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Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant.

Halac, Ugur; Béland, Kathie; Lapierre, Pascal; Patey, Natacha; Ward, Pierre; Brassard, Julie; Houde, Alain; Alvarez, Fernando.

J Pediatr ; 160(5): 871-4.e1, 2012 May.

Article in English | MEDLINE | ID: mdl-22341950

ABSTRACT

Chronic hepatitis E virus (HEV) infection occurs in immunosuppressed adults. We detected HEV ribonucleic acid in serum of an adolescent patient who had undergone bone marrow transplantation and subsequently presented with persistently increased aminotransferases and histologic chronic hepatitis, and eventually developed cirrhosis. Phylogenetic analysis revealed these HEV strains were similar to swine genotype 3a, suggesting a possible zoonosis.

Subject(s)

Bone Marrow Transplantation/adverse effects , Hepatitis E/diagnosis , Immunocompromised Host , Liver Cirrhosis/virology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/surgery , Adolescent , Antiviral Agents/therapeutic use , Biopsy, Needle , Bone Marrow Transplantation/immunology , Chronic Disease , Disease Progression , Follow-Up Studies , Hepatitis E/drug therapy , Hepatitis E/immunology , Hepatitis E virus/drug effects , Hepatitis E virus/isolation & purification , Humans , Immunohistochemistry , Liver Cirrhosis/pathology , Liver Function Tests , Male , Postoperative Complications/diagnosis , Postoperative Complications/therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Risk Assessment , Severity of Illness Index , Transaminases/metabolism

ABSTRACT

Subject(s)

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