Cardiovascular disease detection using a novel stack-based ensemble classifier with aggregation layer, DOWA operator, and feature transformation.

Due to their widespread prevalence and impact on quality of life, cardiovascular diseases (CVD) pose a considerable global health burden. Early detection and intervention can reduce the incidence, severity, and progression of CVD and prevent premature death. The application of machine learning (ML) techniques to early CVD detection is therefore a valuable approach. In this paper, A stack-based ensemble classifier with an aggregation layer and the dependent ordered weighted averaging (DOWA) operator is proposed for detecting cardiovascular diseases. We propose transforming features using the Johnson transformation technique and normalizing feature distributions. Three diverse first-level classifiers are selected based on their accuracy, and predictions are combined using the aggregation layer and DOWA. A linear support vector machine (SVM) meta-classifier makes the final classification. Adding the aggregation layer to the stacking classifier improves classification accuracy significantly, according to the study. The accuracy is enhanced by 5%, resulting in an impressive overall accuracy of 94.05%. Moreover, the proposed system significantly increases the area under the receiver operating characteristic (ROC) curve compared to recent studies, reaching 97.14%. It further reinforces the classifier's reliability and effectiveness in classifying cardiovascular disease by distinguishing between positive and negative instances. With improved accuracy and a high area under the curve (AUC), the proposed classifier exhibits robustness and superior performance in the detection of cardiovascular diseases.

A Spatio-Temporal Graph Convolutional Network Model for Internet of Medical Things (IoMT).

In order to provide intelligent and efficient healthcare services in the Internet of Medical Things (IoMT), human action recognition (HAR) can play a crucial role. As a result of their stringent requirements, such as high computational complexity and memory efficiency, classical HAR techniques are not applicable to modern and intelligent healthcare services, e.g., IoMT. To address these issues, we present in this paper a novel HAR technique for healthcare services in IoMT. This model, referred to as the spatio-temporal graph convolutional network (STGCN), primarily aims at skeleton-based human-machine interfaces. By independently extracting spatial and temporal features, STGCN significantly reduces information loss. Spatio-temporal information is extracted independently of the exact spatial and temporal point, ensuring the extraction of useful features for HAR. Using only joint data and fewer parameters, we demonstrate that our proposed STGCN achieved 92.2% accuracy on the skeleton dataset. Unlike multi-channel methods, which use a combination of joint and bone data and have a large number of parameters, multi-channel methods use both joint and bone data. As a result, STGCN offers a good balance between accuracy, memory consumption, and processing time, making it suitable for detecting medical conditions.

Gene expression profiles and pathway enrichment analysis to identification of differentially expressed gene and signaling pathways in epithelial ovarian cancer based on high-throughput RNA-seq data.

Epithelial ovarian cancer (EOC) can be considered as a stressful and challenging disease among all women in the world, which has been associated with a poor prognosis and its molecular pathogenesis has remained unclear. In recent years, RNA Sequencing (RNA-seq) has become a functional and amazing technology for profiling gene expression. In the present study, RNA-seq raw data from Sequence Read Archive (SRA) of six tumor and normal ovarian sample was extracted, and then analysis and statistical interpretation was done with Linux and R Packages from the open-source Bioconductor. Gene Ontology (GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were applied for the identification of key genes and pathways involved in EOC. We identified 1091 Differential Expression Genes (DEGs) which have been reported in various studies of ovarian cancer as well as other types of cancer. Among them, 333 genes were up-regulated and 273 genes were down-regulated. In addition, Differentially Expressed Genes (DEGs) including RPL41, ALDH3A2, ERBB2, MIEN1, RBM25, ATF4, UPF2, DDIT3, HOXB8 and IL17D as well as Ribosome and Glycolysis/Gluconeogenesis pathway have had the potentiality to be used as targets for EOC diagnosis and treatment. In this study, unlike that of any other studies on various cancers, ALDH3A2 was most down-regulated gene in most KEGG pathways, and ATF4 was most up-regulated gene in leucine zipper domain binding term. In the other hand, RPL41 as a regulatory of cellular ATF4 level was up-regulated in many term and pathways and augmentation of ATF4 could justify the increase of RPL41 in the EOC. Pivotal pathways and significant genes, which were identified in the present study, can be used for adaptation of different EOC study. However, further molecular biological experiments and computational processes are required to confirm the function of the identified genes associated with EOC.

[Treatment of premature ventricular contractions in patients with structural heart disease : Insights from imaging]. / Therapie der ventrikulären Extrasystolen bei strukturellen Herzerkrankungen : Welchen Mehrwert hat die Bildgebung?

The diagnosis of premature ventricular contractions (PVC) is presumptively based on the presence of frequent symptoms. Particularly in patients with a relatively low PVC burden, the relationship between the PVCs and an individual arrhythmia substrate can be challenging to ascertain. Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) has been found to be beneficial in identifying the presence of potential individual arrhythmia substrates even in patients with normal left ventricular function. Consequently, CMR has been useful in risk stratification of patients with PVCs. The authors aimed to demonstrate and discuss the current role and future use of CMR in the diagnostic algorithm to guide PVC ablation.