[Modification of the pharmacokinetics of some antibiotics by oral administration with an L-(-)verbenone beta-cyclodextrin complex]. / Modifiche della farmacocinetica di alcuni antibiotici dopo somministrazione orale del complesso L(-) Verbenone/betaciclodestrina.

With the aim to evaluate the effect of L (-) Verbenone on the pharmacokinetic of some antibiotics, a compound has been prepared with beta cyclodextrin, allowing the administration per os. Pharmacological studies have been carried out using erythromycin and ampicillin, determining their kinetics in the hepatic and lung tissues after administration to albino mice. The results show that L (-) Verbenone modifies the distribution of the antibiotics used; it increases their concentration at lung level while the concentration at hepatic level remains unchanged.

[Biological and HPLC analysis of heparin after thermal treatment]. / Analisi biologica e HPLC di eparina trattata termicamente.

Heparin solutions ampoules have been autoclaved at 105 degrees C-110 degrees C-121 degrees C-134 degrees C for 15 minutes. The biological activity has not decreased after the treatment, but a reduction was observed after a storage period of 36 months at room temperature for sterilizing treatments. Analysis of heparin by size exclusion and reversed phase HPLC with the method developed in our laboratories allowed us to demonstrate a substantial stability of the molecular structure. These methods showed to be suitable for a qualitative evaluation of the heparin itself.