Investigation of uncertainty in internal target volume definition for lung stereotactic body radiotherapy.

This study evaluated the validity of internal target volumes (ITVs) defined by three- (3DCT) and four-dimensional computed tomography (4DCT), and subsequently compared them with actual movements during treatment. Five patients with upper lobe lung tumors were treated with stereotactic body radiotherapy (SBRT) at 48 Gy in four fractions. Planning 3DCT images were acquired with peak-exhale and peak-inhale breath-holds, and 4DCT images were acquired in the cine mode under free breathing. Cine images were acquired using an electronic portal imaging device during irradiation. Tumor coverage was evaluated based on the manner in which the peak-to-peak breathing amplitude on the planning CT covered the range of tumor motion (± 3 SD) during irradiation in the left-right, anteroposterior, and cranio-caudal (CC) directions. The mean tumor coverage of the 4DCT-based ITV was better than that of the 3DCT-based ITV in the CC direction. The internal margin should be considered when setting the irradiation field for 4DCT. The proposed 4DCT-based ITV can be used as an efficient approach in free-breathing SBRT for upper-lobe tumors of the lung because its coverage is superior to that of 3DCT.

Dosimetric assessment of a single-energy metal artifact reduction algorithm for computed tomography images in radiation therapy.

This study aimed to evaluate the performance of a single-energy metal artifact reduction (SEMAR) algorithm for radiation therapy treatment using phantom cases with metal inserts, assess improvements in computed tomography (CT) number accuracy, and investigate its effects on treatment planning dosimetry. A standard electron density phantom was scanned with and without metal inserts. The numbers of tissue-equivalent materials on both uncorrected and SEMAR-corrected CT images were compared. Treatment planning accuracy was evaluated by comparing dose distributions computed using true density images (without metal inserts), uncorrected images (with metal inserts), and SEMAR-corrected images (with metal inserts) using three-dimensional gamma analysis. The numbers of the true density and uncorrected and SEMAR-corrected CT images in a muscle plug with unilateral inserts were 25.9 HU, - 281.8 HU, and 26.1 HU, respectively. A similar tendency was obtained for other tissue-equivalent materials, and the numbers on CT images were improved with the SEMAR algorithm. In cases involving 1 portal irradiation, 10-MV X-ray, and the Acuros XB algorithm, the pass ratio between the true density and uncorrected images was 89.89%, while that between the true density and SEMAR-corrected images was 95.03%. Improvements in dose distribution were evident using the SEMAR algorithm. Similar trends were found for different irradiation methods and dose calculation algorithms. The SEMAR algorithm can significantly reduce metal artifacts on CT images used for radiation treatment planning. This aspect influenced dosimetry in the region of the artifact and dose distribution was significantly improved with use of the SEMAR-corrected images.