Subject(s)
Endocrine System Diseases/veterinary , Horse Diseases/physiopathology , Animals , Endocrine System Diseases/diagnosis , Endocrine System Diseases/physiopathology , Horse Diseases/diagnosis , Horses , Islets of Langerhans/physiopathology , Metabolic Syndrome/physiopathology , Metabolic Syndrome/veterinary , Pituitary Diseases/physiopathology , Pituitary Diseases/veterinary , Pituitary Gland, Intermediate/physiopathologyABSTRACT
BACKGROUND: Despite the increasing number of geriatric horses attended by veterinarians, there is a lack of understanding of aging-related changes on the respiratory system of horses. OBJECTIVE: To identify aging-related changes on the respiratory function and bronchoalveolar lavage fluid (BALF) cytology of horses. ANIMALS: Fifteen healthy young adult (2-11 years) and 16 healthy aged (≥20 years) horses. METHODS: The respiratory system was examined by measurement of arterial blood gases (ABG), use of respiratory inductive plethysmography (RIP) for assessment of breathing pattern and ventilatory parameters, histamine bronchoprovocation, and BALF cytology. RESULTS: No significant differences were detected with regard to values obtained by ABG or bronchoprovocation of young adult and aged healthy horses. In aged horses, there were significant differences in mean ± SD of the following parameters when compared to young horses: prolonged expiratory time (Te) measured by RIP (3.9 ± 1.5 s versus 3.0 ± 0.6 s), decreased percentage of alveolar macrophages (40.6 ± 11.3% versus 53.5 ± 9.6%), and increased percentage of lymphocytes (53.4 ± 9.5% versus 43.9 ± 11.0%). No correlations between airway reactivity and ventilatory parameters, ABG, or BALF cytology were found in this asymptomatic population. CONCLUSIONS: These results suggest that aging does not cause changes in the results obtained by ABG, most RIP-derived variables, and bronchoprovocation in the horse. A decreased percentage of macrophage and an increased percentage of lymphocytes in the BALF cytology may be expected in the asymptomatic geriatric horse and may be a result of aging.
Subject(s)
Bronchoalveolar Lavage Fluid/cytology , Horses/physiology , Aging/blood , Aging/physiology , Animals , Blood Gas Analysis/veterinary , Female , Horses/blood , Horses/growth & development , Male , Respiratory Physiological Phenomena , Spirometry/veterinaryABSTRACT
REASONS FOR PERFORMING STUDY: Methods that can be used to estimate rates of healthcare-associated infections and other nosocomial events have not been well established for use in equine hospitals. Traditional laboratory-based surveillance is expensive and cannot be applied in all of these settings. OBJECTIVES: To evaluate the use of a syndromic surveillance system for estimating rates of occurrence of healthcare-associated infections among hospitalised equine cases. STUDY DESIGN: Multicentre, prospective longitudinal study. METHODS: This study included weaned equids (n = 297) that were admitted for gastrointestinal disorders at one of 5 participating veterinary referral hospitals during a 12-week period in 2006. A survey form was completed by the primary clinician to summarise basic case information, procedures and treatments the horse received, and whether one or more of 7 predefined nosocomial syndromes were recognised at any point during hospitalisation. Adjusted rates of nosocomial events were estimated using Poisson regression. Risk factors associated with the risk of developing a nosocomial event were analysed using multivariable logistic regression. RESULTS: Among the study population, 95 nosocomial events were reported to have occurred in 65 horses. Controlling for differences among hospitals, 19.7% (95% confidence interval, 14.5-26.7) of the study population was reported to have had at least one nosocomial event recognised during hospitalisation. The most commonly reported nosocomial syndromes that were unrelated to the reason for hospitalisation were surgical site inflammation and i.v. catheter site inflammation. CONCLUSIONS: Syndromic surveillance systems can be standardised successfully for use across multiple hospitals without interfering with established organisational structures, in order to provide useful estimates of rates related to healthcare-associated infections.
Subject(s)
Cross Infection/veterinary , Horse Diseases/microbiology , Hospitals, Animal/standards , Animals , Cross Infection/epidemiology , Epidemiological Monitoring/veterinary , Horses , Longitudinal Studies , Risk Factors , United States/epidemiologyABSTRACT
BACKGROUND: Expected rates of healthcare-associated infections (HCAI) have not been established in veterinary hospitals. Baseline rates are critically needed as benchmarks for quality animal care. OBJECTIVE: To estimate the occurrence of events related to HCAI identified using a standardized syndromic surveillance system in small animals in critical care cases at referral hospitals. ANIMALS: Weaned dogs and cats (n = 1,951) that were hospitalized in the critical care unit of referral teaching hospitals during a 12-week period. METHODS: Multicenter, prospective longitudinal study. A survey was completed for all enrolled animals to record basic demographics, information about procedures and treatments that animals received, and to document the occurrence of defined nosocomial syndromes. Data were analyzed to identify risk factors associated with the occurrence of these nosocomial syndromes. RESULTS: Controlling for hospital of admission, 16.3% of dogs (95% confidence intervals [CI], 14.3-18.5) and 12% of cats (95% CI, 9.3-15.5) were reported to have had ≥ 1 nosocomial syndrome occur during hospitalization. Risk factors found to have a positive association with the development of a nosocomial syndrome were longer hospital stays, placement of a urinary catheter, surgical procedures being performed, and the administration of antiulcer medications and antimicrobial drugs excluding those given perioperatively. CONCLUSIONS AND CLINICAL IMPORTANCE: Syndromic surveillance systems can be successfully standardized for use across multiple hospitals to effectively collect data pertinent to HCAI rates and risk factors for occurrence.
Subject(s)
Cat Diseases/epidemiology , Cross Infection/veterinary , Dog Diseases/epidemiology , Epidemiological Monitoring/veterinary , Animals , Cats , Cross Infection/epidemiology , Dogs , Female , Hospitals, Animal , Intensive Care Units , Longitudinal Studies , Male , Prospective Studies , Risk FactorsABSTRACT
BACKGROUND: Plasma α-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropin (ACTH) concentrations in horses vary with season, confounding diagnostic testing for pituitary pars intermedia dysfunction (PPID). HYPOTHESIS: The goals of this study were to determine whether seasonal variation in plasma α-MSH and ACTH concentrations in horses is influenced by geographic location, breed, or PPID. ANIMALS: Healthy light breed horses residing in Florida, Massachusetts, and Finland (n = 12 per group); healthy Morgan horses (n = 13); healthy ponies (n = 9) and horses with PPID (n = 8). METHODS: Monthly plasma α-MSH and ACTH concentrations were measured by radioimmunoassay. Nonlinear regression analysis was used to estimate the time of peak hormone concentrations. Mean hormone concentrations in fall and nonfall months were compared. RESULTS: The fall peak plasma α-MSH concentration occurred earlier in horses residing at more northern locations. Mean seasonal α-MSH concentrations were similar in all healthy groups at all locations, but in the fall, plasma ACTH concentrations were higher in horses living in more southern locations. Plasma ACTH but not α-MSH concentrations were higher in Morgan horses compared with light breed horses from the same location. Hormone concentrations of ponies did not differ from those of horses during either season. Concentrations of both hormones were high in the fall compared with the spring in horses with PPID. CONCLUSIONS AND CLINICAL IMPORTANCE: These findings suggest geographic location of residence and breed may affect the onset, amplitude, or both of the seasonal peak of pars intermedia (PI) hormones and should be considered when performing diagnostic testing for PPID. Horses with PPID maintain seasonal regulation of PI hormone output.
Subject(s)
Adrenocorticotropic Hormone/blood , Horses/blood , Pituitary Gland, Intermediate/physiopathology , alpha-MSH/blood , Animals , Female , Finland , Florida , Male , Massachusetts , Regression Analysis , SeasonsSubject(s)
Anti-Bacterial Agents/pharmacokinetics , Aztreonam/pharmacokinetics , Horses/metabolism , Animals , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/blood , Area Under Curve , Aztreonam/administration & dosage , Aztreonam/blood , Half-Life , Horses/blood , Injections, IntravenousABSTRACT
The medical records of 163 neonatal foals that had thoracic radiographs taken within 48 hours of admission to a referral hospital were reviewed. The objectives of this study were (1) to identify risk factors for the development of thoracic radiographic changes and (2) to identify prognostic indicators for survival in foals with radiographic evidence of pulmonary disease. Failure of transfer of passive immunity (IgG concentration < or = 400 mg/dL) was the only risk factor for radiographic evidence of respiratory disease identified by multivariate analysis. Hypoxemic patients (PaO2 < or = 60 mm Hg) were 4.9 times more likely to reveal radiographic abnormalities in a subset of foals for which arterial blood gas results were available. Foals with a serum creatinine concentration > 1.7 mg/dL upon presentation, dyspnea, and a history of dystocia were significantly more likely to die based on the multivariate statistical outcome analysis. An anion gap > or = 20 mEq/dL was strongly associated with nonsurvival in a subset of foals with arterial blood gas results. These hematologic and biochemical variables can be readily obtained during the initial evaluation of sick foals. The presence of a high anion gap appeared to have the greatest clinical impact and may be a useful prognostic indicator in foals with radiographic evidence of respiratory disease. In contrast, the majority of physical examination variables, including evaluation of tachypnea, abnormal respiratory sounds, fever, weakness, and milk reflux from the nares, which are usually obtained during the general respiratory evaluation of foals, were unrelated to outcome.
Subject(s)
Horse Diseases/diagnostic imaging , Lung Diseases/veterinary , Radiography, Thoracic/veterinary , Acid-Base Equilibrium/physiology , Animals , Animals, Newborn , Blood Cell Count/veterinary , Blood Chemical Analysis/veterinary , Blood Gas Analysis/veterinary , Cohort Studies , Horses , Logistic Models , Lung Diseases/diagnostic imaging , Multivariate Analysis , Predictive Value of Tests , Retrospective Studies , Risk FactorsABSTRACT
A total of 207 thoracic radiographs obtained from 128 foals were evaluated to assess the impact of pulmonary radiographic pattern, distribution, and severity of pulmonary changes on short-term survival of neonatal foals. The association between selected clinical variables and the radiographic manifestation of neonatal respiratory disease was also investigated. The evaluation of interstitial and alveolar-interstitial radiographic patterns within the caudodorsal, caudoventral, and cranioventral lung regions proved to be highly reliable between viewers in the study. A diagnosis of systemic inflammatory response syndrome was related to increased pulmonary infiltrates within the caudodorsal lung region. Dyspneic foals had more extensive pulmonary infiltrates within the cranioventral lung, advanced respiratory disease, and lower survival rates. A fibrinogen concentration >400 mg/dL was associated with increased cranioventral radiographic abnormalities. In addition, tachypnea most consistently related to diffuse (caudodorsal, caudoventral, and cranioventral) pulmonary changes. Neutropenia, milk reflux from the nares, upper airway pathology, abnormal respiratory sounds, failure of transfer of passive immunity (IgG concentration <400 mg/dL), immaturity, or fever, however, were not related to radiographic pattern, distribution, or severity of radiographic changes. Sixty-five percent of foals with radiographic pulmonary disease were discharged alive from our referral hospital. Concurrent caudodorsal and caudoventral radiographic disease was most frequently observed in this foal population. Increased caudodorsal radiographic scores retained statistical significance as a prognostic indicator for nonsurvival in a multiple stepwise logistic regression analysis.
Subject(s)
Horse Diseases/diagnostic imaging , Lung Diseases/diagnostic imaging , Lung Diseases/veterinary , Radiography, Thoracic/veterinary , Animals , Animals, Newborn , Cohort Studies , Horses , Logistic Models , Observer Variation , Predictive Value of Tests , Radiography, Thoracic/methods , Radiography, Thoracic/standards , Retrospective StudiesABSTRACT
Twenty-eight horses with the diagnosis of an intestinal disorder requiring surgical intervention were randomly assigned to lidocaine (n = 13) or saline (control, n = 15) treatment groups. After induction of anesthesia, treated horses received a loading dose of 2% lidocaine (0.65 mg/kg) intravenously, followed by a continuous rate of infusion of 1% lidocaine (0.025 mg/kg/min) until the discontinuation of anesthesia. Upon recovery from anesthesia, a 2nd loading dose of 2% lidocaine (1.3 mg/kg) was administered, followed by an infusion of 1% lidocaine (0.05 mg/kg/min) for 24 hours postoperatively. The control group received equivalent volumes of saline. Lidocaine-treated horses had significantly better minimum jejunal cross-sectional area scores (P = .011), minimum jejunal diameter scores (P = .002), and intestinal ultrasound index (IUI) (P = .007). Peritoneal fluid was detected by percutaneous ultrasound examination in 8 of the 15 control animals but in none of the treated animals (P = .003). Failure to obtain fluid via abdominocentesis was significantly more frequent for lidocaine-treated horses (P = .025). No significant differences between the groups were found in the presence of gastrointestinal sounds, time to passage of 1st feces, number of defecations in the 1st 24 hours, presence of gastric reflux, duodenal or jejunal wall thickness, maximum duodenal or jejunal diameter or cross-sectional area, minimum duodenal diameter or cross-sectional area, duodenal and jejunal intraluminal echogenicity, small-intestinal contractions per minute, rate of complications, or outcome. On the basis of this study, lidocaine infusion may have some desirable effects on jejunal distension and peritoneal fluid accumulation and was well tolerated perioperatively in horses with colic. The low incidence of small-intestinal lesions and gastric reflux in the study makes it difficult to assess the use of lidocaine in the prevention of postoperative ileus (POI).
Subject(s)
Anesthetics, Local/pharmacology , Colic/veterinary , Horse Diseases/surgery , Lidocaine/pharmacology , Postoperative Complications/veterinary , Abdominal Pain/etiology , Abdominal Pain/veterinary , Anesthesia, General/veterinary , Anesthetics, Local/administration & dosage , Animals , Ascitic Fluid , Colic/surgery , Female , Gastrointestinal Motility , Horses , Infusions, Intravenous , Jejunum/anatomy & histology , Jejunum/pathology , Lidocaine/administration & dosage , MaleABSTRACT
OBJECTIVE: To determine the complementary DNA (cDNA) sequence of interleukin-1 receptor antagonist (IL-1ra) in horses and compare messenger RNA (mRNA) expression of IL-1ra among horses of various breeds. SAMPLE POPULATION: Blood samples from neonatal and adult horses examined for a variety of diseases. PROCEDURE: A polymerase chain reaction procedure was used to amplify a 220 base pair (bp) portion of the genomic DNA. The upstream and downstream regions of the cDNA sequence were determined by means of 5' and 3' rapid amplification of cDNA ends (RACE) procedures. Northern blot hybridization was used to examine steady-state mRNA expression of IL-1ra. RESULTS: The consensus sequence of the cDNA obtained with the 5'-RACE procedure and the sequence for the 220 bp portion of the genomic DNA represented the putative sequence for secreted IL-1ra. The predicted secreted IL-1ra amino acid sequence contained 176 residues with an in-frame stop codon; the N-terminal 25 amino acid residues resembled the signal peptide reported for human secreted IL-1ra. An approximately 1.3 kilobase pair (kb) band that represented a portion of the 3' end of the coding region and the 3' untranslated region was obtained by use of the 3' -RACE procedure. Northern blot hybridization detected a 1.6 kb transcript in blood RNA from adult Arabian, Belgian, Thoroughbred, and Standardbred horses. CONCLUSIONS: Results suggest that the DNA for equine secreted IL-1ra has a short (29 bp) 5' untranslated region, a 534 bp coding region, and a long (approximately 1,080 bp) untranslated region.
Subject(s)
Antirheumatic Agents/chemistry , Gene Expression Regulation , Horse Diseases/immunology , Sialoglycoproteins/genetics , Amino Acid Sequence , Animals , Animals, Newborn , Base Sequence , Blotting, Northern/veterinary , DNA Primers/chemistry , DNA, Complementary/chemistry , DNA, Complementary/isolation & purification , Female , Horse Diseases/blood , Horses , Interleukin 1 Receptor Antagonist Protein , Molecular Sequence Data , Nucleic Acid Amplification Techniques/veterinary , RNA, Messenger/isolation & purification , RNA, Messenger/metabolism , Reverse Transcriptase Polymerase Chain Reaction/veterinary , Sequence Analysis, DNA , Sialoglycoproteins/chemistrySubject(s)
Carcinosarcoma/veterinary , Endometrial Neoplasms/veterinary , Swine Diseases/diagnosis , Animals , Blood Cell Count/veterinary , Blood Chemical Analysis/veterinary , Carcinosarcoma/diagnosis , Carcinosarcoma/pathology , Carcinosarcoma/secondary , Endometrial Neoplasms/diagnosis , Endometrial Neoplasms/pathology , Fatal Outcome , Female , Immunohistochemistry , Lung Neoplasms/secondary , Lung Neoplasms/veterinary , Lymph Nodes/pathology , Swine , Swine Diseases/pathology , Weight LossABSTRACT
OBJECTIVE: To determine whether physical examination, laboratory, or radiographic abnormalities in foals with Rhodococcus equi infection were associated with survival, ability to race at least once after recovery, or, for foals that survived and went on to race, subsequent racing performance. DESIGN: Retrospective study. ANIMALS: 49 Thoroughbreds and 66 Standardbreds admitted to 1 of 6 veterinary teaching hospitals between 1984 and 1992 in which R equi infection was positively diagnosed. PROCEDURE: Results of physical examination, laboratory testing, and thoracic radiography were reviewed. Indices of racing performance were obtained for foals that recovered and eventually raced and compared with values for the US racing population. RESULTS: 83 (72%) foals survived. Foals that did not survive were more likely to have extreme tachycardia (heart rate > 100 beats/min), be in respiratory distress, and have severe radiographic abnormalities on thoracic radiographs at the time of initial examination than were foals that survived. Clinicopathologic abnormalities were not associated with whether foals did or did not survive. Forty-five of the 83 surviving foals (54%) eventually raced at least once, but none of the factors examined was associated with whether foals went on to race. Racing performance of foals that raced as adults was not significantly different from that of the US racing population. CLINICAL IMPLICATIONS: R equi infection in foals is associated with a decreased chance of racing as an adult; however, foals that eventually go on to race perform comparably to the US racing population.
Subject(s)
Actinomycetales Infections/veterinary , Horse Diseases/physiopathology , Lung/diagnostic imaging , Pneumonia, Bacterial/veterinary , Rhodococcus equi , Actinomycetales Infections/diagnostic imaging , Actinomycetales Infections/physiopathology , Animals , Confidence Intervals , Female , Heart Rate/physiology , Horse Diseases/diagnostic imaging , Horse Diseases/mortality , Horses , Logistic Models , Male , Odds Ratio , Physical Examination/veterinary , Pneumonia, Bacterial/diagnostic imaging , Pneumonia, Bacterial/physiopathology , Radiography , Respiratory Insufficiency/microbiology , Respiratory Insufficiency/mortality , Respiratory Insufficiency/veterinary , Retrospective Studies , Risk Factors , Running/physiology , Tachycardia/microbiology , Tachycardia/mortality , Tachycardia/veterinary , Treatment OutcomeABSTRACT
Neoplasia of the central nervous system (CNS) can be divided into two main categories: nonpituitary CNS neoplasia and pituitary adenomas. Nonpituitary CNS neoplasias are generally compressive in nature, although some are also invasive. The majority of reported CNS tumors are secondary with only a few originating from nervous tissue. Pituitary adenomas predominantly occur in the pars intermedia of the older horse. Clinical signs, diagnostic testing, and possible treatments are discussed.
Subject(s)
Adenoma/veterinary , Central Nervous System Neoplasms/veterinary , Horse Diseases , Pituitary Neoplasms/veterinary , Adenoma/diagnosis , Adenoma/therapy , Animals , Horse Diseases/diagnosis , Horse Diseases/therapy , Horses , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/therapyABSTRACT
OBJECTIVE: To compare the efficacy of positive pressure ventilation applied through a mask versus an endotracheal tube, using anesthetized/paralyzed foals as a model for foals with hypoventilation. ANIMALS: Six 1-month-old foals. PROCEDURE: A crossover design was used to compare the physiologic response of foals to 2 ventilatory techniques, noninvasive mask mechanical ventilation (NIMV) versus endotracheal mechanical ventilation (ETMV), during a single period of anesthesia and paralysis. Arterial pH, PaO2, PaCO2, oxygen saturation, end-tidal CO2 tension, airway pressures, total respiratory system resistance, resistance across the upper airways (proximal to the midtracheal region), and positive end-expiratory pressures (PEEP) were measured. Only tidal volume (VT; 10, 12.5, and 15 ml/kg of body weight) or PEEP (7 cm of H2O) varied. RESULTS: Compared with ETMV, use of NIMV at equivalent VT resulted in PaCO2 and pH values that were significantly higher, but PaO2 was only slightly lower. Between the 2 methods, peak airway pressure was similar, but peak expiratory flow was significantly lower and total respiratory resistance higher at each VT for NIMV. Delivery of PEEP (7 cm of H2O) was slightly better for ETMV (7.1 +/- 1.3 cm of H2O) than for NIMV (5.6 +/- 0.6 cm of H2O). CONCLUSION: These data suggest that use of NIMV induces similar physiologic effects as ETMV, but the nasal cavities and mask contribute greater dead space, manifesting in hypercapnia. Increasing the VT used on a per kilogram of body weight basis, or the use of pressure-cycled ventilation might reduce hypercapnia during NIMV. CLINICAL RELEVANCE: Use of NIMV might be applicable in selected foals, such as those with hypoventilation and minimal changes in lung compliance, during weaning from endotracheal mechanical ventilation, or for short-term ventilation in weak foals.
Subject(s)
Airway Resistance/physiology , Horses/physiology , Oxygen Consumption/physiology , Pulmonary Ventilation/physiology , Respiration, Artificial/veterinary , Respiratory Physiological Phenomena , Aging/physiology , Animals , Blood Gas Analysis/methods , Blood Gas Analysis/veterinary , Body Weight/physiology , Cross-Over Studies , Horse Diseases/physiopathology , Hydrogen-Ion Concentration , Hypercapnia/physiopathology , Hypercapnia/veterinary , Hypoventilation/physiopathology , Hypoventilation/veterinary , Lung Compliance/physiology , Models, Biological , Positive-Pressure Respiration , Respiration, Artificial/methods , Tidal Volume/physiologyABSTRACT
Following parturition, a female llama was admitted to our hospital with a tear in the dorsal area of the vagina and peritonitis. The llama was clinically normal for 7 days after which its condition started to deteriorate, and the llama died 11 days after admission. On necropsy examination, the intact placenta was found in the abdominal cavity. Therefore, we suggest that in llamas with vaginal tears after parturition, it may be useful to immediately secure the fetal membranes with umbilical tape to the outside of the llama to ensure that the placenta will pass through the vulva. Additionally, in llamas with uterine or vaginal tears in which a retained placenta is suspected but cannot be identified in the uterus, exploratory laparotomy should be performed immediately, even if the llama appears clinically normal.
Subject(s)
Camelids, New World , Peritonitis/veterinary , Placenta, Retained/veterinary , Uterine Rupture/veterinary , Vagina/injuries , Animals , Dystocia/complications , Dystocia/veterinary , Female , Peritonitis/etiology , Placenta, Retained/complications , Pregnancy , Rupture/veterinary , Uterine Rupture/complicationsABSTRACT
Pituitary adenomas are commonly reported in older horses. The typical clinical signs associated with this condition, also known as equine Cushing's disease (ECD), are related to increased adrenocorticotropin (ACTH) production resulting in hyperadrenocorticism. The primary purpose of this study was to determine whether plasma ACTH concentrations differed between cushingoid and healthy horses. The second objective was to determine the effects of blood sample handling techniques on ACTH concentrations. A commercial human ACTH radioimmunoassay (RIA) was used to quantify equine plasma ACTH. Intra-assay and interassay variations, as well as dilutional parallelism were determined during the RIA validation. Plasma ACTH concentrations were evaluated in a group of healthy equids composed of 18 horses and 9 ponies, and in 22 equids with a clinical diagnosis of hyperadrenocorticism (11 horses and 11 ponies). The mean plasma ACTH concentrations in healthy horses and ponies, (18.68 +/- 6.79 pg/mL (mean +/- SD) and 8.35 +/- 2.92 pg/mL, respectively), were significantly different (P = .009). The mean plasma ACTH concentration in horses and ponies with ECD, (199.18 +/- 182.82 pg/mL and 206.21 +/- 319.56 pg/mL, respectively), were significantly higher than the mean ACTH concentration in the control animals (P < .001). Plasma ACTH concentrations appeared to be a sensitive and specific indicator of ECD in horses and ponies. ACTH concentrations measured in plasma samples kept at room temperature (19 degrees C) as long as 3 hours after blood collection were not statistically different from those of samples kept at 1 degree C.
Subject(s)
Adrenal Cortex Diseases/veterinary , Adrenocortical Hyperfunction/veterinary , Adrenocorticotropic Hormone/blood , Horse Diseases/blood , Horses/blood , Adrenal Cortex Diseases/blood , Adrenocortical Hyperfunction/blood , Adrenocortical Hyperfunction/diagnosis , Animals , Female , Male , Radioimmunoassay/veterinaryABSTRACT
Septicemia is the second most commonly diagnosed problem in the equine neonate, superseded only by the problem of inadequate transfer of maternal antibodies. This article reviews the factors that may put a foal at high risk for developing sepsis, the diagnostic tools used to identify these animals, some of the sequelae of sepsis, and the therapeutic modalities available to the clinician.
Subject(s)
Horse Diseases , Sepsis/veterinary , Animals , Animals, Newborn , Horse Diseases/diagnosis , Horse Diseases/etiology , Horse Diseases/therapy , Horses , Risk Factors , Sepsis/diagnosis , Sepsis/etiology , Sepsis/therapySubject(s)
Cryptococcosis/veterinary , Dermatomycoses/veterinary , Granuloma/veterinary , Horse Diseases , Animals , Biopsy/veterinary , Cryptococcosis/drug therapy , Cryptococcosis/pathology , Cryptococcosis/surgery , Debridement/veterinary , Dermatomycoses/drug therapy , Dermatomycoses/pathology , Dermatomycoses/surgery , Granuloma/drug therapy , Granuloma/pathology , Granuloma/surgery , Horse Diseases/drug therapy , Horse Diseases/pathology , Horse Diseases/surgery , Horses , Male , PrognosisABSTRACT
Six horses with chronic obstructive pulmonary disease (COPD) and 8 horses with recurrent urticaria were skin tested with 67 extracts from 58 allergens, including pollens, epidermals, cultivated farm plants, dusts, molds, and insects. Reactions were evaluated 3 times over a 24-hour period immediately after the injections. Results were compared with those obtained from 11 clinically normal horses. All horses had positive skin test reactions. Significant differences was evident between horses with COPD and clinically normal horses for only 3.0% of the possible extract reactions, and between horses with urticaria and clinically normal horses for only 4.5% of the possible extract reactions. Horses with COPD or urticaria had greater total percentage of allergen extract reactions than did clinically normal horses. Positive reactions were observed at all 3 evaluation periods, and late-onset reactions were not always preceded by positive reaction at earlier periods. All horses with COPD or urticaria had at least 1 skin test reaction that exceeded the mean +/- 2 SD, as calculated for each of the 67 extracts for the group of clinically normal horses.