ABSTRACT
Chromhidrosis is a rare disorder, which can have significant psychosocial consequences for patients, particularly when it affects the face, as it can be mistaken for scarring, dirt or erroneous make-up application. Chromhidrosis can be divided into apocrine, eccrine and pseudo subtypes. We present a case of apocrine chromhidrosis localized to the bilateral cheek area. Click https://www.wileyhealthlearning.com/#/online-courses/9c761d0a-20de-4709-a57d-36be93cf64e1 for the corresponding questions to this CME article.
Subject(s)
Facial Dermatoses/pathology , Pigmentation Disorders/pathology , Sweat Gland Diseases/pathology , Adult , Affect , Cheek/pathology , Dermoscopy , Facial Dermatoses/psychology , Female , Humans , Pigmentation Disorders/psychology , Sweat Gland Diseases/psychologySubject(s)
Adrenergic beta-Antagonists/therapeutic use , Angiokeratoma/drug therapy , Atenolol/therapeutic use , Skin Neoplasms/drug therapy , Timolol/therapeutic use , Abdomen/pathology , Administration, Oral , Administration, Topical , Angiokeratoma/pathology , Female , Humans , Skin Neoplasms/pathology , Young AdultSubject(s)
Exanthema/etiology , Purpura/etiology , Scurvy/complications , Humans , Male , Middle AgedSubject(s)
Dermatitis/diagnosis , Lymphedema/etiology , Obesity, Morbid/complications , Scleroderma, Localized/diagnosis , Abdomen/blood supply , Dermatitis/etiology , Dermatitis/pathology , Diagnosis, Differential , Humans , Male , Middle Aged , Scleroderma, Localized/etiology , Scleroderma, Localized/pathologySubject(s)
Dermatologic Agents/therapeutic use , Eosinophilia/drug therapy , Folliculitis/drug therapy , Methotrexate/therapeutic use , Skin Diseases, Vesiculobullous/drug therapy , Skin/pathology , Aged, 80 and over , Dermatitis, Exfoliative/pathology , Eosinophilia/complications , Folliculitis/complications , Humans , Male , Pruritus/drug therapy , Pruritus/etiology , Skin Diseases, Vesiculobullous/complicationsSubject(s)
Anti-Bacterial Agents/administration & dosage , Deglutition Disorders/complications , Deglutition , Dermatologic Agents/administration & dosage , Capsules , Cyclosporine/administration & dosage , Erythromycin/administration & dosage , Humans , Isotretinoin/administration & dosage , Lymecycline/administration & dosage , Methotrexate/administration & dosage , TabletsSubject(s)
Angiogenesis Inhibitors/therapeutic use , Dermatologic Agents/therapeutic use , Immunologic Factors/therapeutic use , Necrobiotic Xanthogranuloma/drug therapy , Thalidomide/analogs & derivatives , Aged , Female , Humans , Lenalidomide , Necrobiotic Xanthogranuloma/pathology , Thalidomide/therapeutic useSubject(s)
Dermatologic Agents/therapeutic use , Isotretinoin/therapeutic use , Peanut Hypersensitivity/drug therapy , Plant Oils/adverse effects , Adolescent , Adult , Contraindications , Dermatologic Agents/chemistry , Female , Humans , Isotretinoin/chemistry , Male , Peanut Hypersensitivity/prevention & control , Peanut Oil , United Kingdom , Young AdultABSTRACT
Familial multiple discoid fibromas is a rare genodermatosis that bears some resemblance to Birt-Hogg-Dubé syndrome but is not associated with mutations in the folliculin (FLCN) gene or systemic manifestations. It is characterized by the development of papules over the face and pinnae early in life. Histological findings are of fibrovascular tumours adjacent to hair follicles without features characteristic of fibrofolliculomas, which have recently been termed discoid fibromas. We present siblings with multiple papules over the face and pinnae that developed in childhood. Histological specimens from both siblings demonstrated discoid fibromas, but with some lesions exhibiting an unusual keloidal-like pattern with thick hyalinized collagen fibres surrounded by plump spindle and histiocyte-like cells. FLCN gene mutations were not found. We report on clinical improvement with topical rapamycin solution (1 mg mL(-1)) applied daily to the face for 4 months. Therapeutic response to topical rapamycin may provide a clue to the underlying genetic basis of this condition.