ABSTRACT
UNLABELLED: Endometriosis is a disease of high prevalence and enigmatic origin. One aspect not yet clarified is the relationship between endometriosis and nerve tissue. OBJECTIVE: To evaluate, by immunohistochemistry, the presence of sympathetic and parasympathetic nerve fibers in the uterosacral ligament and adjacent connective tissue in women with deep pelvic endometriosis and women without endometriosis. DESIGN: Cross-sectional study (Canadian Task Force II). SETTING: University Hospital. Obstetrics and Gynecology Department, Santa Casa Medical School, São Paulo, Brazil. METHODOLOGY: We selected 49 patients, 20 of them with deep endometriosis in the uterosacral ligament and 29 patients without endometriosis. Secondary antibodies to NSE (pan-neuronal marker), NPY (that identifies sympathetic nerve fibers), and VIP (that identifies parasympathetic nerve fibers) were used for the immunohistochemistry analyses. RESULTS: The immunohistochemical staining by the NSE antibody was positive in 40% of cases of women with endometriosis and in 20.7% of patients without endometriosis (non-significant). The immunohistochemical staining by the NPY antibody was positive in 60% of patients with endometriosis and in 20.7% of the control group (p=0.005), while staining by the VIP antibody was 60% in patients with endometriosis and 13.8% in patients without endometriosis (p=0.001). CONCLUSION: Immunoexpression of NPY (sympathetic fibers) and VIP (parasympathetic fibers) is higher in women with deep pelvic endometriosis than in women without endometriosis.
Subject(s)
Endometriosis/etiology , Ligaments/innervation , Nerve Fibers/chemistry , Adult , Cross-Sectional Studies , Endometriosis/pathology , Female , Humans , Immunohistochemistry , Neuropeptide Y/analysis , Phosphopyruvate Hydratase/analysis , Sacrum/innervation , Uterus/innervation , Vasoactive Intestinal Peptide/analysisABSTRACT
Säo descritos dois casos de aneurismas rotos de artérias esplâncnicas, um em artéria gástrica esquerda em doente de 62 anos e outro em artéria cólica média em doente de 58 anos, ambos do sexo masculino e que deram entrada em pronto-socorro com abdome agudo hemorrágico. O diagnóstico correto, no entanto, só foi possível após a laparotomia exploradora. O estudo anatomopatológico demonstrou tratar-se de aneurismas de etiologia arteriosclerótica. Poucas säo as descriçöes de anerismas rotos, praticamente näo se tendo encontrado citaçöes de rupturas de aneurismas em artérias gástrica esquerda ou cólica média na literatura nacional
Subject(s)
Middle Aged , Humans , Male , Abdomen, Acute/etiology , Aneurysm/complications , Gastrointestinal Hemorrhage/etiology , Mesenteric Arteries , Rupture, SpontaneousABSTRACT
Alguns trabalhos na literatura têm detectado alteraçöes significativas em músculo de animais desnutridos. No entanto, poucos säo os etudos que analisam as alteraçöes no músculo esquelético do homem. Foram estudados 24 pacientes com diferentes graus de desnutriçäo, 14 com neoplasias malignas e 10 com afecçöes näo neoplásicas. Os doentes foram submetidos à avaliaçäo nutricional e biópsia muscular, tendo por objetivo estudar as alteraçöes em músculo esquelético de desnutrido e correlacionar com graus de desnutriçäo. Neste grupo boservou-se amiotrofia neurogênica de graus variados em 23 e, em um, miosite paraneoplásica. Os resultados obtidos sugerem correlaçäo entre as alteraçöes morfológicas e histoquímicas com a desnutriçäo