1.
Chem Pharm Bull (Tokyo)
; 36(8): 2766-71, 1988 Aug.
Article
in English
| MEDLINE
| ID: mdl-3240502
2.
Arzneimittelforschung
; 35(10): 1550-2, 1985.
Article
in English
| MEDLINE
| ID: mdl-4074414
ABSTRACT
Using a pharmacological model, the comparison between acetylsalicylic acid (ASA), administered orally, and a solution combining two salicylate derivatives (ethyl 5-methoxy-salicylate and 3-phenyl-propyl-salicylate), applied locally, demonstrated the value of the local application. Indeed, the pharmacological activity was highly significant and directly related to the tissue concentration of salicyl ions, which was higher after local application of the solution than after oral administration of ASA. The local solution also resulted in a lower plasma concentration of salicylate ions, allowing high plasma salicylate concentrations to be avoided.