ABSTRACT
AIM: The study aim was to evaluate the efficacy and safety of initial combination therapy with saxagliptin + metformin vs. saxagliptin or metformin monotherapy in treatment-naïve patients with type 2 diabetes (T2D) and inadequate glycaemic control. METHODS: In this multicentre, randomized, double-blind, active-controlled phase 3 trial, 1306 treatment-naïve patients with T2D >or=18 to Subject(s)
Adamantane/analogs & derivatives
, Diabetes Mellitus, Type 2/drug therapy
, Dipeptides/therapeutic use
, Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
, Hypoglycemic Agents/therapeutic use
, Metformin/therapeutic use
, Adamantane/administration & dosage
, Adamantane/therapeutic use
, Adult
, Blood Glucose
, Dipeptides/administration & dosage
, Dipeptidyl-Peptidase IV Inhibitors/administration & dosage
, Double-Blind Method
, Drug Therapy, Combination/methods
, Fasting
, Female
, Glycated Hemoglobin/metabolism
, Humans
, Hypoglycemic Agents/administration & dosage
, Male
, Metformin/administration & dosage
, Middle Aged
, Postprandial Period
, Treatment Outcome