ABSTRACT
Objective: To explore the influence factors of contrast agent venous intravasation in the process of transvaginal ultrasound four-dimensional hysterosalpingo-contrast sonography (TVS 4D-HyCoSy). Methods: Data of 1 328 infertile patients who underwent TVS 4D-HyCoSy were analyzed retrospectively. Univariate analysis and Logistic regression analysis were used to observe the impact factors of contrast agent venous intravasation. Results: Among 1 328 infertile patients, contrast agent venous intravasation was observed in 293 (293/1 328, 22.06%) patients. Univariate analysis results showed that there were significant differences of patient's age, infertility type, dysmenorrhea history, injection resistance, contrast agent reflux, pain degree and tubal patency between patients with or without contrast agent venous intravasation (all P<0.05). Logistic regression analysis showed that age, infertile type, contrast agent reflux and fallopian tube flatness were independent impact factors of contrast agent venous intravasation (all P<0.05). Conclusion: Contrast agent venous intravasation correlate with patient's age, infertility type, contrast agent reflux and tubal patency during TVS 4D-HyCoSy.
ABSTRACT
OBJECTIVE: Our objective was to explore whether the pregnancy rate (PR) was higher than usual after hysterosalpingo-contrast sonography (HyCoSy). METHODS: We conducted a prospective observational study of 1,008 infertility patients, all of whom were examined by HyCoSy. The expected time for spontaneous pregnancy was at least 180 days after the HyCoSy exams. There were three types of HyCoSy results: type I, defined as both fallopian tubes patent; type II, defined as one fallopian tube patent with obstruction in the other; and type III, defined as both fallopian tubes obstructed. During the HyCoSy examinations, we recorded the mobility of the ovaries, injective resistance, and contrast agent venous intravasation. Before the examinations, we recorded each patient's medical history, including maternal age, infertility type, median duration of menstrual cycle, dysmenorrhea, and parity number. RESULTS: The PR was 19.44% within 180 days after HyCoSy and it was significantly higher in the first 30 days (6.35%) (P <.01). The PR of type I was highest, with a rate of 32.01%, followed by the PR of type II (25.51%) and type III (15.04%) (P <.01). Univariate analysis showed that younger age, patency of both fallopian tubes, good ovarian mobility, and absence of injective resistance were positively related to the initiation of pregnancy (P <.01). Infertility type, median duration of menstrual cycle, dysmenorrhea, parity number, contrast agent venous intravasation, and identity of the sonographer were unrelated to pregnancy (P >.05). However, multivariate analysis showed that patency of both fallopian tubes and the absence of injective resistance were independently associated with pregnancy. CONCLUSION: Some infertility patients conceived successfully and naturally not long after HyCoSy, most often in the first month after the examination. Multivariate analysis showed that patency of both fallopian tubes and the absence of injective resistance were independently factors associated with the ability to conceive after HyCoSy examination.