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1.
Public Health ; 223: 179-182, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37666182

ABSTRACT

OBJECTIVES: To address existing inequalities, the Barcelona City Council launched a Neighbourhood Plan in 2016-2020. During the first wave of the COVID-19 pandemic, the Neighbourhood Plan interventions were intensified. This study aimed to assess the effect of the plan on the incidence of COVID-19 during the first wave of the pandemic in Barcelona. STUDY DESIGN: We used a quasi-experimental design with 16 intervention neighbourhoods and 17 neighbourhoods in the comparison group with similar socioeconomic characteristics. METHODS: We calculated the cumulative incidence rate (CIR) of COVID-19 per 100,000 inhabitants by sex, age groups, and neighbourhood of residence. Poisson regression models were fitted to estimate the crude relative risk and relative risk adjusted by socioeconomic status (cRR and aRR) and their 95% confidence intervals (CIs). RESULTS: The CIR of COVID-19 was lower in the intervention neighbourhoods (CIR: 841 per 100,000 inhabitants) than in the comparison group (CIR: 973 per 100,000 inhabitants). On multivariate analysis, the aRR was 0.77 (CI: 0.70-0.83) for men and 0.89 (CI: 0.83-0.96) for women. Among men older than 75 years (aRR = 0.73; CI: 0.62-0.86), statistically significant differences were found in the intervention neighbourhoods compared to the comparison group. This pattern was not observed in women older than 75 years (aRR = 1.13; CI: 0.99-1.30). CONCLUSION: This research finds positive short-term effect in the intervention neighbourhoods. We conclude that the COVID-19 control and prevention interventions are likely to explain the better performance in the neighbourhoods included in the Neighbourhood Plan.


Subject(s)
COVID-19 , Urban Renewal , Male , Humans , Female , Pandemics/prevention & control , COVID-19/epidemiology , COVID-19/prevention & control , Multivariate Analysis , Research Design
2.
J Sci Food Agric ; 102(14): 6397-6403, 2022 Nov.
Article in English | MEDLINE | ID: mdl-35553436

ABSTRACT

BACKGROUND: New consumer habits are forcing the food industry to develop new and healthy products. In response to this tendency, in this investigation, we obtained nanoemulgels by microfluidization containing inulin fibre and omega-3 fatty acids. First, the influence of the number of microfluidization cycles on the physical properties of the nanoemulsions was studied. Subsequently, an advanced-performance xanthan gum was added to the nanoemulsion in different nanoemulsion/xanthan ratios (1:1, 2:1, 3:1, 4:1, 1:2, and 1:3). RESULTS: Laser diffraction, multiple light scattering, and rheology techniques were used to characterize nanoemulsions and the corresponding nanoemulgels. The nanoemulsion with the lowest Sauter mean diameter (138 nm) and the longest physical stability was obtained after three passes through a microfluidization device at a fixed pressure of 103 421 kPa. Thus, these processing conditions were always used to obtain the nanoemulsion; these were subsequently mixed with a xanthan gum solution to produce nanoemulgels that showed weak gel-like viscoelastic and shear-thinning flow behaviours. A decrease in the nanoemulsion/xanthan ratio (i.e. by an increase in the content of xanthan gum in the nanoemulgel) increased the viscoelastic moduli and the zero shear viscosity values. A rise in the droplet size was observed with aging time, probably due to flocculation. The nanoemulsion/xanthan gum mass ratio of 1:3 yielded the most stable nanoemulgel. CONCLUSIONS: This work is a contribution to the development of functional foods. It has been demonstrated that it is possible to obtain a stable nanoemulgel-based food matrix containing fibre and omega-3 fatty acids. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.


Subject(s)
Fatty Acids, Omega-3 , Inulin , Emulsions/chemistry , Polysaccharides, Bacterial/chemistry , Rheology , Viscosity
3.
Neurología (Barc., Ed. impr.) ; 37(1): 1-12, Jan.-Feb. 2022. tab
Article in English, Spanish | IBECS | ID: ibc-204457

ABSTRACT

Introducción: La cefalea es uno de los motivos de consulta más comunes en neurología, siendo más frecuente durante la edad reproductiva. Por ello, es habitual encontrar en nuestras consultas pacientes embarazadas o en periodo de lactancia con dicha queja. Es importante conocer las opciones farmacológicas más seguras, cuáles no se deben emplear, así como cuándo sospechar cefaleas secundarias. Por este motivo, el Grupo de Estudio de Cefaleas de la Sociedad Española de Neurología ha elaborado una guía con las recomendaciones consensuadas acerca de los algoritmos diagnósticos y terapéuticos que se deben emplear durante el embarazo y la lactancia. Desarrollo: Esta guía ha sido redactada por un grupo de jóvenes neurólogos con especial interés y experiencia en cefaleas en colaboración con la Junta Directiva del Grupo de Estudio de Cefaleas de la Sociedad Española de Neurología. Las recomendaciones se centran en los fármacos aconsejados en las cefaleas primarias más frecuentes, tanto en su fase aguda como preventiva. En una segunda parte se aborda cuándo sospechar y qué pruebas realizar ante una posible cefalea secundaria durante el embarazo y la lactancia. Conclusiones: Esperamos que esta guía resulte de utilidad y permita su aplicación práctica en la consulta diaria. Asimismo, que sirva para actualizar y mejorar el conocimiento del manejo de las cefaleas durante estas etapas, para actuar con mayor confianza ante estas pacientes. (AU)


Introduction: Headache is one of the most common neurological complaints, and is most frequent during reproductive age. As a result, we are routinely faced with pregnant or breastfeeding women with this symptom in clinical practice. It is important to know which pharmacological choices are the safest, which should not be used, and when we should suspect secondary headache. To this end, the Spanish Society of Neurology's Headache Study Grouphas prepared a series of consensus recommendations on the diagnostic and therapeutic algorithms that should be followed during pregnancy and breastfeeding. Development: This guide was prepared by a group of young neurologists with special interest and experience in headache, in collaboration with the Group's Executive Committee. Recommendations focus on which drugs should be used for the most frequent primary headaches, both during the acute phase and for prevention. The second part addresses when secondary headache should be suspected and which diagnostic tests should be performed in the event of possible secondary headache during pregnancy and breastfeeding. Conclusions: We hope this guide will be practical and useful in daily clinical practice and that it will help update and improve understanding of headache management during pregnancy and breastfeeding, enabling physicians to more confidently treat these patients. (AU)


Subject(s)
Humans , Female , Pregnancy , Adult , Middle Aged , Breast Feeding , Pregnancy , Headache/diagnosis , Headache/therapy , Neurology , Migraine Disorders/diagnosis , Migraine Disorders/therapy , Congenital Abnormalities , Practice Guidelines as Topic
4.
Neurologia (Engl Ed) ; 37(1): 1-12, 2022.
Article in English | MEDLINE | ID: mdl-34535428

ABSTRACT

INTRODUCTION: Headache is one of the most common neurological complaints, and is most frequent during reproductive age. As a result, we are routinely faced with pregnant or breastfeeding women with this symptom in clinical practice. It is important to know which pharmacological choices are the safest, which should not be used, and when we should suspect secondary headache. To this end, the Spanish Society of Neurology's Headache Study Group has prepared a series of consensus recommendations on the diagnostic and therapeutic algorithms that should be followed during pregnancy and breastfeeding. DEVELOPMENT: This guide was prepared by a group of young neurologists with special interest and experience in headache, in collaboration with the Group's Executive Committee. Recommendations focus on which drugs should be used for the most frequent primary headaches, both during the acute phase and for prevention. The second part addresses when secondary headache should be suspected and which diagnostic tests should be performed in the event of possible secondary headache during pregnancy and breastfeeding. CONCLUSIONS: We hope this guide will be practical and useful in daily clinical practice and that it will help update and improve understanding of headache management during pregnancy and breastfeeding, enabling physicians to more confidently treat these patients.


Subject(s)
Breast Feeding , Neurology , Female , Headache/diagnosis , Headache/drug therapy , Humans , Pregnancy , Societies
5.
J Sci Food Agric ; 100(10): 3886-3894, 2020 Aug.
Article in English | MEDLINE | ID: mdl-32323323

ABSTRACT

BACKGROUND: Nowadays, it is of great interest to develop stable and sustainable formulations that act as nanocarriers of active ingredients. In this work, the droplet size distribution, rheology and physical stability of nanoemulsions with improved properties containing rosemary essential oil and biopolymers as a function of the concentration of these polysaccharides were investigated. RESULTS: Mean diameters below 150 nm were achieved, indicating nanostructures were obtained. Regardless of gum type, a gel-like structure and a shear thinning behaviour was achieved. In addition, an increase of G', G″ and viscosity and a decrease of J0 , J1 , J2 , λ1 and λ2 with increasing gum concentration were observed, due to the formation of a three-dimensional network in the aqueous phase. Slight differences between nanoemulsions containing welan or xanthan were found. Creaming, depletion flocculation and gel aggregation were the main destabilization processes at low, intermediate and high gum concentration, respectively. A 0.4 wt% gum nanoemulsion exhibited the best physical stability. CONCLUSION: These stable and sustainable nanoemulsions with improved rheological properties contribute to the development of biodegradable and non-toxic food or agrochemical products. © 2020 Society of Chemical Industry.


Subject(s)
Biopolymers/chemistry , Nanostructures/chemistry , Oils, Volatile/chemistry , Rosmarinus/chemistry , Emulsions/chemistry , Polysaccharides, Bacterial/analysis , Rheology , Viscosity
6.
J Proteomics ; 221: 103757, 2020 06 15.
Article in English | MEDLINE | ID: mdl-32247173

ABSTRACT

Atherosclerosis remains the leading cause of ischemic syndromes such as myocardial infarction or brain stroke, mainly promoted by plaque rupture and subsequent arterial blockade. Identification of vulnerable or high-risk plaques constitutes a major challenge, being necessary to identify patients at risk of occlusive events in order to provide them with appropriate therapies. Clinical imaging tools have allowed the identification of certain structural indicators of prone-rupture plaques, including a necrotic lipidic core, intimal and adventitial inflammation, extracellular matrix dysregulation, and smooth muscle cell depletion and micro-calcification. Additionally, alternative approaches focused on identifying molecular biomarkers of atherosclerosis have also been applied. Among them, proteomics has provided numerous protein markers currently investigated in clinical practice. In this regard, it is quite uncertain that a single molecule can describe plaque rupture, due to the complexity of the process itself. Therefore, it should be more accurate to consider a set of markers to define plaques at risk. Herein, we propose a selection of 76 proteins, from classical inflammatory to recently related markers, all of them identified in at least two proteomic studies analyzing unstable atherosclerotic plaques. Such panel could be used as a prognostic signature of plaque instability.


Subject(s)
Atherosclerosis , Plaque, Atherosclerotic , Biomarkers , Humans , Inflammation , Proteomics
7.
Neurología (Barc., Ed. impr.) ; 35(3): 176-184, abr. 2020. tab, graf
Article in Spanish | IBECS | ID: ibc-197530

ABSTRACT

INTRODUCCIÓN: Cuando tras una correcta anamnesis y exploración neurológica se diagnostica a un paciente con una cefalea primaria o una neuralgia craneofacial en urgencias o atención primaria y se decide derivar a neurología por complejidad es útil conocer si además se deberían solicitar exploraciones complementarias y la preferencia (urgente, preferente o normal) con la que se debería derivar para que el paciente llegue a la consulta del neurólogo sin demoras innecesarias en pacientes con dolores incapacitantes o con sospecha de organicidad. Por este motivo, el Grupo de Estudio de Cefalea de la Sociedad Española de Neurología, ha decidido crear unas recomendaciones consensuadas que establezcan un protocolo de derivación de pacientes con cefalea y/o neuralgias craneofaciales. DESARROLLO: Se ha contactado con neurólogos jóvenes con interés y experiencia en cefalea y con la Junta Directiva del Grupo de Estudio de Cefalea de la Sociedad Española de Neurología que han desarrollado este documento que, por razones prácticas, se ha dividido en 2 artículos. Esta primera centrada en las cefaleas o neuralgias craneofaciales primarias y una segunda que se focaliza en las cefaleas secundarias. El enfoque es práctico con tablas que resumen los criterios de derivación con exploraciones complementarias y otros especialistas a los que derivar, para que sea útil y facilite su uso en nuestra práctica asistencial diaria. CONCLUSIONES: Esperamos ofrecer una guía y herramientas para mejorar la toma de decisiones ante un paciente con cefalea, valorando exploraciones a priorizar y qué circuitos seguir para así evitar la duplicación de consultas y retrasos en el diagnóstico y en el tratamiento


INTRODUCTION: When a patient is diagnosed with primary headache or craniofacial neuralgia in the emergency department or in primary care, and is referred to a neurologist due to the complexity of the case, it is useful to know whether additional examination should be sought and the priority (urgent, preferential or normal) with which the patient should be seen. This will avoid unnecessary delays in patients with disabling headache and where organic causes are suspected. In order to issue recommendations on this matter, the Spanish Society of Neurology's Headache Study Group has decided to create a series of agreed recommendations constituting a referral protocol for patients with headache and/or craniofacial neuralgia. DEVELOPMENT: Young neurologists with an interest and experience in headache were invited to draft a series of practical guidelines in collaboration with Spanish Society of Neurology's Headache Study Group Executive Committee. For practical reasons, the document was divided into 2 articles: this first article focuses on primary headaches and craniofacial neuralgias and the second on secondary headaches. In order for the recommendations to be helpful for daily practice they follow a practical approach, with tables summarising referral criteria, examinations to be performed, and referral to other specialists. CONCLUSIONS: We hope to offer a guide and tools to improve decision-making regarding patients with headache, identifying complementary tests to prioritise and referral pathways to be followed, in order to avoid duplicated consultations and delayed diagnosis and treatment


Subject(s)
Humans , Emergency Service, Hospital , Guidelines as Topic/standards , Headache/diagnosis , Neuralgia/diagnosis , Neurology , First Aid , Referral and Consultation , Decision Making , Headache/classification , Societies , Specialization
8.
Neurologia (Engl Ed) ; 35(3): 176-184, 2020 Apr.
Article in English, Spanish | MEDLINE | ID: mdl-28870393

ABSTRACT

INTRODUCTION: When a patient is diagnosed with primary headache or craniofacial neuralgia in the emergency department or in primary care, and is referred to a neurologist due to the complexity of the case, it is useful to know whether additional examination should be sought and the priority (urgent, preferential or normal) with which the patient should be seen. This will avoid unnecessary delays in patients with disabling headache and where organic causes are suspected. In order to issue recommendations on this matter, the Spanish Society of Neurology's Headache Study Group has decided to create a series of agreed recommendations constituting a referral protocol for patients with headache and/or craniofacial neuralgia. DEVELOPMENT: Young neurologists with an interest and experience in headache were invited to draft a series of practical guidelines in collaboration with Spanish Society of Neurology's Headache Study Group Executive Committee. For practical reasons, the document was divided into 2 articles: this first article focuses on primary headaches and craniofacial neuralgias and the second on secondary headaches. In order for the recommendations to be helpful for daily practice they follow a practical approach, with tables summarising referral criteria, examinations to be performed, and referral to other specialists. CONCLUSIONS: We hope to offer a guide and tools to improve decision-making regarding patients with headache, identifying complementary tests to prioritise and referral pathways to be followed, in order to avoid duplicated consultations and delayed diagnosis and treatment.


Subject(s)
Emergency Service, Hospital , Guidelines as Topic/standards , Headache/diagnosis , Neuralgia/diagnosis , Neurology , Primary Health Care , Referral and Consultation , Decision Making , Headache/classification , Humans , Societies , Specialization
9.
Neurologia (Engl Ed) ; 2019 Apr 29.
Article in English, Spanish | MEDLINE | ID: mdl-31047730

ABSTRACT

INTRODUCTION: Headache is one of the most common neurological complaints, and is most frequent during reproductive age. As a result, we are routinely faced with pregnant or breastfeeding women with this symptom in clinical practice. It is important to know which pharmacological choices are the safest, which should not be used, and when we should suspect secondary headache. To this end, the Spanish Society of Neurology's Headache Study Grouphas prepared a series of consensus recommendations on the diagnostic and therapeutic algorithms that should be followed during pregnancy and breastfeeding. DEVELOPMENT: This guide was prepared by a group of young neurologists with special interest and experience in headache, in collaboration with the Group's Executive Committee. Recommendations focus on which drugs should be used for the most frequent primary headaches, both during the acute phase and for prevention. The second part addresses when secondary headache should be suspected and which diagnostic tests should be performed in the event of possible secondary headache during pregnancy and breastfeeding. CONCLUSIONS: We hope this guide will be practical and useful in daily clinical practice and that it will help update and improve understanding of headache management during pregnancy and breastfeeding, enabling physicians to more confidently treat these patients.

10.
Front Plant Sci ; 10: 301, 2019.
Article in English | MEDLINE | ID: mdl-31001289

ABSTRACT

The horticultural industry demands high-quality resources to achieve excellence in yield and optimal revenues. Nitrogen is a pivotal nutrient to accomplish these goals for plant growth and product quality. However, competition for water in semi-arid regions can force the use of brackish waters, which can impair N uptake. The lower N uptake can be due to several reasons, such as an antagonism between ions, an absence of ATP, and/or alteration of N metabolism. The effect of supplying N as NO 3 - alone or in combination with NH 4 + , coupled with low or high salinity (8 or 20 mM NaCl), has been studied in sweet pepper fruits (Capsicum annuum L. cv. Melchor). The application of NH 4 + at high salinity affected chromatic parameters (a∗, b∗, and C∗), while chlorophyll a and b levels declined and ß-carotene increased. The concentrations of P, K, Ca, Mg, and Cu were reduced in the fruits of plants irrigated with NH 4 + . The concentration of Na was only reduced when NH 4 + was supplied. Likewise, the concentration of total phenolics was also reduced at high salinity. However, total protein was unaffected. The amino acid profile was altered by the supply of NH 4 + , which reduced the concentrations of histidine and phenylalanine. Moreover, the concentrations of putrescine and cadaverine were increased by NH 4 + at high salinity, whereas that of cadaverine was reduced by NH 4 + at low salinity. The observed changes in fruit quality triggered by salinity, under the conditions of this study, should be borne in mind for this crop with regard to the envisaged palliative effect of the supply of N- NH 4 + .

11.
Int J Biol Macromol ; 133: 270-277, 2019 Jul 15.
Article in English | MEDLINE | ID: mdl-31005688

ABSTRACT

The objective of this work is to obtain a stable and natural antimicrobial delivery system. Thus, the effect of the addition of a natural polysaccharide such as welan gum on the linear viscoelastic properties, flow behaviour, droplet size distribution and physical stability of thyme oil/W emulsions formulated with a wheat-derived surfactant was studied. All emulsions obtained show submicron diameters regardless of the concentration of welan. Emulsion without gum shows Newtonian behaviour under steady shear. Meanwhile, emulsions containing welan gum show a weak gel-like behaviour with higher G' and G″ values on increasing the content of gum in the emulsion. Their flow curves illustrate a shear thinning behaviour with much greater viscosity than that exhibited by emulsions without gum. This behaviour fits well to the Cross model. The main destabilization process of thyme oil/W emulsion without gum is creaming versus flocculation and coalescence in emulsions containing welan. Rheology, diffraction laser and multiple light scattering techniques have proved that welan gum is an important rheological modifier for thyme oil/W ecological emulsions, it being possible to control the rheological properties of these emulsions by adjusting the concentration of gum. However, welan gum does not improve the physical stability of these emulsions.


Subject(s)
Oils, Volatile/chemistry , Plant Gums/chemistry , Polysaccharides, Bacterial/chemistry , Thymus Plant/chemistry , Water/chemistry , Emulsions , Food Industry , Materials Testing , Rheology
12.
Neurología (Barc., Ed. impr.) ; 34(1): 22-26, ene.-feb. 2019. graf, tab
Article in Spanish | IBECS | ID: ibc-177275

ABSTRACT

Introducción: La cefalea produce un impacto negativo sobre la calidad de vida de los jóvenes. Nuestro objetivo es analizar las características de esta población en una consulta monográfica de cefaleas (CMC) y evaluar la carga de las diferentes cefaleas codificadas según la Clasificación Internacional de Cefaleas (CIC). Métodos: Durante un período de 6 años y medio, se han registrado los pacientes de edades entre los 14 y los 25 años atendidos en la CMC recogiendo de cada uno de ellos el sexo, pruebas complementarias y tratamiento utilizado previamente. Se llevó a cabo la comparación de las características de esta población con la de mayores de 25 años. Resultados: Seiscientos cincuenta y un pacientes de entre 14 y 25 años fueron atendidos durante el período de inclusión; el 95,6% había recibido tratamiento sintomático y el 30,1% tratamiento preventivo. Setecientas cincuenta y cinco cefaleas fueron registradas, 80 fueron cefaleas secundarias, la mayoría codificadas en el grupo 8. El 77,2% de ellas fueron incluidas en el grupo 1, el 3,1% en el grupo 2, el 1,2% en el grupo 3 y el 5% en el grupo 4. El 0,6% de ellas fueron clasificadas en el grupo 13 y el 0,9% en el grupo 14. En 449 pacientes la puntuación del Headache Impact Test (HIT-6) mostró al menos un impacto moderado sobre la calidad de vida. Conclusión: La mayoría de las cefaleas en jóvenes podrían ser codificadas de acuerdo con los criterios de la CIC. La migraña fue el diagnóstico más frecuente. Aunque la cefalea fue comúnmente asociada con impacto negativo en la calidad de vida, los tratamientos preventivos no fueron utilizados extensamente antes de ser derivados a la CMC


Introduction: Headache has a negative impact on health-related quality of life in young patients. We aim to analyse the characteristics of a series of young patients visiting a headache clinic and estimate the burden of different types of headaches listed by the International Classification of Headache Disorders (ICHD). Methods: We prospectively recruited patients aged 14 to 25 years who were treated at our clinic during a period of 6.5 years. We recorded each patient's sex, complementary test results, and previous treatment. We subsequently compared the characteristics of our sample to those of patients older than 25. Results: During the study period, we treated 651 patients aged 14 to 25 years; 95.6% had received symptomatic treatment, and 30.1% had received preventive treatment. A total of 755 headaches were recorded. Only 80 were secondary headaches, most of which were included in Group 8; 77.2% were included in Group 1, 3.1% in Group 2, 1.2% in Group 3, 5% in Group 4, 0.6% in Group 13, and 0.9% in Group 14. According to Headache Impact Test (HIT-6) scores, headache had at least a moderate impact on the quality of life of 449 patients. Conclusion: Most headaches in young patients can be classified according to ICHD criteria. Migraine was the most frequent diagnosis in our sample. Although headache was commonly associated with a negative impact on quality of life, most patients had received little preventive treatment before being referred to our clinic


Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Vascular Headaches/diagnosis , Headache Disorders/diagnosis , Age Factors , Vascular Headaches/classification , Headache Disorders/classification , Prospective Studies , Quality of Life
13.
J Stomatol Oral Maxillofac Surg ; 120(5): 474-475, 2019 Nov.
Article in English | MEDLINE | ID: mdl-30641279

ABSTRACT

Successful head and neck reconstructive microsurgery requires a multidisciplinary approach involving specialists such as maxillofacial surgeons, plastic surgeons, otolaryngologists, anaesthesiologists, and nurses. It requires strict perioperative management of the patient, with special attention paid to parameters such as blood pressure, ventilation, and bleeding, which can all impact flap perfusion. In high-volume centers, specially-trained microsurgery units are available for optimal control of flap monitoring and management of all aspects of patient care. However, during the beginning of a microsurgery unit at a hospital unfamiliar with the demands of this field, easy-to-follow, but effective, measures must be in place to ensure adoption and adherence to post-operative care principles that confer higher success rates in head and neck cancer patients undergoing free flap reconstruction. While frequent observations can be labor-intensive, clinical monitoring remains the most suitable method during this early period and requires appropriate experience to be effective. Our aim is to emphasize the importance of clinical monitoring during the beginnings of a microsurgery unit by introducing an easy-to-follow clinical monitoring chart that covers both intraluminal and extraluminal causes of free flap compromise.


Subject(s)
Free Tissue Flaps , Plastic Surgery Procedures , Humans , Microsurgery , Postoperative Complications , Tertiary Care Centers
14.
Neurologia (Engl Ed) ; 34(1): 22-26, 2019.
Article in English, Spanish | MEDLINE | ID: mdl-28087086

ABSTRACT

INTRODUCTION: Headache has a negative impact on health-related quality of life in young patients. We aim to analyse the characteristics of a series of young patients visiting a headache clinic and estimate the burden of different types of headaches listed by the International Classification of Headache Disorders (ICHD). METHODS: We prospectively recruited patients aged 14 to 25 years who were treated at our clinic during a period of 6.5 years. We recorded each patient's sex, complementary test results, and previous treatment. We subsequently compared the characteristics of our sample to those of patients older than 25. RESULTS: During the study period, we treated 651 patients aged 14 to 25 years; 95.6% had received symptomatic treatment, and 30.1% had received preventive treatment. A total of 755 headaches were recorded. Only 80 were secondary headaches, most of which were included in Group 8; 77.2% were included in Group 1, 3.1% in Group 2, 1.2% in Group 3, 5% in Group 4, 0.6% in Group 13, and 0.9% in Group 14. According to Headache Impact Test (HIT-6) scores, headache had at least a moderate impact on the quality of life of 449 patients. CONCLUSION: Most headaches in young patients can be classified according to ICHD criteria. Migraine was the most frequent diagnosis in our sample. Although headache was commonly associated with a negative impact on quality of life, most patients had received little preventive treatment before being referred to our clinic.


Subject(s)
Headache Disorders/diagnosis , Headache/diagnosis , Adolescent , Adult , Age Factors , Female , Headache/classification , Headache Disorders/classification , Humans , Male , Migraine Disorders/classification , Migraine Disorders/diagnosis , Prospective Studies , Quality of Life , Tension-Type Headache/classification , Tension-Type Headache/diagnosis , Young Adult
15.
Colloids Surf B Biointerfaces ; 173: 486-492, 2019 Jan 01.
Article in English | MEDLINE | ID: mdl-30336410

ABSTRACT

In the present work aqueous-based emulsions formulated with bio-based solvents and surfactants were studied. The droplet size distribution, rheology and physical stability of rosemary essential oil/water emulsions formulated with an emulsifier derived from wheat waste (alkyl polypentoside) were investigated as a function of the dispersed phase concentration (10-50 wt%) by means of laser diffraction, multiple light scattering and rheology measurements. Subsequently, processing variables, such as the pressure and the number of microfluidization passes, were studied to the best formulation (20 wt% rosemary oil). The laser diffraction technique revealed that monodispersed submicron emulsions were obtained for oil phase concentrations below 20 wt%. All emulsions showed Newtonian behavior, except for the emulsion containing 50 wt% oil, which exhibited shear-thinning properties. Moreover, the main destabilization mechanism of all the emulsions was creaming. The combination of techniques used demonstrated that the emulsion containing 20 wt% rosemary essential oil (REO) and prepared by microfluidization at 2500 psi (17.2 MPa) exhibited the longest physical stability and the smallest droplet size after 3passes. This research is a contribution to sustainable development not only by using chemicals derived from renewable raw materials but also by achieving stable emulsions with a low surfactant/oil mass ratio.


Subject(s)
Green Chemistry Technology , Nanostructures/chemistry , Oils, Volatile/chemistry , Surface-Active Agents/chemistry , Water/chemistry , Emulsions , Humans , Rheology , Surface-Active Agents/isolation & purification , Triticum/chemistry
19.
Plant Cell Environ ; 41(5): 908-918, 2018 05.
Article in English | MEDLINE | ID: mdl-28107563

ABSTRACT

High CO2 is able to ameliorate some negative effects due to climate change and intensify others. This study involves the sweet cherry (Prunus avium) cultivar 'Burlat' grafted on the 'Mariana 2624', 'Adara' and 'LC 52' rootstocks. In a climate chamber at two CO2 concentrations, ambient (400 µmol mol-1 ) and elevated (800 µmol mol-1 ), the plants were submitted to waterlogging for 7 d, followed by 7 d of recovery after drainage. Waterlogging drastically decreased the rate of photosynthesis, significantly endangering plant survival, particularly for the 'LC 52' and 'Adara' rootstocks. 'Mariana 2624' was also clearly affected by waterlogging that increased lipid peroxidation and the Cl- and SO42- concentrations in all the studied plants. Nevertheless, CO2 was able to overcome this reduction in photosynthesis, augmenting growth, increasing soluble sugars and starch, raising turgor and regulating the concentrations of Cl- and SO42- , while lowering the NO3- concentration in leaves of all the studied rootstocks. In concordance with these results, the proline levels indicated a more intense stress at control CO2 than at high CO2 for waterlogged plants. 'Mariana 2624' was more resistant to waterlogging than 'Adara', and both were more resistant than 'LC 52' in control CO2 conditions; this clearly enhanced the chance of survival under hypoxia.


Subject(s)
Carbon Dioxide/physiology , Oxygen/metabolism , Prunus avium/physiology , Water/physiology , Adaptation, Physiological , Climate Change , Floods , Photosynthesis/physiology , Plant Leaves/physiology , Plant Roots/physiology , Stress, Physiological , Time Factors
20.
J Plant Physiol ; 213: 178-187, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28407490

ABSTRACT

Climate change is submitting countries of the Mediterranean arc to periods of drought alternating with heavy rain and waterlogging. Eventual floods along with the rising CO2 in the atmosphere present an unpredictable scenario that affects crop survival. The effect of both stresses combined has been studied in sweet cherry plants. 'Gisela 5' and 'Gisela 6' were evaluated as rootstocks of the sweet cherry cultivar 'Burlat'. Plants were placed in a controlled-climate chamber for 7days, then they were submitted to waterlogging for another 7days and the response to this stress and the subsequent recovery were studied (7 more days). The experiment was carried out at 400µmolmol-1 CO2 (ambient CO2) and 800µmolmol-1 CO2, at 26°C, and plant water status and growth, net CO2 assimilation, transpiration, stomatal conductance, water potential, chlorophyll fluorescence, relative water content, anions content, proline, lipid peroxidation, soluble sugars, and starch were measured. Differences in the response and in its intensity were detected in both rootstocks. Some parameters - such as photosynthesis, soluble sugars, starch, TBARS, and NO3- - varied depending on the CO2 conditions and the waterlogging effect. Elevated CO2 was able to increase photosynthesis and thereby help plants to overcome waterlogging.


Subject(s)
Carbon Dioxide/metabolism , Climate Change , Prunus avium/metabolism , Prunus/metabolism , Nitrates/metabolism , Photosynthesis/physiology , Plant Leaves/metabolism , Plant Leaves/physiology , Plant Roots/metabolism , Plant Roots/physiology , Prunus/physiology , Prunus avium/physiology
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