1.
Bioorg Med Chem Lett
; 16(21): 5691-4, 2006 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-16931005
ABSTRACT
The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.
Subject(s)
Adrenergic beta-3 Receptor Antagonists , Adrenergic beta-Agonists/pharmacology , Benzimidazoles/pharmacology , Adrenergic beta-Agonists/chemistry , Benzimidazoles/chemistry , Humans
2.
Bioorg Med Chem Lett
; 15(10): 2553-7, 2005 May 16.
Article
in English
| MEDLINE
| ID: mdl-15863315
ABSTRACT
Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.