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1.
Int J Gynaecol Obstet ; 148(1): 113-117, 2020 Jan.
Article in English | MEDLINE | ID: mdl-31593299

ABSTRACT

OBJECTIVE: To evaluate the safety and efficacy of flushing the cervical canal and the uterine cavity with local anesthetic in order to reduce the pain felt by patients during office hysteroscopy. METHODS: A double-blind randomized controlled trial was conducted between May 1, 2018, and February 28, 2019, involving 260 women undergoing office hysteroscopy at Kasr Al Ainy Hospital, Cairo, Egypt. Women were randomized using a computerized random number generator to intrauterine and intracervical instillation 5 minutes before the procedure of either 5 mL lidocaine 2% diluted in 15 mL normal saline, or 20 mL normal saline alone. The primary outcome measure was the visual analog scale (VAS) pain score reported by women during the procedure. Secondary outcomes included VAS score at 10 and 30 minutes after the procedure, the need for analgesia, and occurrence of vasovagal attacks. RESULTS: Women in the lidocaine flushing group reported a significantly lower VAS score during the procedure (1.8 ± 1.1 vs 5.2 ± 1.8) and 10 and 30 minutes after it (1.3 ± 1.15 and 0.8 ± 0.9 vs 4.3 ± 2.1 and 2.98 ± 1.96) when compared with control women (P<0.001). More women without lidocaine flushing experienced vasovagal attacks (25/130 vs 9/130, P<0.001) and needed analgesia (84/130 vs 13/130, P<0.001) when compared with women with lidocaine flushing. CONCLUSION: Flushing of the cervical canal and uterine cavity with local anesthetic significantly decreased pain sensation in women undergoing office hysteroscopy. CLINICALTRIALS.GOV: NCT03530488.


Subject(s)
Anesthesia, Local/methods , Anesthetics, Local/administration & dosage , Hysteroscopy/methods , Lidocaine/administration & dosage , Adult , Double-Blind Method , Egypt , Female , Humans , Middle Aged , Pain Management/methods , Pregnancy , Preoperative Care/methods
2.
Int J Gynaecol Obstet ; 140(2): 211-216, 2018 Feb.
Article in English | MEDLINE | ID: mdl-29048754

ABSTRACT

OBJECTIVE: To assess whether endometrial injury in the cycle preceding controlled ovarian hyperstimulation during intracytoplasmic sperm injection (ICSI) improves the implantation and pregnancy rates. METHODS: Between January 1, 2016, and March 31, 2017, a randomized controlled trial was conducted at a center in Egypt among 300 women who met inclusion criteria (first ICSI cycle, aged <40 years, day-3 follicle-stimulating hormone <10 IU/L, normal serum prolactin, no uterine cavity abnormality). The women were randomly allocated using a web-based system to undergo endometrial scratch in the cycle preceding controlled ovarian hyperstimulation (n=150) or to a control group (n=150). Only data analysts were masked to group assignment. The primary outcomes were the implantation and clinical pregnancy rates at 14 days and 4 weeks after embryo transfer, respectively. Analyses were by intention to treat. RESULTS: The implantation rate was significantly higher in the endometrial scratch group (41.3% [90/218]) than in the control group (30.0% [63/210]; P<0.001). The clinical pregnancy rate was also significantly higher in the endometrial scratch group (44.2% [61/138]) than in the control group (30.4% [41/135]; P<0.001). CONCLUSION: Endometrial injury in the cycle preceding the stimulation cycle improved implantation and pregnancy rates during ICSI. CLINICALTRIALS.GOV: NCT02660125.


Subject(s)
Embryo Implantation , Endometrium/injuries , Sperm Injections, Intracytoplasmic/methods , Adult , Egypt , Embryo Transfer/methods , Female , Follicle Stimulating Hormone/administration & dosage , Hormones/administration & dosage , Humans , Pregnancy , Pregnancy Rate
3.
Hypertens Pregnancy ; 35(1): 91-9, 2016.
Article in English | MEDLINE | ID: mdl-26909769

ABSTRACT

UNLABELLED: SYNOPSIS IV MgSO4 administration in women with severe preeclampsia resulted in a decrease in umbilical artery, uterine artery, and fetal middle cerebral artery Doppler indices. OBJECTIVE: To evaluate Doppler parameters of the umbilical artery (UmA), uterine artery (UA), and fetal middle cerebral artery (MCA) before and after MgSO4 administration in women with severe preeclampsia. METHODS: A case control study included 100 pregnant women with severe preeclampsia. Umbilical artery, uterine artery, and fetal middle cerebral artery Doppler were measured before and 20 minutes after intravenous administration of 6 g of magnesium sulfate. RESULTS: There was a significant difference between maternal systolic blood pressure (173.20 ± 22.72 vs. 156.60 ± 19.18), diastolic blood pressure (109.60 ± 9.14 vs. 101.90 ± 10.05), and heart rate (80.52 ± 11.52 vs. 88.48 ± 12.08) before and after administration of MgSO4 in the studied patients (p value < 0.001). There was a significant difference between umbilical artery, middle cerebral artery, and uterine artery Doppler parameters before and after administration of MgSO4 in the studied patients (p value < 0.001). There was no significant difference between umbilical artery/middle cerebral artery with regard to RI and PI. However, there was significant difference with regard to the S/D ratio (p value < 0.001). The decrease in the values of Doppler parameters before and after administration of MgSO4 was more in the middle cerebral artery than in the umbilical artery. CONCLUSION: Intravenous administration of magnesium sulfate in pregnant women with severe preeclampsia resulted in a decrease in umbilical artery, uterine artery, and fetal middle cerebral artery Doppler indices with reduced resistance to blood flow in these vessels.


Subject(s)
Magnesium Sulfate/pharmacology , Middle Cerebral Artery/drug effects , Pre-Eclampsia/drug therapy , Ultrasonography, Prenatal , Umbilical Arteries/drug effects , Uterine Artery/drug effects , Adolescent , Adult , Blood Pressure/drug effects , Case-Control Studies , Female , Humans , Magnesium Sulfate/therapeutic use , Middle Cerebral Artery/diagnostic imaging , Pre-Eclampsia/diagnostic imaging , Pregnancy , Pulsatile Flow/drug effects , Umbilical Arteries/diagnostic imaging , Uterine Artery/diagnostic imaging , Uterus/blood supply , Vascular Resistance/drug effects , Young Adult
4.
J Matern Fetal Neonatal Med ; 27(17): 1790-4, 2014 Nov.
Article in English | MEDLINE | ID: mdl-24433111

ABSTRACT

OBJECTIVE: To establish a nomogram of fetal urine production according to gestational age as a predictor for fetal well-being in normal and diabetic women. STUDY DESIGN: Prospective observational study included 180 pregnant women classified into two groups: Group I (120 women) without any medical complications and Group II (60 women) with gestational diabetes mellitus (GDM). The fetal bladder is measured by the virtual organ computer-aided analysis VOCAL 3D ultrasound scanner. RESULTS: There was a significant positive correlation between gestational age and fetal urine production rate (UPR) (the mean UPR rate in normal pregnancy at 25, 30, 35, 40 weeks were 12.3, 14.38, 56.13 and 90.73 ml/h, respectively). There was no significant difference regarding UPR ml/h between women with normal pregnancy and those with controlled GDM (p = 0.9). There was a statistically significant difference regarding UPR ml/h between women with normal pregnancy and those with uncontrolled GDM (p = 0.012) and a statistically significant difference between women with controlled GDM and those with uncontrolled GDM (p = 0.03). CONCLUSION: Fetal UPR is considered to be more reliable as an assessment method for fetal well-being and shows significant increase in patients with uncontrolled gestational DM.


Subject(s)
Diabetes, Gestational/diagnostic imaging , Fetus/physiology , Ultrasonography, Prenatal/methods , Urinary Bladder/diagnostic imaging , Urination/physiology , Adolescent , Adult , Diabetes, Gestational/physiopathology , Female , Gestational Age , Humans , Imaging, Three-Dimensional , Pregnancy , Prospective Studies , Urinary Bladder/embryology , Young Adult
5.
Int J Gynaecol Obstet ; 114(2): 145-8, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21669426

ABSTRACT

OBJECTIVES: To compare the adverse effects, cycle control, and metabolic effects of NuvaRing and a combined oral contraceptive (COC). METHODS: Women seeking contraception received NuvaRing (n = 300) or a COC (n = 300) for 12 cycles in a randomized, open-label trial. RESULTS: The total number of women with adverse effects did not differ significantly between the 2 groups. Leucorrhea, vaginitis, decreased libido, and ring-related problems were more common with NuvaRing, whereas weight increase, acne, and emotional lability were more common with the COC. Breakthrough bleeding occurred in 11.3% of women receiving NuvaRing and in 14.7% of women receiving the COC; 2.1% and 2.9% of women, respectively, had no withdrawal bleeding. Differences in blood pressure, blood sugar levels, lipid profile, liver enzyme activity, and anticoagulant activity were not statistically significant, with the exception of low-density lipoprotein levels measured at 6 and 12 months, which were significantly lower in the NuvaRing group than in the COC group. CONCLUSIONS: NuvaRing is a good alternative to a COC. It is associated with a slightly reduced incidence of breakthrough bleeding and there were no clinically relevant adverse effects or changes in blood pressure, blood sugar levels, lipid profile, or anticoagulant activity when compared with the COC.


Subject(s)
Androstenes/administration & dosage , Contraceptives, Oral, Combined/adverse effects , Contraceptives, Oral, Hormonal/administration & dosage , Ethinyl Estradiol/administration & dosage , Acne Vulgaris/chemically induced , Adolescent , Adult , Affective Symptoms/chemically induced , Androstenes/adverse effects , Contraceptive Devices, Female/adverse effects , Contraceptives, Oral, Combined/administration & dosage , Contraceptives, Oral, Hormonal/adverse effects , Desogestrel/administration & dosage , Desogestrel/adverse effects , Desogestrel/analogs & derivatives , Drug Combinations , Ethinyl Estradiol/adverse effects , Female , Humans , Leukorrhea/chemically induced , Libido/drug effects , Lipoproteins, LDL/blood , Metrorrhagia/chemically induced , Vaginitis/chemically induced , Weight Gain/drug effects , Young Adult
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