1.
Josai Shika Daigaku Kiyo
; 13(2): 428-36, 1984.
Article
in Japanese
| MEDLINE
| ID: mdl-6596994
Subject(s)
Health Education, Dental , Oral Hygiene , Adolescent , Child , Child, Preschool , Humans , Infant , Mexico , Mother-Child Relations , Rural Health , Urban Health
2.
Josai Shika Daigaku Kiyo
; 12(2): 224-30, 1983.
Article
in Japanese
| MEDLINE
| ID: mdl-6585247
Subject(s)
Health Education, Dental , Oral Hygiene , Adolescent , Child , Child, Preschool , Dental Care , Female , Humans , Male , Mexico , Mother-Child Relations , United States
3.
Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient.
J Pediatr
; 96(3 Pt 1): 479-84, 1980 Mar.
Article
in English
| MEDLINE
| ID: mdl-7359247
ABSTRACT
Michaelis-Menten pharmacokinetics were evaluated for diphenylhydantoin given to 104 patients 0.5 to 16 years of age with seizures. A method for individualizing the dosage regimen of DPH for each patient was evaluated retrospectively. The Vmax was inversely related to age (r = 0.552, P less than 0.001) but there was no such relationship for Km. The individual pharmacokinetics were characteristic of that person and could be used to adjust dosage so that toxicity would be avoided. We present a nomogram for adjusting the dosage of DPH in the pediatric age groups.