ABSTRACT
OBJECTIVES: The purpose of this study was to assess myocardial blood flow (MBF) and flow reserve in systemic right ventricles (RV) in long-term survivors of the Mustard operation. BACKGROUND: There is a high prevalence of systemic RV dysfunction and impaired exercise performance in long-term survivors of the Mustard operation. A mismatch between myocardial blood supply and systemic ventricular work demand has been proposed as a potential mechanism. METHODS: We assessed MBF at rest and during intravenous adenosine hyperemia in 11 long-term survivors of a Mustard repair (age 18+/-5 years, median age at repair 0.7 years, follow-up after repair 17+/-5 years) and 13 healthy control subjects (age 23+/-7 years), using N-13 ammonia and positron emission tomography imaging. RESULTS: There was no difference in basal MBF between the systemic RV of survivors of the Mustard operation and the systemic left ventricle (LV) of healthy control subjects (0.80+/-0.19 vs. 0.74+/-0.15 ml/g/min, respectively, p = NS). However, the hyperemic flows were significantly lower in systemic RVs than they were in systemic LVs (2.34+/-0.0.69 vs. 3.44+/-0.62 ml/g/min respectively, p < 0.01). As a result, myocardial flow reserve was lower in systemic RVs than it was in systemic LVs (2.93+/-0.63 vs. 4.74+/-1.09, respectively, p < 0.01). CONCLUSIONS: Myocardial flow reserve is impaired in systemic RVs in survivors of the Mustard operation. This may contribute to systemic ventricular dysfunction in these patients.
Subject(s)
Coronary Circulation , Transposition of Great Vessels/surgery , Ventricular Dysfunction, Right/physiopathology , Adolescent , Adult , Child , Female , Follow-Up Studies , Heart/diagnostic imaging , Humans , Hyperemia/physiopathology , Male , Postoperative Period , Regional Blood Flow , Tomography, Emission-Computed , Ventricular Dysfunction, Right/diagnostic imagingABSTRACT
PURPOSE: Hepatobiliary scintigraphy is used routinely to evaluate infants with neonatal cholestasis. Hepatobiliary scintigraphy determines biliary patency by detecting radioactivity in the bowel on imaging, in duodenal and gastric aspirates, or all of these. During hepatobiliary scintigraphy, the hepatocyte extraction fraction (HEF) is calculated by deconvolution analysis. Normal values of HEF are more than 90%. It is believed that HEF may predict hepatic dysfunction, because, during hepatobiliary scintigraphy, the radiopharmaceutical used in this test is extracted by the hepatocytes from the blood stream. Therefore, a low value of HEF is seen with more severe hepatocellular disease. The goal of this study was to determine whether HEF has any correlation with synthetic liver function, whether HEF can differentiate obstructive from nonobstructive lesions that cause neonatal cholestasis, and whether HEF can predict the outcome of the different causes of neonatal cholestasis. METHODS: A retrospective analysis of 68 hepatobiliary scintigraphy results was done in patients with neonatal cholestasis for a period covering 6 years. RESULTS: The HEF was available in 67 of these 68 patients, with a median value of 25% (range, 3.3% to 100%). The results of synthetic liver function tests (i.e., albumin and prothrombin time) were normal in all infants with neonatal cholestasis. No significant correlation was detected between HEF and the serum levels of total and direct bilirubin, albumin, alkaline phosphatase, and prothrombin time by exploratory data analysis (R = 0.08; small, P > 0.2). The HEF values in different causes of neonatal cholestasis were compared: extrahepatic biliary atresia, neonatal hepatitis, and a miscellaneous category consisting of alpha1-antitrypsin deficiency, ischemic hepatitis, paucity of bile ducts, and others. The outcomes of these diseases were assessed as resolution, continuing disease, transplantation, or death, but no predictive correlation was found with HEF. CONCLUSIONS: A single determination of HEF is of no value in assessing synthetic liver function (as assessed by albumin and prothrombin time), specific diagnoses, and outcomes in patients with neonatal cholestasis. Therefore, a low isolated value of HEF should not be considered suggestive of poor prognosis and outcome in these patients.
Subject(s)
Biliary Tract/diagnostic imaging , Cholestasis/diagnostic imaging , Liver/diagnostic imaging , Bilirubin/analysis , Cholestasis/blood , Female , Fourier Analysis , Humans , Infant , Infant, Newborn , Male , Predictive Value of Tests , Radionuclide Imaging , Retrospective Studies , Serum Albumin/analysis , Technetium Compounds , Treatment OutcomeABSTRACT
We reviewed the records of 12 patients ages 9 to 16 years with knee osteochondritis dissecans. All patients had clinical histories and examinations, four radiographic views of the knee, and technetium-99m diphosphonate quantitative bone scans. Scan results (symmetric, increased, or decreased activity), clinical course, healing time, and final outcome were correlated to determine the prognostic value of the scan. We divided the patients into those with open physes (distal femoral and proximal tibial) and those with closed physes. Four of the six patients with open physes had increased activity on the bone scan. All four of these knees healed with nonsurgical treatment. The other two patients had decreased activity on bone scan, and both required surgical treatment after nonsurgical treatment failed. Of the six patients with closed physes, all had increased activity on the bone scan, but only two patients had healing of the osteochondral lesion without surgery. Quantitative bone scanning had a 100% predictive value for the prognosis in osteochondritis dissecans patients with open physes, but for those with closed physes the predictive value was less. Because the natural history in the adolescent group is less predictable, it is in this group that the quantitative scan would be most helpful. In this small group of patients, quantitative bone scanning had limited prognostic value.
Subject(s)
Knee/diagnostic imaging , Osteochondritis Dissecans/diagnostic imaging , Adolescent , Child , Female , Humans , Male , Predictive Value of Tests , Prognosis , Radiography , Radionuclide Imaging , Retrospective StudiesABSTRACT
BACKGROUND: In conventional radiography, a film-screen system serves as the X-ray detector and the film also functions as an archival and display medium. Unlike film-screen radiography, these functions are uncoupled in computed radiography (CR). CR uses conventional radiographic equipment to expose an image on a storage phosphor plate instead of a film-screen combination. OBJECTIVE: To review the basic concepts of CR and to provide a background for discussion of specific musculoskeletal applications of CR in children. MATERIALS AND METHODS: Various aspects of musculoskeletal CR in children are presented based on our 4 years' experience and a review of the literature. RESULTS: A greater amount of scatter capture occurs with storage phosphor CR than with a film-screen system in the 70- to 120-kVp range. This is attributed to a lower K-absorption edge of barium in the barium fluorohalide (BaFBr) compound used in the imaging plate. A significant reduction of scatter to primary radiation, improvement in bony trabecular sharpness, and improvement in line pair resolution can be achieved in pediatric musculoskeletal imaging using an air gap without an increase in the skin entrance dose as compared to the non-grid table top technique. With CR, in addition to proper radiographic exposure technique, one needs to preprogram and select the optimal processing technique for each anatomic region, projection and age group of the child. CONCLUSION: The main advantages of CR in pediatric musculoskeletal imaging consist of a reduction in radiation dose for many applications, improved contrast resolution, near elimination of repeat radiographs related to exposure errors, and digital processing capabilities for image enhancement, storage, retrieval, display and transmission. The current limitations of CR include the moderately high start-up cost, the long learning curve to produce optimal films, and the reduced spatial resolution.
Subject(s)
Bone and Bones/diagnostic imaging , Muscle, Skeletal/diagnostic imaging , Radiographic Image Enhancement , Artifacts , Child , Humans , Image Processing, Computer-Assisted , Radiation Dosage , Radiology Information SystemsABSTRACT
The effect of various air gaps on computed radiographic musculoskeletal images was investigated using a knee phantom. Scatter to primary radiation ratios were measured using the beam stop method at air gaps ranging from 0 to 30 in. (0-762-mm). Bony trabecular sharpness, line pair resolution, quantum mottle and visualization of low-contrast beads in the soft tissues were evaluated. A significant reduction of scatter to primary radiation ratio, from a value of almost 1 at table top to about 0.4 at 10-in. (254-mm) air gap and about 0.2 at 25-in. (635-mm) air gap placement of the computed radiography (CR) imaging plate, was obtained. A progressive improvement in bony trabecular sharpness and line pair resolution, compared with the table top and Bucky images was observed on 10-in. (254-mm) through 25-in. (635-mm) air gap images. Sharpness of the bony trabeculae and line pair resolution were best on the 25-in. (635-mm) air gap images. The skin entrance radiation dose does not have to be increased for air gap digital radiography. The radiographic noise or quantum mottle is highest on the Bucky image, higher on air gap images and minimal on the table top images, despite a high scatter to primary radiation ratio at the table top. The lower quantum mottle on the table top images allowed for maximal visualization of low contrast densities in the soft tissues. Air gap radiography further improves musculoskeletal computed imaging by reducing the scatter to primary radiation ratio without an increase in the skin entrance dose. For significant reduction of the scatter to primary radiation ratio and best evaluation of line pair spatial resolution and bony trabeculae, a 25-in. (635-mm) air gap with digital radiography would be optimal. For evaluation of low contrast densities in the soft tissues, table top placement would be the technique of choice.
Subject(s)
Bone and Bones/diagnostic imaging , Muscle, Skeletal/diagnostic imaging , Tomography, X-Ray Computed , Air , Artifacts , Child , Evaluation Studies as Topic , Humans , Image Processing, Computer-Assisted , Knee/diagnostic imaging , Observer Variation , Phantoms, Imaging , Radiation Dosage , Radiographic Image Enhancement/instrumentation , Radiographic Image Enhancement/methods , Scattering, Radiation , Skin/radiation effects , Tomography, X-Ray Computed/instrumentation , Tomography, X-Ray Computed/methods , X-Ray FilmABSTRACT
The role of single photon computed tomography (SPECT) in presurgical localization of medically intractable complex partial epilepsy (CPE) in children is reviewed. 99mTechnetium Neurolite, a newer lipophylic agent with a high first pass brain extraction and little or no redistribution is injected during a seizure, while the child is monitored with a video recording and continuous EEG and SPECT imaging is performed in the next 1-3 hours with the images representing regional cerebral profusion at the time of injection. On SPECT studies performed with radiopharmaceutical injected during a seizure, ictal focus is generally hypervascular. Other findings on ictal brain SPECT include hypoperfusion of adjacent cerebral cortex and white matter, hyperperfusion of contralateral motor cortex, hyperperfusion of ipsilateral basal ganglia and thalamus, brain stem and contralateral cerebellum. Ictal brain SPECT is non-invasive, cost effective and highly sensitive for localization of epileptic focus in patients with intractable CPE.
Subject(s)
Brain/diagnostic imaging , Seizures/diagnosis , Tomography, Emission-Computed, Single-Photon/methods , Child , Child, Preschool , Electroencephalography , Female , Humans , Infant , Male , Sensitivity and Specificity , Video RecordingABSTRACT
Geometrically magnified computed radiography (CR) chest radiographs can be obtained in children using the same techniques as for non-grid, non-magnified CR radiographs. The resulting magnification images have less scatter than grid images and better line pair resolution.
Subject(s)
Radiographic Image Enhancement , Radiography, Thoracic/methods , Adolescent , Child , Humans , Male , Phantoms, Imaging , Radiation Dosage , Radiography, Thoracic/instrumentationABSTRACT
The clinical diagnosis of hypoxic-ischemic brain injury in neonates can be supported by radiologic studies including cranial sonography, computed tomography (CT), single-photon emission computed tomography (SPECT), magnetic resonance imaging, and positron emission tomography. The role of cranial sonography, CT, and SPECT in term neonates with perinatal asphyxia is reviewed in this article.
Subject(s)
Asphyxia Neonatorum/diagnosis , Brain Ischemia/diagnosis , Echoencephalography , Tomography, Emission-Computed, Single-Photon , Tomography, X-Ray Computed , Adolescent , Adult , Asphyxia Neonatorum/complications , Asphyxia Neonatorum/epidemiology , Brain Ischemia/complications , Brain Ischemia/epidemiology , Cerebrovascular Circulation , Child , Humans , Infant, Newborn , Predictive Value of Tests , Prognosis , Risk FactorsABSTRACT
Neonatal skull depressions may occur from traumatic delivery or abnormal intrauterine position. Surgery has been recommended when the condition is thought to threaten neurologic development; however, normal neurologic outcomes have been observed in conservatively managed infants. A review of four patients with neonatal skull depression is presented together with the obstetric history and findings from nursery examinations, skull roentgenograms, electroencephalograms, and follow-up pediatric visits. Two patients underwent surgical elevation of the depression, while two children with depressions of similar severity were managed without intervention. Neurologic and cosmetic outcomes have been normal in all four patients. It is suggested that uncomplicated depressions should be treated conservatively, with surgical elevation reserved for neonates with intracranial complications.
Subject(s)
Birth Injuries/diagnosis , Skull/injuries , Birth Injuries/surgery , Cephalometry , Electroencephalography , Female , Follow-Up Studies , Humans , Infant, Newborn , Male , Neurologic Examination , Obstetrical ForcepsABSTRACT
The enthesopathy (bone proliferation at sites of ligament, tendon, joint capsule, and interosseous membrane attachment) that may be present in adults who have longstanding hypophosphatemic osteomalacia, the most common type of osteomalacia, has received little attention in the radiologic literature. These proliferative enthetic changes may be associated with various musculoskeletal symptoms. The spectrum of proliferative enthesopathic changes, involving the axial and appendicular skeleton, is described in six patients 18-63 years old. Proliferative changes at the attachment of the annulus fibrosus were present in six of six patients and ranged in extent from tiny hyperostoses at a few levels to thin marginal symmetric syndesmophytes involving the entire lumbosacral spine and mimicking spondylitis. Thoracic spinal syndesmophytes were present in four patients and cervical hyperostoses of various magnitudes were present in three patients. Changes in the sacroiliac joints were present in four of six patients and varied from mild widening to symmetric intraarticular and anterior paraarticular bony bridging. Proliferative enthesopathy involving the pelvis and proximal femora was present in six of six patients. Appendicular changes included accessory ossicles within the wrist and hands and bony proliferation of the distal radius and metacarpal heads. These were noted in four patients. Ossification of the interosseous membrane of the forearms or the lower extremities was present in six patients and paraarticular bony proliferation about the elbows was noted in four patients. It is apparent that the severity of the enthesopathy that occurs may vary, and that hypophosphatemic osteomalacia should be recognized as a cause of enthesopathy even if other radiographic findings of osteomalacia may not be present on available radiographs.
Subject(s)
Ossification, Heterotopic/diagnostic imaging , Osteomalacia/diagnostic imaging , Phosphates/blood , Adolescent , Adult , Arthrography , Female , Humans , Ligaments/diagnostic imaging , Male , Middle Aged , Muscles/diagnostic imaging , Ossification, Heterotopic/etiology , Osteomalacia/etiology , Spine/diagnostic imagingABSTRACT
A case of bilateral anterior shoulder dislocation accompanied by bilateral brachial plexus injuries is presented. A 53-year-old man fell and landed on his chest and arms flexed at the elbows. The dislocations were satisfactorily reduced using the forward elevation, flexion maneuver. Electromyography and nerve conduction studies confirmed bilateral brachial plexus lesions. Arthrogram of the right shoulder demonstrated a rotator cuff tear. The patient is undergoing physical therapy and making a slow recovery.
Subject(s)
Brachial Plexus/injuries , Shoulder Dislocation/complications , Humans , Male , Middle Aged , Radiography , Shoulder Dislocation/diagnostic imaging , Shoulder Dislocation/therapyABSTRACT
Dystonic extrapyramidal reactions due to neuroleptic medications are a common entity in emergency medicine. However, it is not widely reported that dystonia can be associated with airway compromise and death. We describe a case of upper airway obstruction due to a dystonic reaction to haloperidol, present radiographic evidence of airway compromise, and explain the physiologic mechanisms involved.
Subject(s)
Airway Obstruction/diagnosis , Dystonia/diagnosis , Adult , Antipsychotic Agents/adverse effects , Diagnosis, Differential , Diphenhydramine/therapeutic use , Dystonia/chemically induced , Female , Haloperidol/adverse effects , HumansABSTRACT
Though generally nonspecific, the patterns of diaphyseal uptake of bone seeking radionuclides, when correlated with the radiographic findings and clinical histories, often suggest specific diagnoses and may obviate the need for further imaging. Diaphyseal uptake is considered in terms of "hot spots," unilateral long segment lesions and bilateral processes that may be symmetric or asymmetric in distribution. Scintigrams and corresponding radiographs of 18 different lesions are illustrated.
Subject(s)
Bone Diseases/diagnostic imaging , Bone Neoplasms/diagnostic imaging , Humans , Radiography , Radionuclide ImagingABSTRACT
Appendiceal disease can be acute, acute recurrent, or chronic. Acute appendicitis is the most common form. Acute recurrent appendicitis is more common than chronic appendicitis. In children the clinical manifestations of appendicitis are variable. Patients who have an appendicolith usually develop appendicitis, often with perforation. A case is presented of 3-year follow-up of a patient with an appendicolith and acute recurrent appendicitis. The literature about appendicoliths is reviewed. In the appropriate clinical setting, a history of prior episodes of similar right lower quadrant pain does not preclude the diagnosis of appendiceal disease. Awareness of the less common forms of appendicitis is important so that appropriate treatment is not delayed.
Subject(s)
Appendicitis/complications , Calcinosis/complications , Cecal Diseases/complications , Appendectomy , Appendicitis/diagnostic imaging , Appendicitis/physiopathology , Calcinosis/diagnostic imaging , Calcinosis/physiopathology , Cecal Diseases/diagnostic imaging , Cecal Diseases/physiopathology , Child , Humans , Male , Radiography , RecurrenceSubject(s)
Gigantism/diagnostic imaging , Adolescent , Humans , Lipomatosis/diagnostic imaging , Male , Radiography , SyndromeABSTRACT
We report a case of acute, noncardiogenic pulmonary edema in an 11-year-old boy who suffered strangulation during an altercation. The clinical presentation was characterized by moderate respiratory distress and hemoptysis. Both the radiographic and clinical findings resolved during the three day admission which followed. A review of the literature is presented, and possible pathogenesis is discussed.