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1.
Eur J Orthop Surg Traumatol ; 33(1): 135-142, 2023 Jan.
Article in English | MEDLINE | ID: mdl-34820742

ABSTRACT

PURPOSE: Our objectives were (1) to compare the recurrence, metastases, and complication rates of patients with Enneking stage 3 GCTB who underwent extended curettage vs wide resection and (2) examine the factors which might influence surgical options for each patient. METHODS: We retrospectively reviewed the records of patients with Enneking stage 3 GCTB from January 2006-December 2015. Extended curettage was performed in patients in whom there was a moderate expansile lesion, minimal/no articular cartilage damage, and less than 50% of cortical deformation compared to its circumference from a CT scan/MRI. The percentages of cortical deformation were collected. Surgical complications, recurrence, and metastatic rates were analyzed. RESULTS: There were 28 extended curettage and 41 wide resections. The mean percentages of cortical deformation compared to circumference were 52.6% (range, 23.9-81.9%) and 91.6% (range, 52.1-100%)(P < 0.01) for the curettage and wide resection groups, respectively. There were three recurrences, 2/28 (7.1%) from the curettage group and 1/41 (2.4%) from the resection group (P = 0.56). There were no cases of pulmonary metastasis. There were two complications in the curettage group and five complications in the resection group. CONCLUSION: Both extended curettage and wide resection are useful methods to treat Enneking stage 3 GCTB. Extended curettage with proper technique is a viable option showing no difference in local recurrence rate and potentially fewer complications. Preference to do extended curettage in patients in whom when the articular cartilage has minimal or no destruction, a moderate expansile lesion and the cortical deformation is less than 50% of the circumference.


Subject(s)
Bone Neoplasms , Cartilage, Articular , Giant Cell Tumor of Bone , Humans , Giant Cell Tumor of Bone/diagnostic imaging , Giant Cell Tumor of Bone/surgery , Bone Neoplasms/pathology , Retrospective Studies , Curettage/methods , Neoplasm Recurrence, Local/pathology
3.
Clin Orthop Relat Res ; 480(1): 109-120, 2022 01 01.
Article in English | MEDLINE | ID: mdl-34406138

ABSTRACT

BACKGROUND: Pasteurized bone autograft is a recycling biological reconstruction method for limb-sparing surgery when an allograft or other reconstruction technique is unavailable. Since the application of a local bisphosphonate to morselized allografts can reduce graft resorption and enhance bone formation without systemic complications, adding the local bisphosphonate to pasteurized bone autografts should reduce the graft resorption and improve the graft incorporation to host bone. However, no study that we know of has described the outcomes of local bisphosphonate application to massive allografts or pasteurized bone autografts. Thus, this study compared the outcomes of pasteurized bone autografts with and without local zoledronate. QUESTIONS/PURPOSES: (1) What is the survival of pasteurized bone autografts and what complications lead to graft removal? (2) Does treatment of pasteurized bone autografts with zoledronate alter the survival of pasteurized bone autografts compared with grafts without treatment? (3) Does the local application of zoledronate reduce the proportion of patients with fractures because of metaphyseal graft resorption? (4) Does local application of zoledronate improve union at the graft-host bone junction compared with untreated grafts? METHODS: Between July 2011 and December 2019, we performed 538 musculoskeletal bone tumor resections. Of these, 101 patients underwent reconstruction with pasteurized bone autografts. Other reconstructions included tumor prostheses (150 patients), allografts (70 patients), reconstruction using a bone cement-plate construct (62 patients), and resection only (155 patients). We generally used pasteurized bone autograft when tumors showed an osteoblastic pattern, had less than one-third cortical destruction, and less than half of metaphyseal bone destruction. Six percent (6 of 101) were lost to follow-up, 6% (6 of 101) had incomplete clinical data, and 16% (16 of 101) had a follow-up period less than 2 years without an event, leaving 73 patients for evaluation. The median (interquartile range) age of the patients was 18 years (15 to 26). Ninety-seven percent (71 of 73) had a diagnosis of bone sarcoma. The median follow-up time was 46 months (33 to 75). From 2011 to 2014, 21 pasteurized bone autografts were prepared without local zoledronate, and from 2014 to 2019, 52 pasteurized bone autografts were prepared with local zoledronate because we thought it might improve union and reduce resorption of the graft. From our tumor registry database, we obtained age, sex, use of chemotherapy, graft length and location, pasteurized bone graft type, fixation methods, the use of local zoledronate, osteotomy gap, complications, proportion of grafts that united by 2 years, and local recurrences. Curves for graft survival were determined using the Kaplan-Meier method with the endpoint of autograft removal and metaphyseal fracture from graft resorption. The probabilities of graft removal were estimated by cumulative incidences using the competing risk analysis, where death was considered as the competing event. Intergroup differences in survival and multivariable analyses were performed using the log-rank test and a Cox regression analysis. A logistic regression model was used to evaluate the association between graft-host osseous union by 2 years and other baseline factors. Union was defined when a callus was seen to bridge the osteotomy line for at least three cortices in both the AP and mediolateral planes. RESULTS: The 5-year survival rate of all 73 pasteurized grafts was 85% (95% confidence interval 74% to 92%). With the numbers available, we found no difference in the 5-year survival rates between grafts with and without local zoledronate (90% [95% CI 78% to 96%] versus 74% [95% CI 48% to 89%]; p = 0.30). Eleven percent (8 of 73) of patients had metaphyseal fractures because of graft resorption, primarily associated with osteoarticular grafts (5-year fracture-free survival 56% [95% CI 20 to 80]) rather than pasteurized graft-prosthesis composites (94% [95% CI 78% to 98%]) and intercalary grafts (91% [95% CI 50 to 99]; p = 0.001); there was no association with the use of local zoledronate (13%; 7 of 52) compared with those without local zoledronate (5%; 1 of 21) (odds ratio 3.1 [95% CI 0.4 to 27]; p = 0.43). Of the 84 graft-host bone junctions, 85% (71) of the grafts unified within 2 years, 7% (6) unified after 2 years, and 8% (7) of grafts showed nonunion. Union within 2 years was associated with fixation using plate compared with those with stem and with both stem and plate (odds ratio 6.6 [95% CI 1.4 to 31]; p = 0.02) and grafts treated with local zoledronate compared with those without treatment (OR 5.9 [95% CI 1.3 to 28]; p = 0.02). CONCLUSION: The application of local zoledronate to pasteurized bone autografts for limb-sparing surgery improved the likelihood of graft union compared with untreated grafts, especially when the osteotomy junctions were fixed using plate osteosynthesis, but it did not appear to alter the proportion of patients who experience metaphyseal fracture of the grafts because of graft resorption. Although this is a small study, it suggests that the treatment of pasteurized bone autografts and perhaps bone allografts should be studied further to determine whether bisphosphonates or other adjuncts can improve the union time and return to function in patients undergoing bone tumor resections using these reconstruction types. LEVEL OF EVIDENCE: Level III, therapeutic study.


Subject(s)
Autografts/drug effects , Bone Neoplasms/surgery , Bone Transplantation/methods , Graft Survival/drug effects , Pasteurization/methods , Zoledronic Acid/administration & dosage , Adolescent , Adult , Bone Density Conservation Agents/administration & dosage , Female , Humans , Limb Salvage , Male , Retrospective Studies , Young Adult
4.
J Imaging ; 8(1)2021 Dec 27.
Article in English | MEDLINE | ID: mdl-35049843

ABSTRACT

Osteosarcoma is a rare bone cancer which is more common in children than in adults and has a high chance of metastasizing to the patient's lungs. Due to initiated cases, it is difficult to diagnose and hard to detect the nodule in a lung at the early state. Convolutional Neural Networks (CNNs) are effectively applied for early state detection by considering CT-scanned images. Transferring patients from small hospitals to the cancer specialized hospital, Lerdsin Hospital, poses difficulties in information sharing because of the privacy and safety regulations. CD-ROM media was allowed for transferring patients' data to Lerdsin Hospital. Digital Imaging and Communications in Medicine (DICOM) files cannot be stored on a CD-ROM. DICOM must be converted into other common image formats, such as BMP, JPG and PNG formats. Quality of images can affect the accuracy of the CNN models. In this research, the effect of different image formats is studied and experimented. Three popular medical CNN models, VGG-16, ResNet-50 and MobileNet-V2, are considered and used for osteosarcoma detection. The positive and negative class images are corrected from Lerdsin Hospital, and 80% of all images are used as a training dataset, while the rest are used to validate the trained models. Limited training images are simulated by reducing images in the training dataset. Each model is trained and validated by three different image formats, resulting in 54 testing cases. F1-Score and accuracy are calculated and compared for the models' performance. VGG-16 is the most robust of all the formats. PNG format is the most preferred image format, followed by BMP and JPG formats, respectively.

5.
Clin Orthop Relat Res ; 478(11): 2573-2581, 2020 11.
Article in English | MEDLINE | ID: mdl-32469487

ABSTRACT

BACKGROUND: Aseptic loosening is one of the most common causes of revision of distal femoral endoprostheses and is considered a mid- to long-term complication. There are not many reports of 10-year survivorship free from aseptic loosening and all-cause survivorship in cemented stems. To our knowledge, there are no reports on radiographic features that are associated with aseptic loosening of these implants. QUESTIONS/PURPOSES: (1) What is the 5- and 10-year survivorship free from aseptic loosening in patients undergoing reconstruction with a cemented distal femoral endoprosthesis after a tumor resection? (2) What is the all-cause 5- and 10-year survivorship at in these patients? (3) What radiographic features are associated with aseptic loosening at long-term follow-up? METHODS: We performed a multicenter retrospective study reviewing aseptic loosening in cemented prostheses to determine radiographic features associated with long-term implant survivorship. Patients who underwent a cemented distal femoral reconstruction with a modular endoprosthesis after resection of a musculoskeletal tumor between 1997 and 2017 were reviewed. A total of 246 patients were identified from five institutions and met initial inclusion criteria. Of those, 21% (51) were lost to follow-up before 2 years, leaving 195 patients available for us to evaluate and analyze the survivorship and radiologic features associated with long-term implant survival. The mean (range) follow-up was 78 months (22 to 257). At the time of this analysis, 69% (135 of 195) of the patients were alive. Osteosarcoma was the most common diagnosis in 43% of patients (83 of 195), followed by metastatic carcinoma 13% (25 of 195). Fifty-six percent (110 of 195) of patients received chemotherapy; 15% (30 of 195) had radiation therapy. Aseptic loosening was diagnosed radiographically and was defined as a circumferential radiolucent line on all views, or subsidence around the stem in the absence of infection. We present 5- and 10-year Kaplan-Meier survivorship free from aseptic loosening, 5- and 10-year all-cause survivorship, and a qualitative assessment of radiographic features potentially associated with aseptic loosening (including the junctional radiolucent area, and cortical expansion remodeling). The junctional radiolucent area was defined as a radiolucent area of the bone starting at the bone-endoprosthesis junction to the tip of the femoral stem, and cortical expansion remodeling was defined as an increased cortical thickness at the stem tip. Although we wished to statistically analyze radiographic factors potentially associated with aseptic loosening, we did not have enough clinical material to do so (only nine patients developed loosening). Instead, we will report a few preliminary qualitative observations, which necessarily are preliminary, and which will need to be confirmed or refuted by future studies. We urge caution in interpreting these findings because of the very small numbers involved. RESULTS: Kaplan-Meier survivorship free from aseptic loosening of the femoral component at 5 and 10 years were 95% (95% CI 89 to 98) and 93% (95% CI 86 to 97), respectively. Kaplan-Meier survivorship free from revision for any cause at 5 and 10 years were 74% (95% CI 65 to 79) and 64% (95% CI 49 to 70), respectively. Although the numbers were too small to analyze statistically, all patients with aseptic loosening had a junctional radiolucent area more than 20% of the total length of the stem without cortical expansion remodeling at the stem tip. No aseptic loosening was observed if there was cortical ex remodeling, a junctional radiolucent area less than 20%, or curved stems that were 13 mm or greater in diameter. The numbers of patients with aseptic loosening in this series were too small to analyze statistically. CONCLUSIONS: Cemented distal femoral endoprostheses have a relatively low rate of aseptic loosening and acceptable projected first-decade survivorship. The presence of a radiolucent area more than 20% without cortical expansion remodeling at the stem tip may lead to aseptic loosening in patients with these implants. Close radiographic surveillance and revision surgery may be considered for progressive lucencies and clinical symptoms of pain. If revision is contemplated, we recommend using larger diameter curved cemented stems. These are preliminary and provisional observations based on a low number of patients with aseptic loosening; future studies with greater numbers of patients are needed to validate or refute these findings. LEVEL OF EVIDENCE: Level III, therapeutic study.


Subject(s)
Bone Cements , Femoral Neoplasms/diagnostic imaging , Femoral Neoplasms/surgery , Joint Prosthesis , Plastic Surgery Procedures , Prosthesis Failure , Reoperation , Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Retrospective Studies , Young Adult
6.
Clin Orthop Relat Res ; 475(3): 643-655, 2017 Mar.
Article in English | MEDLINE | ID: mdl-26911974

ABSTRACT

BACKGROUND: After total sacrectomy, many types of spinopelvic reconstruction have been described with good functional results. However, complications associated with reconstruction are not uncommon and usually result in further surgical interventions. Moreover, less is known about patient function after total sacrectomy without spinopelvic reconstruction, which may be indicated when malignant or aggressive benign bone and soft tissue tumors involved the entire sacrum. QUESTIONS/PURPOSES: (1) What is the functional outcome and ambulatory status of patients after total sacrectomy without spinopelvic reconstruction? (2) What is the walking ability and ambulatory status of patients when categorized by the location of the iliosacral resection relative to the sacroiliac joint? (3) What complications and reoperations occur after this procedure? METHODS: Between 2008 and 2014, we performed 16 total sacrectomies without spinopelvic reconstructions for nonmetastatic oncologic indications. All surviving patients had followup of at least 12 months, although two were lost to followup after that point (mean, 43 months; range, 12-66 months, among surviving patients). During this time period, we performed total sacrectomy without reconstruction for all patients with primary bone and soft tissue tumors (benign and malignant) involving the entire sacrum with no initial metastasis. The level of resection was the L5-S1 disc in 14 patients and L4-L5 disc in two patients. We classified the resection into two types based on the location of the iliosacral resection. Type I resections went medial to or through or lateral but close to the sacroiliac joint. Type II resections were far lateral (more than 3 cm from the posterior iliac spine) to the sacroiliac joint. Musculoskeletal Tumor Society (MSTS) scores, physical function assessments, and complications were gleaned from chart review performed by the treating surgeons (PK, BS). Video documentation of patients walking was obtained at followup in eight patients. RESULTS: The mean overall MSTS scores was 17 (range, 5-27). Thirteen patients were able to walk, five without walking aids, two with a cane and sometimes without a walking aid, three with a cane, and three with a walker. Thirteen of 14 patients who had bilateral Type I resections or a Type I resection on one side and Type II on the contralateral side were able to walk, five without a walking aid, and had a mean MSTS score of 19 (range, 13-27). Two patients with bilateral Type II resection were only able to sit. Complications included wound dehiscences in 13 patients (which were treated with reoperation for drainage), sciatic nerve injury in seven patients, a torn ureter in one patient, and a rectal tear in one patient. CONCLUSIONS: Without spinopelvic reconstruction, most patients in this series who underwent total sacrectomy were able to walk. Good MSTS scores could be expected in patients with bilateral Type I resections and patients with a Type I on one side and a Type II on the contralateral side. Total sacrectomy without spinopelvic reconstruction should be considered as a useful alternative to reconstructive surgery in patients who undergo Type I iliosacral resection on one or both sides. LEVEL OF EVIDENCE: Level IV, therapeutic study.


Subject(s)
Neurosurgical Procedures , Osteotomy , Sacrum/surgery , Soft Tissue Neoplasms/surgery , Spinal Neoplasms/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Biomechanical Phenomena , Dependent Ambulation , Disability Evaluation , Female , Humans , Male , Medical Records , Middle Aged , Mobility Limitation , Neurosurgical Procedures/adverse effects , Osteotomy/adverse effects , Postoperative Complications/etiology , Postoperative Complications/physiopathology , Postoperative Complications/surgery , Plastic Surgery Procedures , Recovery of Function , Reoperation , Retrospective Studies , Sacrum/diagnostic imaging , Sacrum/physiopathology , Soft Tissue Neoplasms/diagnostic imaging , Soft Tissue Neoplasms/physiopathology , Spinal Neoplasms/diagnostic imaging , Spinal Neoplasms/physiopathology , Time Factors , Tomography, X-Ray Computed , Treatment Outcome , Walking , Young Adult
7.
World J Surg Oncol ; 13: 4, 2015 Jan 12.
Article in English | MEDLINE | ID: mdl-25578802

ABSTRACT

BACKGROUND: Metastatic bone disease involving the acetabulum is a debilitating condition causing significant pain and disability for patients. Many methods of reconstruction have been described for treating Harrington class II and III lesions with different results and complications. Our objectives were to report functional results, implant survival and complications following reconstruction for Harrington class II and III periacetabular metastases by using anti-protusio cages, screws and joint replacement. METHODS: We reviewed 22 patients undergoing acetabular reconstruction for metastatic disease. There were 5 Harrington class II and 17 class III lesions. Intralesional curettage, multiple screws and cemented total hip replacement were performed in all patients. Anti-protusio cages were used in 19 hips. No Steinmann pins were used. Sixteen patients died at a median survival time of 12 months (range, 4 to 28 months) after surgery. Six patients were alive at last follow-up at a median of 8 months (range, 3 to 15 months). RESULTS: Postoperatively, the average ECOG score was improved from 3.1 to 1.7 and Visual Analog Scale was improved from 8.4 to 2.2. One patient developed hip dislocation and one patient developed superficial infection. The mean Musculoskeletal Tumor Society (MSTS) functional score was 70 (range, 27 to 87). There was no prosthetic loosening or revision. Twenty patients were able to walk. Eight patients became community ambulators, twelve became household ambulators and two were bed-bound. CONCLUSIONS: Good functional outcome and better ambulation could be expected following class II and III periacetabular reconstruction using anti-protusio cages, screws and cemented hip replacement. Few complications were noted and manageable. Although most of these patients with metastatic disease had limited life expectancies, their quality of life would be improved with appropriate patient selection and surgical reconstruction.


Subject(s)
Acetabulum/surgery , Arthroplasty, Replacement, Hip/methods , Bone Neoplasms/surgery , Hip Joint/physiopathology , Hip Prosthesis , Postoperative Complications , Acetabulum/diagnostic imaging , Acetabulum/physiopathology , Adult , Aged , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/secondary , Bone Screws , Female , Humans , Male , Middle Aged , Radiography , Plastic Surgery Procedures , Retrospective Studies , Walking
8.
J Orthop Surg (Hong Kong) ; 22(2): 257-62, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25163969

ABSTRACT

Oncogenic osteomalacia is caused by a small mesenchymal tumour characterised by phosphaturia, hypophosphatemia, decreased serum vitamin D3 level, and osteomalacia. Phosphaturic mesenchymal tumour of the mixed connective tissue type (PMTMCT) is the commonest subtype and usually involves a single site. We report a case of PMTMCT involving the left proximal and shaft of the tibia in a 42-year-old man.


Subject(s)
Bone Neoplasms/diagnosis , Neoplasms, Connective Tissue/diagnosis , Tibia , Adult , Bone Neoplasms/etiology , Bone Neoplasms/therapy , Humans , Male , Neoplasms, Connective Tissue/etiology , Neoplasms, Connective Tissue/therapy , Osteomalacia , Paraneoplastic Syndromes
9.
J Orthop Surg (Hong Kong) ; 22(3): 409-14, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25550028

ABSTRACT

We report on a 58-year-old woman who underwent total sacrectomy and spinopelvic reconstruction for a low-grade malignant peripheral nerve sheath tumour involving the sacrum. One week later, she developed deep wound infection, and the entire spinopelvic reconstruction was removed. At the 36-month followup, the patient had no pain and was able to walk with a walking frame. There was no sign of recurrence or metastasis.


Subject(s)
Nerve Sheath Neoplasms/surgery , Plastic Surgery Procedures/methods , Sacrum/surgery , Spinal Neoplasms/surgery , Debridement , Device Removal , Female , Humans , Humerus/transplantation , Lumbar Vertebrae/surgery , Middle Aged , Nerve Sheath Neoplasms/diagnosis , Pelvic Bones/surgery , Plastic Surgery Procedures/adverse effects , Spinal Neoplasms/diagnosis , Surgical Wound Infection/etiology , Transplantation, Homologous
10.
J Orthop Surg (Hong Kong) ; 21(2): 204-8, 2013 Aug.
Article in English | MEDLINE | ID: mdl-24014785

ABSTRACT

PURPOSE. To compare computed tomography (CT)- guided core needle biopsy (CNB) with incisional biopsy in diagnosing musculoskeletal lesions. METHODS. 62 men and 50 women aged 12 to 83 (mean, 45) years who underwent a CT-guided CNB were compared with 31 men and 33 women aged 9 to 81 (mean, 53) years who underwent an incisional biopsy. All specimens had final pathology report to compare with. Comparisons were made in terms of (1) diagnostic rate, (2) accuracy in distinguishing benign from malignant lesions, (3) accuracy in distinguishing low- from high-grade sarcomas, (4) accuracy for histological diagnosis, and (5) complication and repeated biopsy rates. RESULTS. The diagnostic rate of CT-guided CNB and incisional biopsy was not significantly different (92.9% vs. 96.9%, p=0.33), nor were the accuracy in distinguishing benign from malignant lesions (100% vs. 98.4%, p=0.37), the accuracy in distinguishing low- from high-grade sarcomas (100% vs. 100%, p=1.00), the accuracy for specific diagnosis (75.9% vs. 85.2%, p=0.17), the repeated biopsy rate (6.3% vs. 4.7%, p=0.75), and the complication rate (0.9% vs. 4.7%, p=0.14). The accuracy for specific diagnosis was higher for bone than soft-tissue lesions for both CT-guided CNB (87.0% vs. 59.5%, p=0.002) and incisional biopsy (87.0% vs. 77.3%, p=0.43). The accuracy of CT-guided CNB for specific diagnosis of benign soft-tissue tumours as well as infection and inflammation was relatively low. CONCLUSION. CT-guided CNB is safe, easy to perform, efficient, and less invasive, and should be considered as a first-line biopsy for musculoskeletal lesions.


Subject(s)
Bone Neoplasms/pathology , Musculoskeletal Diseases/pathology , Sarcoma/pathology , Soft Tissue Neoplasms/pathology , Adolescent , Biopsy , Biopsy, Large-Core Needle , Child , Female , Humans , Male , Tomography, X-Ray Computed , Young Adult
11.
J Foot Ankle Surg ; 50(5): 598-602, 2011.
Article in English | MEDLINE | ID: mdl-21616685

ABSTRACT

Giant cell tumor of the distal phalanx of a toe is rather unusual. We report an unusual case of giant cell tumor arising at the distal phalanx of the left biphalangeal fifth toe in a 13-year-old boy. This was treated successfully with curettage and packing with bone substitution.


Subject(s)
Bone Neoplasms/pathology , Giant Cell Tumor of Bone/pathology , Toe Phalanges/pathology , Adolescent , Bone Neoplasms/surgery , Bone Substitutes/therapeutic use , Curettage , Giant Cell Tumor of Bone/surgery , Humans , Male , Toe Phalanges/surgery
12.
Clin Orthop Relat Res ; 467(11): 2825-30, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19384561

ABSTRACT

UNLABELLED: It has been argued that internal hemipelvectomy without reconstruction of the pelvic ring leads to poor ambulation and inferior patient acceptance. To determine the accuracy of this contention, we posed the following questions: First, how effectively does a typical patient ambulate following this procedure? Second, what is the typical functional capacity of a patient following internal hemipelvectomy? In the spring of 2006, we obtained video documentation of eight patients who had undergone resection arthroplasty of the hemipelvis seen in our clinic during routine clinical followup. The minimum followup in 2006 was 1.1 years (mean, 8.2 years; range, 1.1-22.7 years); at the time of last followup in 2008 the minimum followup was 2.9 years (mean, 9.8 years; range, 2.9-24.5 years). At last followup seven of the eight patients were without pain, and were able to walk without supports. The remaining patient used narcotic medication and a cane or crutch only occasionally. The mean MSTS score at the time of most recent followup was 73.3% of normal (range 53.3-80.0%; mean raw score was 22.0; range 16-24). All eight patients ultimately returned to gainful employment. These observations demonstrate independent painless ambulation and acceptable function is possible following resection arthroplasty of the hemipelvis. LEVEL OF EVIDENCE: Level IV, case series. See Guidelines for Authors for a complete description of levels of evidence.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Bone Neoplasms/surgery , Hemipelvectomy/methods , Pelvic Bones/surgery , Walking , Activities of Daily Living , Adolescent , Adult , Arthroplasty, Replacement, Hip/adverse effects , Bone Neoplasms/mortality , Bone Neoplasms/pathology , Chondrosarcoma/mortality , Chondrosarcoma/pathology , Chondrosarcoma/surgery , Cohort Studies , Female , Follow-Up Studies , Hemipelvectomy/adverse effects , Humans , Male , Neoplasm Staging , Osteosarcoma/mortality , Osteosarcoma/pathology , Osteosarcoma/surgery , Pain Measurement , Pelvic Bones/pathology , Quality of Life , Plastic Surgery Procedures/methods , Retrospective Studies , Risk Assessment , Sarcoma, Ewing/mortality , Sarcoma, Ewing/pathology , Sarcoma, Ewing/surgery , Survival Analysis , Treatment Outcome , Young Adult
13.
Int Orthop ; 33(1): 203-9, 2009 Feb.
Article in English | MEDLINE | ID: mdl-17724593

ABSTRACT

We retrospectively studied the functional and oncological results of 15 patients after reconstruction of the distal radius with osteoarticular allograft or non-vascularised fibular graft following wide excision of an aggressive benign or malignant tumour. Eight patients underwent osteoarticular allograft and seven patients had a non-vascularised autogenous fibular graft reconstruction. The average time for incorporation of the graft was 6 and 5 months in each reconstruction respectively. There was no tumour recurrence after follow up over 41.5-95.5 (average 60.5) months. All patients had good and excellent functional results. Three patients in the group reconstructed with osteoarticular allograft had plate loosening and graft fractures which were successfully treated subsequently.


Subject(s)
Bone Neoplasms/surgery , Bone Transplantation/methods , Giant Cell Tumor of Bone/surgery , Histiocytoma, Malignant Fibrous/surgery , Osteosarcoma/surgery , Radius/surgery , Adolescent , Adult , Bone Cysts/surgery , Bone Plates , Bone Transplantation/instrumentation , Female , Follow-Up Studies , Humans , Male , Middle Aged , Radiography , Radius/diagnostic imaging , Radius/physiology , Retrospective Studies , Treatment Outcome , Young Adult
14.
J Orthop Surg (Hong Kong) ; 17(3): 383-7, 2009 Dec.
Article in English | MEDLINE | ID: mdl-20065386

ABSTRACT

Malignant lower-limb metaphyseal and diaphyseal bone tumours that have not yet invaded the epiphysis can usually be managed with limb-sparing surgery. Reconstructions using intercalary allografts, autoclaved autografts, extracorporeally irradiated autografts, vascularised autografts, and distraction osteogenesis have all achieved favourable results. In patients with metastatic disease and a short life expectancy, reconstruction with allografts or autografts should be carefully considered because a long recovery period is needed. An intercalary endoprosthesis provides immediate stability, a short recovery period and a low implant failure rate. Nonetheless, it may be expensive when there is inadequate space for stem insertion, necessitating a custom-made endoprosthesis. We present a 12-year-old boy with stage-III osteosarcoma of the metaphysis and diaphysis of the femur who underwent knee joint salvage and reconstruction with a retrograde, locked, intramedullary nail surrounded with methylmethacrylate. At the one-month follow-up, the patient could walk unassisted. At the 2-year follow-up, his Musculoskeletal Tumor Society score was 83%. The patient died from lung metastases at 31 months. He had not experienced any complications with the reconstruction.


Subject(s)
Femoral Neoplasms/surgery , Knee Joint/surgery , Knee Prosthesis , Limb Salvage , Osteosarcoma/surgery , Bone Cements , Bone Nails , Child , Diagnostic Imaging , Fatal Outcome , Femoral Neoplasms/diagnosis , Femoral Neoplasms/pathology , Humans , Knee Joint/pathology , Male , Neoplasm Staging , Osteosarcoma/diagnosis , Osteosarcoma/pathology , Palliative Care
15.
J Med Assoc Thai ; 90(4): 706-17, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17487125

ABSTRACT

BACKGROUND: Nowadays, the results of the management of malignant bone and soft-tissue tumors have been dramatically improved because of the advance in imaging, chemotherapy, radiation therapy, and surgical techniques. Patients can have longer survival times with limb-salvage surgery. Several techniques of reconstruction have been advocated and gained more popularity following malignant tumor resection by using allograft, tumor prostheses, composite allograft prosthesis, or arthrodesis. OBJECTIVE: To report the preliminary results of 32 endoprosthetic reconstructions following malignant bone and soft-tissue tumor resection. The oncologic results, functional outcomes, and complications from the surgery were assessed in the present study. MATERIAL AND METHOD: Since September 1988, the authors have performed 188 limb-salvage surgical operations for the treatment of musculoskeletal tumors at Siriraj Hospital. From March 1994 to July 2006, 32 endoprosthetic reconstructions were performed on 30 patients following malignant bone or soft-tissue tumor removal. There were 16 males and 14 females with a mean age of 28 years (range 10-73). The diagnosis was conventional osteosarcoma in 16 patients, parosteal osteosarcoma in two patients, chondrosarcoma in two patients, leiomyosarcoma in two patients, failed allograft in two patients and one patient each of periosteal osteosarcoma, Ewing's sarcoma, Gorham's disease, synovial sarcoma, malignant fibrous histiocytoma, metastatic renal cell carcinoma, and prosthetic loosening. Wide excision was performed with a mean length of 18.5 cm (range 10-41). Five proximal femurs, 17 distal femurs, 1 total femur 3 proximal tibias, 1 intercalary tibia, 4 proximal humerus and 1 distal humerus were used for reconstruction. Modular replacement systems (MRS, Stryker/Howmedica/Osteonics) were the most common prostheses used in the present series. RESULTS: The mean follow-up time was 26 months (range 6-128.7). Sixteen patients are continuously free of the disease, two are alive with the disease, two had no evidence of the disease, nine died of the disease, and one patient died from complication of hypertension. The mean Musculoskeletal Tumor Society functional analysis for upper extremity reconstruction was 93% (range 86.7-100) and for lower extremity was 89% (range 63.3-100). Two patients (6.7%) were determined to be a failure. Revision due to aseptic loosening was performed in one patient (3.3%) and one hip disarticulation was done related to local recurrence (3.3%). One patient with sciatic nerve palsy and two seromas was found and successfully treated in the present study. CONCLUSION: Endoprosthetic reconstruction could yield satisfactory results as a wide excision and limb-salvage for patients with malignant bone and soft-tissue tumors. Most patients in the present report had good to excellent functions following surgery and few complications occurred in the present report.


Subject(s)
Bone Neoplasms/surgery , Limb Salvage , Osteosarcoma/surgery , Sarcoma, Ewing/surgery , Soft Tissue Neoplasms/surgery , Adolescent , Adult , Aged , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/rehabilitation , Child , Female , Humans , Male , Middle Aged , Osteosarcoma/diagnostic imaging , Osteosarcoma/rehabilitation , Prostheses and Implants , Prosthesis Implantation/methods , Radiography , Sarcoma, Ewing/diagnostic imaging , Sarcoma, Ewing/rehabilitation , Soft Tissue Neoplasms/diagnostic imaging , Soft Tissue Neoplasms/rehabilitation
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