Impact of COVID-19 on human immunodeficiency virus tests, new diagnoses, and healthcare visits in the Republic of Korea: a retrospective study from 2016 to 2021.

BACKGROUND: Public health workers have been at the forefront of treating patients with coronavirus disease 2019 (COVID-19) and managing the pandemic. The redeployment of this workforce has limited or interrupted other public health services, including testing for human immunodeficiency virus (HIV). This study aims to examine the impact of COVID-19 on HIV testing and diagnosis in the Republic of Korea from 2016 to 2021, comparing data before and after the onset of COVID-19. METHODS: Annual HIV testing data were collected from each institution through direct communication or from open-source databases. The annual number of new HIV cases was obtained from the official report of the Korea Disease Control and Prevention Agency. Data on healthcare visits for HIV diagnosis or treatment were extracted from the open-source database of the National Insurance Health Service of Korea. Interrupted time series regression was conducted, stratified by institution type. RESULTS: In 2020, HIV tests, diagnoses, and visits decreased. Notably, public health centers experienced a substantial reduction in 2020-2021 compared to previous years. The annual percentage change in HIV tests was -53.0%, while for HIV diagnoses, it was -31.6%. The decrease in visits for HIV was also most pronounced for public facilities: -33.3% in 2020 and -45.6% in 2021 relative to 2019. CONCLUSION: The numbers of tests, diagnoses, and healthcare visits for HIV at public health centers in the Republic of Korea substantially decreased in 2020 and 2021. The impacts of these changes on the early diagnosis and treatment of HIV necessitate further monitoring.

The effects of occupation-centered activity program on fall-related factors and quality of life in patients with dementia.

[Purpose] The purpose of this study was to investigate the effects of an occupation-centered activity program for dementia patients living in a local community, and examined the effects of the occupation-centered activity program on their cognitive functions, fall-related factors, and quality of life. [Subjects and Methods] Thirty subjects were divided into two groups: the experiment group (n=15) and the control group (n=15). The occupation-centered activity program was then applied to dementia patients for 60 minutes, 5 times/week for 12 weeks. To identify their cognitive functions before and after the intervention occupation-centered activity program, Mini-Mental State Examination-Korea (MMSE-K) and the Global Deterioration Scale (GDS) were used. To assess fall-related factors, Korean Falls Efficacy Scale for the Elderly (FES-K) was used and leg strength, agility, and balance of the participants was measured. To examine quality of life, the Korean version of Quality of Life-Alzheimer's Disease Scale (KQOL-AD) was used. [Results] The results of the intervention showed that although cognitive function improved in both the experimental and control groups, fall-related factors and the quality of life significantly improved only in the experimental group. [Conclusion] This indicates that the occupation-centered activity program had a positive effect on dementia patients' cognitive functions, fall-related factors, and quality of life.

The effects of repetitive transcranial magnetic stimulation (rTMS) on depression, visual perception, and activities of daily living in stroke patients.

[Purpose] The present study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on visual perception, depression, and activities of daily livings (ADLs) in stroke patients. [Subjects and Methods] Forty-four stroke patients were divided equally into an experimental group that underwent rTMS and a control group that underwent mock rTMS. Changes in patient visual perception, depression, and ADLs were evaluated. All subjects underwent treatment for 20 minutes, 5 times per week, for 4 weeks. Beck Depression Inventory (BDI), Motor-free Visual Perception Test (MVPT) and Functional Independent Measurement (FIM) were respectively used to assess depression, visual perception and ADLs. [Results] The experimental group showed significant improvements in depression, visual perception, and ADLs between week 1 and 4, between week 1 and 8, and between week 4 and 8. Meanwhile, the control group showed no differences between week 1 and 4, and although, like in the experimental group, a significant difference was observed in depression and visual perception between Week 1 and 8, there was no significant difference in ADLs. [Conclusion] These demonstrate that rTMS has a positive impact on visual perception, depression, and ADLs.

Effect of transcranial direct current stimulation of stroke patients on depression and quality of life.

[Purpose] The aim of this study was to assess the effects of transcranial direct current stimulation (tDCS) on depression and quality of life (QOL) in patients with stroke, by conducting conventional occupational therapy with and without tDCS on 20 patients each. [Subjects and Methods] The experimental group (N=20) received both tDCS and conventional occupational therapy, while the control group (N=20) received false tDCS and conventional occupational therapy. The treatment was conducted 20 times over a four-week period; each session was 30 minutes long. The Beck Depression Inventory (BDI) was administered to score the depression levels in patients before and after the intervention, while the stroke-specific quality of life (SS-QOL) was measured to compare the QOL. [Result] Following the intervention, the patients in the experimental group showed a significant decrease in depression and an increase in the QOL. In contrast, the control group showed no significant changes in depression or QOL. Our findings indicate that tDCS decreased depression while increasing QOL in patients with stroke. [Conclusion] In other words, our study confirmed that the application of tDCS during stroke rehabilitation improves the depression symptoms and QOL in patients.

Effect of transcranial direct current stimulation on visual perception function and performance capability of activities of daily living in stroke patients.

[Purpose] The purpose of this study was to examine the effects of transcranial direct current stimulation (tDCS) on visual perception and performance of activities of daily living in patients with stroke. [Subjects and Methods] Thirty subjects were assigned equally to a tDCS plus traditional occupational therapy group (experimental group) and a traditional occupational therapy group (control group). The intervention was implemented five times per week, 30 minutes each, for six weeks. In order to assess visual perception function before and after the intervention, the motor-free visual perception test (MVPT) was conducted, and in order to compare the performance of activities of daily living, the Functional Independence Measure scale was employed. [Results] According to the results, both groups improved in visual perception function and in performance of activities of daily living. Although there was no significant difference between the two groups, the experimental group exhibited higher scores. [Conclusion] In conclusion, the application of tDCS for the rehabilitation of patients with stroke may positively affect their visual perception and ability to perform activities of daily living.

The effects a respiration rehabilitation program on IADL, satisfaction with leisure, and quality of sleep of patients with chronic obstructive pulmonary disease.

[Purpose] This study was designed to determine the effect of a respiration rehabilitation program on daily activities, satisfaction with leisure, and quality of sleep of patients with chronic obstructive pulmonary disease. [Subjects and Methods] The program was conducted three times a week for 12 weeks (a total of 36 times) with 20 patients aged between 50 and 70 years old. The Frenchay Activity Index was used to determine the instrumental activities of daily living before and after the intervention. The Korean scale of satisfaction with leisure was employed to determine the satisfaction with leisure, and the Korean version of the Pittsburgh Sleep Quality Index was used to measure the quality of sleep. [Results] The total score of all three instruments (instrumental activities of daily living (IADL), satisfaction with leisure, and quality of sleep) improved significantly after the intervention. [Conclusion] In conclusion, the scores of all three instruments (IADL, satisfaction with leisure, and quality of sleep) improved significantly after the intervention, indicating that the respiration rehabilitation program was effective at improving the overall quality of life for patients with chronic obstructive pulmonary disease.

Effects of fictive reward on rat's choice behavior.

Choices of humans and non-human primates are influenced by both actually experienced and fictive outcomes. To test whether this is also the case in rodents, we examined rat's choice behavior in a binary choice task in which variable magnitudes of actual and fictive rewards were delivered. We found that the animal's choice was significantly influenced by the magnitudes of both actual and fictive rewards in the previous trial. A model-based analysis revealed, however, that the effect of fictive reward was more transient and influenced mostly the choice in the next trial, whereas the effect of actual reward was more sustained, consistent with incremental learning of action values. Our results suggest that the capacity to modify future choices based on fictive outcomes might be shared by many different animal species, but fictive outcomes are less effective than actual outcomes in the incremental value learning system.

Effect of orbitofrontal cortex lesions on temporal discounting in rats.

Although choices of both humans and animals are more strongly influenced by immediate than delayed rewards, methodological limitations have made it difficult to estimate the precise form of temporal discounting in animals. In the present study, we sought to characterize temporal discounting in rats and to test the role of the orbitofrontal cortex (OFC) in this process. Rats were trained in a novel intertemporal choice task in which the sequence of delay durations was randomized across trials. The animals tended to choose a small immediate reward more frequently as the delay for a large reward increased, and, consistent with previous findings in other species, their choice behavior was better accounted for by hyperbolic than exponential discount functions. In addition, model comparisons showed that the animal's choice behavior was better accounted for by more complex discount functions with an additional parameter than a hyperbolic discount function. Following bilateral OFC lesions, rats extensively trained in this task showed no significant change in their intertemporal choice behavior. Our results suggest that the rodent OFC may not always play a role in temporal discounting when delays are randomized and/or after extensive training.