ABSTRACT
Human adenovirus ( HAdV ) is the most widely used vector of gene drugs . Its applications range from oncolytic therapy to vaccination , besides , HAdV is one of the most important pathogen causing acute respiratory infections in infants and young children .How the human innate immune system protects against HAdV has always been the focus of its application as a vaccine carrier .In patients with immunodeficient and hematopoietic stem cell transplant , specific T cell immunotherapy is also one of the hotspots in recent years .Although some HAdV vector vaccines have entered clinical trials , the immune mechanism remains controversial .This article describes how the human innate immune system and the adaptive immune system defend against HAdV and the escape mechanism of HAdV for human immune responses ,in order to indicate directions for vaccine research and deepen clinicians 'understanding of HAdV severe infections .
ABSTRACT
Hepatitis B virus(HBV)infection is the main cause of chronic liver diseases in China. The clearance of HBV is important for patients with chronic hepatitis B.Current antiviral therapy includes interferon and nucleotide analogues.The adverse reactions of interferon are common which restrict its application.Nucleotide analogues need long-term maintenance treatment.Kupffer cells (KCs) are the main innate immune cells in the liver.Studies have shown that KCs play an important role in hepatitis B virus infection.It can inhibit virus replication effectively , but may also result in immune dysfunction , causing HBV persistence.Understanding the mechanism related to the role of KCs in hepatitis B virus infection may lead to a new approach of antiviral therapy.