of motion of this non-holonomic system are neutral delay-differential equations. A linear stability analysis of the rectilinear motion is carried out analytically. It is shown how to vary the control gains with respect to the speed of the skateboard to stabilize the uniform motion. The critical reflex delay of the skater is determined as the function of the speed. Based on this analysis, we present an explanation for the linear instability of the skateboard-skater system at high speed. Moreover, the advantages of standing ahead of the centre of the board are demonstrated from the viewpoint of reflex delay and control gain sensitivity.


Subject(s)
Models, Neurological , Reflex/physiology , Skating/physiology , Humans
2.
PLoS Comput Biol ; 11(12): e1004609, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26683341

ABSTRACT

In Parkinson's disease, an increase in beta oscillations within the basal ganglia nuclei has been shown to be associated with difficulty in movement initiation. An important role in the generation of these oscillations is thought to be played by the motor cortex and by a network composed of the subthalamic nucleus (STN) and the external segment of globus pallidus (GPe). Several alternative models have been proposed to describe the mechanisms for generation of the Parkinsonian beta oscillations. However, a recent experimental study of Tachibana and colleagues yielded results which are challenging for all published computational models of beta generation. That study investigated how the presence of beta oscillations in a primate model of Parkinson's disease is affected by blocking different connections of the STN-GPe circuit. Due to a large number of experimental conditions, the study provides strong constraints that any mechanistic model of beta generation should satisfy. In this paper we present two models consistent with the data of Tachibana et al. The first model assumes that Parkinsonian beta oscillation are generated in the cortex and the STN-GPe circuits resonates at this frequency. The second model additionally assumes that the feedback from STN-GPe circuit to cortex is important for maintaining the oscillations in the network. Predictions are made about experimental evidence that is required to differentiate between the two models, both of which are able to reproduce firing rates, oscillation frequency and effects of lesions carried out by Tachibana and colleagues. Furthermore, an analysis of the models reveals how the amplitude and frequency of the generated oscillations depend on parameters.


Subject(s)
Beta Rhythm , Biological Clocks , Brain/physiopathology , Models, Neurological , Nerve Net/physiopathology , Parkinson Disease/physiopathology , Action Potentials , Computer Simulation , Humans , Oscillometry/methods
3.
Eur J Neurosci ; 36(2): 2229-39, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22805067

ABSTRACT

A key pathology in the development of Parkinson's disease is the occurrence of persistent beta oscillations, which are correlated with difficulty in movement initiation. We investigated the network model composed of the subthalamic nucleus (STN) and globus pallidus (GP) developed by A. Nevado Holgado et al. [(2010) Journal of Neuroscience, 30, 12340-12352], who identified the conditions under which this circuit could generate beta oscillations. Our work extended their analysis by deriving improved analytic stability conditions for realistic values of the synaptic transmission delay between STN and GP neurons. The improved conditions were significantly closer to the results of simulations for the range of synaptic transmission delays measured experimentally. Furthermore, our analysis explained how changes in cortical and striatal input to the STN-GP network influenced oscillations generated by the circuit. As we have identified when a system of mutually connected populations of excitatory and inhibitory neurons can generate oscillations, our results may also find applications in the study of neural oscillations produced by assemblies of excitatory and inhibitory neurons in other brain regions.


Subject(s)
Beta Rhythm/physiology , Globus Pallidus/physiology , Models, Neurological , Subthalamic Nucleus/physiology , GABAergic Neurons/physiology , Humans , Nerve Net/physiology , Parkinson Disease/physiopathology , Synaptic Transmission/physiology
4.
Phys Rev E Stat Nonlin Soft Matter Phys ; 78(4 Pt 1): 041706, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18999444

ABSTRACT

In planar nematic electrohydrodynamic convection (EHC), a microscopic liquid crystal cell is driven by a homogeneous ac electric field, which, if strong enough, causes the fluid to destabilize into a regular pattern-forming state. We consider asymmetric electric fields E(t)=E(t+T) not equal-E(t+T2) , which leads to the possibility of three different types of instabilities at onset: conductive, dielectric, and subharmonic. The first two are already well known as they are easily produced when the system is driven by symmetric electric fields; the third can only occur when the electric field symmetry is broken. We present theoretical results on EHC using linear stability analysis and Floquet theory. We consider rigid and free boundary conditions, extending the model to two Fourier modes in the vertical plane, the inclusion of flexoelectricity, and using standard (nematic electric conductivity sigma_{a}>0 and dielectric anisotorpy _{a}<0 ) and nonstandard (sigma_{a}<0) material parameters. We make full use of a three-dimensional linear model where two mutually perpendicular planar wave numbers q and p can be varied. Our results show that there is a qualitative difference between the boundary conditions used, which is also dependent on how many vertical Fourier modes were used in the model. We have obtained threshold values favoring oblique rolls in subharmonic and dielectric regimes in parameter space. For the nonstandard EHC parameter values, both conduction and subharmonic regimes disappear and only the dielectric threshold exists.

5.
Chaos ; 14(4): 1069-77, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15568921

ABSTRACT

In the case of low immersion high-speed milling, the ratio of time spent cutting to not cutting can be considered as a small parameter. In this case the classical regenerative vibration model of machine tool vibrations reduces to a simplified discrete mathematical model. The corresponding stability charts contain stability boundaries related to period doubling and Neimark-Sacker bifurcations. The subcriticality of both types of bifurcations is proved in this paper. Further, global period-2 orbits are found and analyzed. In connection with these orbits, the existence of chaotic motion is demonstrated for realistic high-speed milling parameters.

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