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Protein Pept Lett ; 17(6): 723-31, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20015023

ABSTRACT

tate-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimer's disease). This molecular farming approach led to highest protein production of hydroponically-grown tobacco compared to other growth substrates generally used in plant cultivation.


Subject(s)
Alzheimer Disease/prevention & control , Nicotiana/metabolism , Plant Proteins/metabolism , Plant Proteins/therapeutic use , Biomass , Biotechnology/methods , Hydroponics/methods , Nitrates/metabolism , Nitrogen/metabolism , Pharmaceutical Preparations/metabolism , Phosphates/metabolism , Plant Shoots/genetics , Plant Shoots/growth & development , Plant Shoots/metabolism , Plants, Genetically Modified , Quaternary Ammonium Compounds/metabolism , Technology, Pharmaceutical/methods , Time Factors , Nicotiana/genetics , Nicotiana/growth & development
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