ABSTRACT
Existence of subpolar tuberculoid leprosy was postulated by a few leprologists to explain clinical variations near the tuberculoid pole but failed to precisely identify the same. An attempt has been made to describe the clinical and histological features of subpolar tuberculoid leprosy. 76 cases of the TT-BT range according to Ridley-Jopling classification were examined by detailed clinical, histological and immunological methods. Definite clinical and histological discrepancies from either BT or TTp were seen in 30 (39.4%) cases, confirming the existence of subpolar tuberculoid leprosy (TTs) and thus clarifying the immunological spectrum of leprosy.
Subject(s)
Leprosy/diagnosis , Skin/pathology , Humans , Lepromin/immunology , Leprosy/pathologySubject(s)
Prolactin/blood , Thyrotropin-Releasing Hormone/pharmacology , Vitiligo/physiopathology , Female , Humans , MaleABSTRACT
Contrary to the unitarian concept of acrokeratosis verruciformis and Darier's disease, a comparative familial, clinical and histopathological analysis of six cases each of these two diseases has suggested that they are separate entities. Though clinically similar, acrokeratosis remained non-dyskeratotic throughout life, whereas the acral lesions of Darier's disease showed, on careful scrutiny and follow-up, various gradations of benign acantholytic dyskeratosis. Malignant transformation indicated that dyskeratosis in Hopf's disease would be very rare and of a different nature. The probability of a genetic linkage between the two genodermatoses is reviewed and discussed.