1.
J Labelled Comp Radiopharm
; 60(12): 577-585, 2017 10.
Article
in English
| MEDLINE
| ID: mdl-28763109
ABSTRACT
An 8-step preparation of 14 C-labelled CHF6001, a potent phosphodiesterase 4 inhibitor in the treatment of respiratory diseases, is described. An overall yield of approximately 9% was obtained starting from copper[14 C]cyanide. The synthesis of a stable labelled version of CHF6001 is also reported using the commercially available trideuterated bromomethylcyclopropane as starting material.
Subject(s)
Carbon Radioisotopes/chemistry , Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism , Deuterium/chemistry , Phosphodiesterase 4 Inhibitors/chemistry , Phosphodiesterase 4 Inhibitors/chemical synthesis , Sulfonamides/chemistry , Sulfonamides/chemical synthesis , para-Aminobenzoates/chemistry , para-Aminobenzoates/chemical synthesis , Chemistry Techniques, Synthetic , Isotope Labeling , Phosphodiesterase 4 Inhibitors/pharmacology , Sulfonamides/pharmacology , para-Aminobenzoates/pharmacology
2.
Policlinico Med
; 73(6): 361-75, 1966 Dec.
Article
in Italian
| MEDLINE
| ID: mdl-5998805
