ABSTRACT
Background: Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear. Methods: A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels. Results: In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs. There was no correlation between these connectivities and HD symptoms. Conclusions: Although the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies. These findings provide new insight into the neurobiological basis of HD.
ABSTRACT
By incorporating inert KCl into the Na2IrO3+ 2CuCl â Cu2IrO3+ 2NaCl topochemical reaction, we significantly reduced the synthesis temperature of Cu2IrO3from the 350 °C reported in previous studies to 170 °C. This adjustment decreased the Cu/Ir antisite disorder concentration in Cu2IrO3from â¼19% to â¼5%. Furthermore, magnetic susceptibility measurements of the present Cu2IrO3sample revealed a weak ferromagnetic-like anomaly with hysteresis at a magnetic transition temperature of â¼70 K. Our research indicates that the spin-disordered ground state reported in chemically disordered Cu2IrO3is an extrinsic phenomenon, rather than an intrinsic one, underscoring the pivotal role of synthetic chemistry in understanding the application of Kitaev model to realistic materials.