ABSTRACT
Although play is an essential occupation for children, parents of children with autistic traits tend to struggle with play-based interpersonal interaction with them. Tickling play appears to be one of the most interpersonal forms of play because nobody can tickle themselves. However, atypical tactile processing (e.g. tactile sensitivity) has been reported in children with autistic traits, who may exhibit atypical behavioral responses during tickling play. Our aim was to investigate the association between autistic traits and behavioral responses during parent-child tickling play in Japanese young children. We recorded tickling interaction between children and their parents using behavior coding with six behavioral items. Autistic traits and tactile sensitivity were measured using parent-reported questionnaires. Results showed two behavioral responses were significantly associated with autistic traits in all children: "approach with positive emotional response" and "no response" were negatively and positively correlated with autistic traits, respectively. This exploratory study suggests that behavioral responses during tickling play may be associated with autistic traits.
Subject(s)
Autistic Disorder , Humans , Male , Female , Japan , Child, Preschool , Play and Playthings , Child , Surveys and Questionnaires , Parent-Child Relations , Child Behavior , Touch , East Asian PeopleABSTRACT
PURPOSE: With the current study, we aimed to reveal the similarities and differences in sensory profiles between Williams syndrome (WS) and autism spectrum disorder. METHODS: Using the sensory profile questionnaire completed by the caregivers, we analyzed the WS (n = 60, 3.4-19.8 years) and autistic (n = 39, 4.2-14.0 years) groups. RESULTS: The Severity Analysis revealed a significant group difference in Sensory Sensitivity but not in Low Registration, Sensation Seeking, and Sensation Avoiding subscales. Age can modulate the subscale scores differently across groups. For Sensation Seeking, the scores of both groups decreased with development. However, the scores of Sensory Sensitivity decreased with age in the autistic group but not in the WS group. Sensation Avoiding scores increased with development in the WS group but not in the autistic group. No significant developmental changes were observed in Low Registration. CONCLUSION: This study highlights the cross-syndrome similarities and differences in sensory profiles and developmental changes in autistic individuals and individuals with WS.
ABSTRACT
Vertical migration as well as horizontal dispersion is important in the ecological strategy of planktonic larvae of sedentary corals. We report in this paper unique vertical swimming behavior of planulae of the reef-building coral Acropora tenuis. Several days after fertilization, most of the planulae stayed exclusively at either the top or the bottom of the rearing tank. A good proportion of the planulae migrated almost vertically between top and bottom with fairly straight trajectories. Planulae sometimes switched their swimming direction via a sharp turn between the opposite directions. Quantitative analyses demonstrated that planulae kept constant speed while swimming either upward or downward, in contrast to frequent changes of direction and speed in horizontal swimming. Statistical comparison of propulsive speeds, estimated from swimming speeds and passive sedimentation, revealed gravikinesis of planulae, where the propulsive speed was significantly greater in downward swimming than upward swimming. The larval density hydrodynamically estimated was 0.25% lower than sea water density, which might be explained by the large quantity of lipids in planulae. Also, the deciliated larvae tended to orient oral end-up during floatation, presumably due to asymmetrical distribution of the endogenous light lipids. Plasticity of the larval tissue geometry could easily cause relocation of the center of forces which work together to generate gravitactic-orientation torque and, therefore, abrupt changing of the gravitactic swimming direction. The bimodal gravitactic behavior may give a new insight into dispersal and recruitment of coral larvae.
Subject(s)
Anthozoa , Animals , Larva , Swimming , Seawater , LipidsABSTRACT
Generally, when individuals attempt to move two limbs rhythmically in the opposite direction (e.g., flex the left hand and extend the left foot along the sagittal plane), the movements tend to be instead performed in the same direction. This phenomenon, known as directional constraint, can be harnessed to examine the difficulties in movement coordination exhibited by most individuals with autism spectrum disorder (ASD). While such difficulties have already been investigated through standardized clinical assessments, they have not been examined through kinematic methods. Thus, we employed a clinical assessment scale in an experimentally controlled environment to investigate whether stronger directional constraint during the rhythmic movement of two limbs is more pronounced and associated with decreased movement coordination in individuals with ASD. ASD and typically developing (TD) participants were asked to rhythmically move two limbs either in the same or opposite directions. In addition, the coordination skills of participants were assessed using the Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2). Subjects with ASD showed significantly stronger directional constraint than TD participants during the contralateral and ipsilateral movement of the hand and foot. According to the pooled data from both groups, participants who showed stronger directional constraint during these two movement conditions also exhibited poorer coordinated movement skills in the BOT-2. These results suggest that people with ASD may have difficulties in inhibiting the neural signals that synchronize the direction of inter-limb movements, thus resulting in coordination disabilities. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) often exhibit difficulties in coordinated movements. We asked those with ASD and typically developing (TD) participants to move two limbs (e.g., left hand and left foot) either in the same or the opposite direction. Results demonstrated that participants with ASD had more difficulties in counteracting the tendency of their hand and foot to synchronously move in the same direction. Our findings suggested that difficulties to suppress synchronized movements of the hand and foot result in coordination disabilities.
Subject(s)
Autism Spectrum Disorder , Humans , Autism Spectrum Disorder/complications , Movement , HandABSTRACT
The Interoception Sensory Questionnaire (ISQ) is a self-report instrument used to assess the characteristics of interoceptive processing in individuals with autism spectrum disorder (ASD). Previous studies have shown that scores of the ISQ are more appropriate than other subjective measures for evaluating difficulties in interoceptive processing in individuals with ASD. Yet, no prior research has demonstrated the validation of the ISQ in Japanese samples. This study attempted to validate the Japanese version of the ISQ (ISQ-J) by examining its psychometric properties. We confirmed the score distribution, internal consistency, and factor structure in Japanese samples. We also examined the relationships with other interoceptive questionnaires. In addition, we compared the scores of the ISQ-J between adolescents and adults with ASD participants and control participants. Results of confirmatory factor analyses showed that the reliability of the ISQ-J in adults with ASD reached an acceptable level of a one-factor structure with excellent internal consistency (α = 0.963). The result of the ISQ-J showed a significant positive correlation with the measure of awareness of interoceptive sensitivity for localized bodily states; on the other hand, a significant negative correlation was found with those integrated bodily states. In addition, the ISQ-J scores were significantly higher in the ASD group than in the control group. The current findings depend on self-report data (including a diagnosis of ASD) to measure validity constructs. Additionally, since the ISQ-J was surveyed in adults with ASD, it is unclear whether similar the results would be obtained if the ISQ-J were conducted with children. These results indicate the validity and reliability of the ISQ-J and provide a tool for assessing confusion of interoceptive information in Japanese adults with ASD.
Subject(s)
Autism Spectrum Disorder , Interoception , Adolescent , Adult , Child , Humans , Autism Spectrum Disorder/diagnosis , East Asian People , Psychometrics , Reproducibility of Results , Surveys and Questionnaires , Language , JapanABSTRACT
This study examined the similarities/differences between the social phenotypes of Williams syndrome (WS) and autism spectrum disorder (ASD). As cultural norms may affect symptom evaluation, this study administered the Social Responsiveness Scale-2 to Japanese individuals with WS (n = 78, 4.4-44.0 years) and ASD (n = 75, 4.7-55.4 years). The scores for Social Motivation and Social Communication were significantly more severe in the ASD than WS group. Overall, the similarities and differences between the social phenotypes of the syndromes were consistent with the findings of a recent study conducted in the UK, except for the social awareness subscale score. This highlights the importance of cross-cultural investigations of WS and ASD.
ABSTRACT
Atypical sensory features are frequently observed in individuals with autism spectrum disorder (ASD) as uncontrollable and less predictable sensory stimuli are thought to be stressful for them. To quantify distal indicators of cardiac vagus nerve activity, which is associated with top-down self-regulatory capacity, during sensory tasks as a stress state in children with ASD, we conducted an exploratory study to measure phasic high-frequency components of heart rate variability (phasic HF-HRV) during less controllable tactile/auditory sensory tasks in 37 children with ASD (aged 6-12 years) and 37 typically developing (TD) children. Only children with ASD showed increased HF-HRV values from the resting state to the task (i.e., phasic HF-HRV augmentation) during both less controllable tactile/auditory sensory tasks. In TD children, decreased phasic HF-HRV values were observed to cope with the task demand during the less-controllable-tactile task. These findings suggest that increased phasic HF-HRV values in response to less controllable sensory stimuli may reflect atypical physiological regulation during sensory stimulation in children with ASD.
Subject(s)
Autism Spectrum Disorder , Child , Humans , Autism Spectrum Disorder/complications , Touch , Heart Rate/physiologyABSTRACT
Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using 1H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism.
Subject(s)
Autism Spectrum Disorder/metabolism , Motor Cortex/metabolism , gamma-Aminobutyric Acid/metabolism , Adolescent , Adult , Brain/metabolism , Female , Humans , Magnetic Resonance Spectroscopy , Male , Neural Inhibition/physiology , Young AdultABSTRACT
BACKGROUND: Williams syndrome (WS) is a neurodevelopmental disorder that has been attributed to heterozygous deletions in chromosome 7q11.23 and exhibits a variety of physical, cognitive, and behavioral features. However, the genetic basis of this phenotypic variability is unclear. In this study, we identified genetic clues underlying these complex phenotypes. METHODS: Neurobehavioral function was assessed in WS patients and healthy controls. Total RNA was extracted from peripheral blood and subjected to microarray analysis, RNA-sequencing, and qRT-PCR. Weighted gene co-expression network analysis was performed to identify specific alterations related to intermediate disease phenotypes. To functionally interpret each WS-related module, gene ontology and disease-related gene enrichment were examined. We also investigated the micro (mi)RNA expression profiles and miRNA co-expression networks to better explain the regulation of the transcriptome in WS. RESULTS: Our analysis identified four significant co-expression modules related to intermediate WS phenotypes. Notably, the three upregulated WS-related modules were composed exclusively of genes located outside the 7q11.23 region. They were significantly enriched in genes related to B-cell activation, RNA processing, and RNA transport. BCL11A, which is known for its association with speech disorders and intellectual disabilities, was identified as one of the hub genes in the top WS-related module. Finally, these key upregulated mRNA co-expression modules appear to be inversely correlated with a specific downregulated WS-related miRNA co-expression module. CONCLUSIONS: Dysregulation of the mRNA/miRNA network involving genes outside of the 7q11.23 region is likely related to the complex phenotypes observed in WS patients.
Subject(s)
Autism Spectrum Disorder/genetics , Gene Expression Profiling , Gene Expression/genetics , Williams Syndrome/genetics , Child , Chromosomes, Human, Pair 7/genetics , Humans , MicroRNAs/genetics , RNA, Messenger/geneticsABSTRACT
PURPOSE: Oxaliplatin, an important chemotherapeutic agent in colorectal cancer, causes chemotherapy-induced peripheral neuropathy (CIPN), for which prophylactic or therapeutic interventions are lacking. We aimed to investigate changes in upper extremities, activities of daily living (ADL), and health-related quality of life (HRQoL) parameters after the first chemotherapy cycle. METHODS: Thirty-eight colorectal cancer patients scheduled to receive the leucovorin, 5'-fluorouracil, oxaliplatin (FOLFOX) therapy or the capecitabine, oxaliplatin (CAPOX) therapy, participated. Patients underwent objective assessment of sensory function, muscular strength, and manual dexterity and answered the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and the Disabilities of the Arm, Shoulder, and Hand-Disability/Symptom (DASH-DS) questionnaires for subjective assessment. The CIPN was assessed at baseline and prior to the second drug cycle. RESULTS: Light touch sensation in both hands worsened significantly after the first drug cycle, though no significant changes were observed in muscular strength and manual dexterity. The QLQ-C30 analysis showed that Physical Functioning, Role Functioning, Nausea and Vomiting, and Dyspnea were significantly worse, whereas Emotional Functioning was improved. The DASH-DS analysis revealed significant worsening of dysfunction and subjective symptoms. CONCLUSIONS: Our results suggest that light touch sensation may worsen even in the absence of multiple chemotherapy cycles. Even if arm and hand function (muscular strength and manual dexterity) is apparently intact, patients may experience dysfunction and decreased HRQoL. For preserving or improving patients' ADL and HRQoL, it is imperative to provide support at chemotherapy initiation.
Subject(s)
Activities of Daily Living/psychology , Colorectal Neoplasms/drug therapy , Oxaliplatin/adverse effects , Peripheral Nervous System Diseases/chemically induced , Quality of Life/psychology , Upper Extremity/blood supply , Adult , Aged , Colorectal Neoplasms/pathology , Female , Humans , Male , Middle Aged , Oxaliplatin/pharmacology , Prospective StudiesABSTRACT
Ideation is an essential central concept in sensory integration theory. The Test of Ideational Praxis (TIP) (May-Benson, ) is the first instrument developed to specifically assess children's ideational abilities but qualitative differences of its performance are not well examined. The purpose of the present study was to explore the components of ideational abilities that influenced the TIP score or its developmental change. The TIP was administered to 119 Japanese preschoolers, aged 3-6 years. The demonstrated actions were categorized based on the scoring criteria, and scores were calculated by summing the number of actions. Correspondence analysis was conducted to summarize the data into several components. Results indicate that conventionality and intentionality are contributors to ideational abilities in preschoolers. Conventionality was significantly related to the development of ideation, while intentionality was significantly associated with the TIP score. These results suggest that action differences during the TIP, in addition to the score, may be helpful for interpreting the results of the TIP when it is used clinically. Although the data does not sufficiently explain these two components, the results add new evidence for understanding preschoolers' ideational praxis. Further research is needed on factors related to the TIP score and development of ideational abilities. Copyright © 2016 John Wiley & Sons, Ltd.
Subject(s)
Child Development , Concept Formation , Perception , Child , Child, Preschool , Female , Humans , Male , Occupational TherapyABSTRACT
Teacher-child relationships (TCRs) are important factors in socio-emotional development and academic and behavioural outcomes. In Japan, occupational therapists (OTs) work with teachers and children with intellectual disabilities (ID) in school environment considering TCRs. This study aimed to identify positive indicators in TCRs among children with ID. We conducted interviews with 23 Japanese preschool teachers working with children with ID in child development support centres (CDSCs) and used the Delphi method to evaluate and select positive indicators. We obtained 49 positive indicators belonging to 15 conceptual indicators related to TCRs. The indicators that reached a high degree of agreement and consensus seems to be related to more fundamental social interaction aspects. These indicators could be used to enhance collaboration between OTs and teachers in the school environment, including CDSCs. We could not examine differences of positive social aspects depending on diagnostic features. It will be important for future work to examine differences in positive social aspects among children with other diagnostic features. Our findings could contribute to the development of an assessment tool to evaluate positive aspects of teacher-child interactions and their progress.