Subject(s)
Bone Neoplasms , Hemangioendothelioma, Epithelioid , Sphenoid Bone/pathology , Adult , Antigens, CD34/metabolism , Bone Neoplasms/diagnosis , Bone Neoplasms/metabolism , Female , Hemangioendothelioma, Epithelioid/diagnosis , Hemangioendothelioma, Epithelioid/metabolism , Humans , Magnetic Resonance Imaging , Microfilament Proteins/metabolism , Mucin-1/metabolism , Platelet Endothelial Cell Adhesion Molecule-1/metabolism , Receptors, Cytoplasmic and Nuclear/metabolism , Tomography Scanners, X-Ray Computed , Trans-ActivatorsABSTRACT
ortho-Acylation attempt of benzenesulfonamide afforded the corresponding hemiaminal as major product. The in situ reduction of the reaction mixture, reported herein, directly provided 2-hydroxyalkyl benzenesulfonamide, an important pharmacophoric element for designing drug-like scaffolds. Its application is demonstrated through designing a novel series of 1,5-diarylpyrazoles for cyclooxygenase-2 (COX-2) inhibition.
Subject(s)
Aldehydes/chemistry , Alkanes/chemistry , Sulfonamides/chemistry , gamma-Aminobutyric Acid , Carbonic Anhydrase Inhibitors/chemistry , Chemistry, Pharmaceutical , Drug Design , Models, Molecular , Molecular Structure , Oxidation-Reduction , BenzenesulfonamidesABSTRACT
An investigation of the chemistry of ginkgolides A, B and C (1) has revealed an unusual interaction between the hydroxyl groups at C(1) and C(10) which activates their deprotonation to give 2 and provides a method for the interconversion of 1C and 1B. The ginkgolide 7-enol system 7 is more stable than the corresponding 7-keto form 6, which is easily made by selective Jones oxidation of ginkgolide C.