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J Pediatr ; 126(2): 269-71, 1995 Feb.
Article in English | MEDLINE | ID: mdl-7844677

ABSTRACT

We investigated the loss of detectable antibody directed against the hepatitis B surface antigen after immunization with hepatitis B vaccine in 55 patients who were seronegative for the human immunodeficiency virus and had hemophilia. Twenty percent of patients lost detectable antibody at a mean of 4.6 years after completion of immunization. Monitoring of hepatitis B serostatus or routine revaccination may be necessary.


Subject(s)
HIV Seronegativity/immunology , HIV-1/immunology , Hemophilia A/immunology , Hepatitis B Antibodies/blood , Hepatitis B Surface Antigens/immunology , Hepatitis B Vaccines/immunology , Child , Child, Preschool , Humans , Immunization , Infant , Philadelphia , Retrospective Studies , Time Factors
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