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1.
J Clin Child Adolesc Psychol ; : 1-15, 2023 Dec 01.
Article in English | MEDLINE | ID: mdl-38039086

ABSTRACT

OBJECTIVE: Research on the role of affect in childhood aggression motives has largely focused on domain-level affective traits. Lower-order affective facets may show more distinct relationships with instrumental and reactive aggression - at both the variable and individual levels - and offer unique insights into whether and how several forms of affect are involved in aggression motives. METHOD: Caregivers (98% mothers) of 342 children (Mage = 9.81 years, 182 girls, 31% White) reported on children's aggression and affect-relevant personality traits, personality pathology, and callous-unemotional traits. RESULTS: Both reactive and instrumental aggressions were characterized by higher levels of trait irritability, fear, withdrawal, sadness, and callous-unemotional traits in zero-order analyses. Instrumental aggression was characterized by low trait positive emotions. Reactive aggression was uniquely associated with irritability, fear, withdrawal, and sadness, whereas instrumental aggression was uniquely associated with callous-unemotional traits and (low) positive emotions. Groups identified by latent profile analyses were differentiated only by aggression severity. CONCLUSIONS: The findings support both the similarity and distinction of reactive and instrumental aggression vis-à-vis their affective phenomenology. Consistent with existing theories, reactive aggression was linked to multiple forms of negative emotionality, whereas instrumental aggression was linked to higher levels of callous-unemotional traits. In a novel finding, instrumental aggression was uniquely characterized by lower positive emotions. The findings highlight the utility of pre-registered approaches employing comprehensive personality-based affective frameworks to organize and understand similarities and differences between aggression functions.

2.
Perspect Psychol Sci ; 18(4): 829-842, 2023 07.
Article in English | MEDLINE | ID: mdl-36350711

ABSTRACT

Leadership traits and behaviors are observed early in human development, and although an improved understanding of youth leadership would usefully inform many real-world contexts (e.g., education, parenting, policy), most empirical work on leadership has been limited to adult populations. The purpose of the current article is to add a developmental perspective to leadership research that has so far been absent. Here, we (a) highlight adolescence as a critical developmental period for leadership emergence and development, (b) argue that leadership among youths is poorly understood and critically understudied, (c) provide exemplars of synergy between research on leadership and adolescent development that are ripe for focused inquiry, and (d) underscore some of the positive consequences of accelerating empirical research on leadership in adolescence, including implications for a deeper understanding of leadership in adult working populations.


Subject(s)
Leadership , Adult , Humans , Adolescent , Educational Status
3.
Personal Disord ; 13(4): 360-363, 2022 07.
Article in English | MEDLINE | ID: mdl-35787121

ABSTRACT

Personality disorder (PD) researchers proposed a highly innovative "paradigm-shifting" revamp for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (APA, 2013). Yet, 10 years later, Widiger and Hines (2022) summarize a developmental process plagued by disagreement and stagnation, with little evidence of the field having reaped the desired benefits of this diagnostic revolution. In this commentary, we draw on principles from entrepreneurial creation, operation, and success-positioning the PD scientists in the role of "disruptive innovator"-and summarize key principles from the entrepreneurial process that may be relevant in understanding the challenges and failures of the PD revolution to date. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Subject(s)
Personality Disorders , Diagnostic and Statistical Manual of Mental Disorders , Humans , Personality Disorders/diagnosis
4.
JAMA ; 327(15): 1456-1468, 2022 04 19.
Article in English | MEDLINE | ID: mdl-35381069

ABSTRACT

Importance: Corticosteroids improve strength and function in boys with Duchenne muscular dystrophy. However, there is uncertainty regarding the optimum regimen and dosage. Objective: To compare efficacy and adverse effects of the 3 most frequently prescribed corticosteroid regimens in boys with Duchenne muscular dystrophy. Design, Setting, and Participants: Double-blind, parallel-group randomized clinical trial including 196 boys aged 4 to 7 years with Duchenne muscular dystrophy who had not previously been treated with corticosteroids; enrollment occurred between January 30, 2013, and September 17, 2016, at 32 clinic sites in 5 countries. The boys were assessed for 3 years (last participant visit on October 16, 2019). Interventions: Participants were randomized to daily prednisone (0.75 mg/kg) (n = 65), daily deflazacort (0.90 mg/kg) (n = 65), or intermittent prednisone (0.75 mg/kg for 10 days on and then 10 days off) (n = 66). Main Outcomes and Measures: The global primary outcome comprised 3 end points: rise from the floor velocity (in rise/seconds), forced vital capacity (in liters), and participant or parent global satisfaction with treatment measured by the Treatment Satisfaction Questionnaire for Medication (TSQM; score range, 0 to 100), each averaged across all study visits after baseline. Pairwise group comparisons used a Bonferroni-adjusted significance level of .017. Results: Among the 196 boys randomized (mean age, 5.8 years [SD, 1.0 years]), 164 (84%) completed the trial. Both daily prednisone and daily deflazacort were more effective than intermittent prednisone for the primary outcome (P < .001 for daily prednisone vs intermittent prednisone using a global test; P = .017 for daily deflazacort vs intermittent prednisone using a global test) and the daily regimens did not differ significantly (P = .38 for daily prednisone vs daily deflazacort using a global test). The between-group differences were principally attributable to rise from the floor velocity (0.06 rise/s [98.3% CI, 0.03 to 0.08 rise/s] for daily prednisone vs intermittent prednisone [P = .003]; 0.06 rise/s [98.3% CI, 0.03 to 0.09 rise/s] for daily deflazacort vs intermittent prednisone [P = .017]; and -0.004 rise/s [98.3% CI, -0.03 to 0.02 rise/s] for daily prednisone vs daily deflazacort [P = .75]). The pairwise comparisons for forced vital capacity and TSQM global satisfaction subscale score were not statistically significant. The most common adverse events were abnormal behavior (22 [34%] in the daily prednisone group, 25 [38%] in the daily deflazacort group, and 24 [36%] in the intermittent prednisone group), upper respiratory tract infection (24 [37%], 19 [29%], and 24 [36%], respectively), and vomiting (19 [29%], 17 [26%], and 15 [23%]). Conclusions and Relevance: Among patients with Duchenne muscular dystrophy, treatment with daily prednisone or daily deflazacort, compared with intermittent prednisone alternating 10 days on and 10 days off, resulted in significant improvement over 3 years in a composite outcome comprising measures of motor function, pulmonary function, and satisfaction with treatment; there was no significant difference between the 2 daily corticosteroid regimens. The findings support the use of a daily corticosteroid regimen over the intermittent prednisone regimen tested in this study as initial treatment for boys with Duchenne muscular dystrophy. Trial Registration: ClinicalTrials.gov Identifier: NCT01603407.


Subject(s)
Glucocorticoids , Muscular Dystrophy, Duchenne , Prednisone , Child , Child, Preschool , Female , Glucocorticoids/administration & dosage , Glucocorticoids/adverse effects , Glucocorticoids/therapeutic use , Humans , Male , Muscular Dystrophy, Duchenne/drug therapy , Prednisone/administration & dosage , Prednisone/adverse effects , Prednisone/therapeutic use , Pregnenediones/adverse effects
5.
Ambio ; 51(4): 926-942, 2022 Apr.
Article in English | MEDLINE | ID: mdl-34523080

ABSTRACT

Climate change, overfishing, and other anthropogenic drivers are forcing marine resource users and decision makers to adapt-often rapidly. In this article we introduce the concept of pathways to rapid adaptation to crisis events to bring attention to the double-edged role that institutions play in simultaneously enabling and constraining swift responses to emerging crises. To develop this concept, we draw on empirical evidence from a case study of the iconic Maine lobster (Homarus americanus) industry. In the Gulf of Maine, the availability of Atlantic herring (Clupea harengus) stock, a key source of bait in the Maine lobster industry, declined sharply. We investigate the patterns of bait use in the fishery over an 18-year period (2002-2019) and how the lobster industry was able to abruptly adapt to the decline of locally-sourced herring in 2019 that came to be called the bait crisis. We found that adaptation strategies to the crisis were diverse, largely uncoordinated, and imperfectly aligned, but ultimately led to a system-level shift towards a more diverse and globalized bait supply. This shift was enabled by existing institutions and hastened an evolution in the bait system that was already underway, as opposed to leading to system transformation. We suggest that further attention to raceways may be useful in understanding how and, in particular, why marine resource users and coastal communities adapt in particular ways in the face of shocks and crises.


Subject(s)
Fisheries , Nephropidae , Animals , Climate Change , Conservation of Natural Resources , Maine
6.
J Consult Clin Psychol ; 89(5): 469-475, 2021 May.
Article in English | MEDLINE | ID: mdl-34124928

ABSTRACT

Objective: The goal of the present study was to replicate and extend published preliminary evidence demonstrating that a relatively new treatment (Achieving Change through Value-Based Behavior [ACTV]) for men convicted of domestic violence significantly reduces recidivism compared to the standard treatment offered across the United States (the Duluth Model and/or cognitive-behavioral approaches). Method: Men convicted of domestic assault (DA) and court-mandated to a Batterers Intervention Program [N = 725; Mage = 34.9 years (SDage = 10.37 years)] were assigned to attend ACTV or treatment-as-usual (TAU). Participants were predominantly Black (63.3%). Recidivism, defined as any new convictions, any violent convictions, and any DA convictions, was examined up to 5 years posttreatment. Only men classified as medium or high risk were included. Results: Men in TAU were more likely to receive any conviction (95% CI [1.61, 4.40]), a violent conviction (95% CI [1.67, 9.60]), and a DA conviction (95% CI [1.36, 4.90]) compared to men in ACTV. Time to new conviction posttreatment was shorter for men in TAU versus ACTV (95% CI [2.16, 4.11]). Finally, the risk of receiving any new conviction (95% CI [1.46, 7.11]) was more strongly associated with noncompletion for TAU than ACTV participants. Conclusions: ACTV shows great promise for reducing recidivism compared to TAU. The present study represents the first time this intervention has been implemented in a state other than where it was developed and provides initial evidence for its generalizability and robustness. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Subject(s)
Cognitive Behavioral Therapy/statistics & numerical data , Domestic Violence/statistics & numerical data , Recidivism/statistics & numerical data , Adolescent , Adult , Aggression , Humans , Male , United States/epidemiology , Young Adult
7.
Psychol Assess ; 33(9): 855-870, 2021 Sep.
Article in English | MEDLINE | ID: mdl-33956474

ABSTRACT

Relational aggression-or behavior intended to harm the relationships of its victims-has been the focus of interdisciplinary study across developmental, clinical, personality, and social psychology in the last several decades. One of the primary measures used to assess relational aggression in youth is the Children's Social Behavior Scale (CSBS; Crick & Grotpeter, 1995), but despite its common usage, the construct validity of this measure has not been comprehensively assessed. In the present study, we used a multistage construct validity framework to thoroughly investigate the nature of relational aggression across six community samples totaling 3,102 youth and their caregivers. We used multiple methods to map the reliability, internal or structural validity, and external validity of this scale. Through these analyses, we found that CSBS Relational Aggression demonstrated strong internal consistency, test-retest, and interrater reliability as well as a robust single factor structure and invariance across multiple demographic groups. External validity analyses positioned relational aggression within a theoretically consistent nomological net including psychopathology, personality, and social developmental factors. Contrary to concerns about the validity of self- and parent-reports of relational aggression, both parent- and youth-report forms of the CSBS Relational Aggression scale demonstrated strong reliability and validity. While construct validation has received inadequate attention in the psychological literature to date, through this project, we aimed to demonstrate how this approach may be used to investigate existing measures across psychological research. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Subject(s)
Aggression , Interpersonal Relations , Social Behavior , Surveys and Questionnaires , Adolescent , Aggression/psychology , Child , Humans , Reproducibility of Results
9.
Pediatr Diabetes ; 21(5): 814-823, 2020 08.
Article in English | MEDLINE | ID: mdl-32222056

ABSTRACT

OBJECTIVE: We explored the impact of TeKnO T1D, an online, case-based, spaced education curriculum about insulin pump and continuous glucose monitor (CGM) use in pediatric type 1 diabetes management. METHODS: Pediatric endocrinology fellows (n = 64) were randomized to receive an educational curriculum focused on either insulin pumps or CGMs. Fellows received interactive questions twice weekly via email or mobile app. Median time to completion was 76.5 days. The primary outcome was change in knowledge as measured by performance on multiple-choice questions (MCQ) from the pre-test to the post-test. RESULTS: Forty-eight of 64 (75%) learners completed the curriculum and assessments. The pump group improved from 35.0 ± 15% on the pre-test MCQs to 61.1 ± 17% on the post-test, a 12.2 absolute percentage point greater improvement on pump-specific items than the CGM group (P = .03). The CGM group improved from 30.3 ± 15% on the pre-test MCQs to 61.4 ± 21% on the post-test, a 28.7 absolute percentage point greater improvement on CGM-specific items than the pump group (P < .001). Both groups were more likely to report an appropriate level of understanding of their respective technologies after completing the corresponding curriculum. In thematic analysis of qualitative data, fellows indicated that knowledge gains led to improved patient care. There was universal agreement about enjoyment and effectiveness of the curricula. CONCLUSIONS: TeKnO T1D proved to be an engaging, effective way to improve endocrinology fellows' knowledge and confidence about insulin pumps and CGM use in the management of pediatric type 1 diabetes.


Subject(s)
Diabetes Mellitus, Type 1 , Endocrinology/education , Insulin Infusion Systems , Pediatrics/education , Technology/education , Adult , Blood Glucose Self-Monitoring/instrumentation , Child , Computer-Assisted Instruction/methods , Curriculum , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 1/drug therapy , Education, Distance/methods , Endocrinology/instrumentation , Female , Health Knowledge, Attitudes, Practice , Humans , Internship and Residency/methods , Internship and Residency/standards , Inventions , Male , Pediatrics/instrumentation
10.
J Pers Disord ; 34(Suppl B): 46-63, 2020 09.
Article in English | MEDLINE | ID: mdl-31682192

ABSTRACT

Low agreeableness features centrally in personality profiles of Cluster B personality disorder (PD) diagnoses, and it has been associated with relational aggression (RAgg; intentionally damaging others' social relationships). Researchers have hypothesized that RAgg may be a potential developmental precursor for Cluster B PDs. However, a dimensional approach to personality dysfunction is preferable to the categorical system found in the current diagnostic manual. To build a bridge between two disjointed literatures (categorical PDs and RAgg), the aim of this project is to detail how RAgg in youth is situated in the trait space represented by disagreeableness in a dimensional model of personality pathology. Caregivers of 911 youth (ages 6-18) reported on youth's RAgg and disagreeableness. We found that RAgg was most strongly related to three facets: Narcissistic traits, Hyperexpressive traits, and Dominance-Egocentrism traits. Overall, these findings provide support for RAgg as an early manifestation of personality pathology, particularly for narcissistic traits.


Subject(s)
Aggression , Personality Disorders , Adolescent , Child , Humans , Interpersonal Relations , Personality , Personality Disorders/diagnosis , Personality Inventory
11.
J Abnorm Psychol ; 128(6): 493-499, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31368728

ABSTRACT

Although an emphasis on adequate sample size and statistical power has a long history in clinical psychological science (Cohen, 1992), increased attention to the replicability of scientific findings has renewed focus on the importance of statistical power (Bakker, van Dijk, & Wicherts, 2012). These recent efforts have not yet circled back to modern clinical psychological research, despite the importance of sample size and power in producing a credible body of evidence. As one step in this process of scientific self-examination, the present study estimated an N-pact Factor (the statistical power of published empirical studies to detect typical effect sizes; Fraley & Vazire, 2014) in 2 leading clinical journals (the Journal of Abnormal Psychology [JAP] and the Journal of Consulting and Clinical Psychology [JCCP]) for the years 2000, 2005, 2010, and 2015. Study sample size, as one proxy for statistical power, is a useful focus because it allows comparisons with other subfields and may highlight some of the core methodological differences between clinical and other areas. We found that, across all years examined, the average median sample size in clinical research was 179 participants (175 for JAP and 182 for JCCP). The power to detect a small to medium effect size of .20 is just below 80% for both journals. Although the clinical N-pact factor was higher than that estimated for social psychology, the statistical power in clinical journals is still limited to detect many effects of interest to clinical psychologists, with little evidence of improvement in sample sizes over time. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Subject(s)
Biomedical Research/standards , Periodicals as Topic/statistics & numerical data , Psychology, Clinical/standards , Research Design/standards , Sample Size , Humans , Male
12.
Psychol Assess ; 31(12): 1386-1394, 2019 Dec.
Article in English | MEDLINE | ID: mdl-30869959

ABSTRACT

The last decade has seen enormous advances in research transparency in psychology. One of these advances has been the creation of a common interface for openness across the sciences-the Open Science Framework (OSF). While social, personality, and cognitive psychologists have been at the fore in participating in open practices on the OSF, clinical psychology has trailed behind. In this article, we discuss the advantages and special considerations for clinical assessment researchers' participation in open science broadly, and specifically in using the OSF for these purposes. We use several studies from our lab to illustrate the uses of the OSF for psychological studies, as well as the process of implementing this tool in assessment research. Among these studies are an archival assessment study, a project using an extensive unpublished assessment battery, and one in which we developed a short-form assessment instrument. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Subject(s)
Mental Disorders/diagnosis , Psychology, Clinical/methods , Research Design , Humans , Personality
13.
Curr Opin Psychol ; 21: 39-43, 2018 06.
Article in English | MEDLINE | ID: mdl-28963890

ABSTRACT

The reliable and valid assessment of personality disorders (PDs) faces several challenges in different domains. In particular, the variety of methods, settings, and informants relevant for PD assessment raises questions about best practices. Additionally, issues surrounding assessment across the lifespan, including youth and the elderly, further complicate PD assessment. We review these issues here and point toward future directions in PD assessment, with an emphasis on the utility of dimensional PD assessment.


Subject(s)
Personality Disorders/diagnosis , Personality Disorders/psychology , Age Factors , Diagnostic and Statistical Manual of Mental Disorders , Humans , Personality Assessment
14.
Personal Disord ; 9(3): 228-238, 2018 05.
Article in English | MEDLINE | ID: mdl-28095002

ABSTRACT

Relational aggression (RAgg) is a form of behavior intended to damage the victim's social status or interpersonal relationships through the use of purposeful interpersonal manipulation or social exclusion (Archer & Coyne, 2005). RAgg is impairing, stable, and largely defined by dysfunctional patterns of interpersonal interactions-all of which invokes comparisons to personality and, more specifically, personality pathology. Leveraging research using the Five Factor Model (FFM) in personality disorder (PD) work, the present study aims to understand the personality context of RAgg by applying this FFM profile approach in 2 ways: (a) by compiling a personality profile of RAgg based on a thorough review of the relevant literature and (b) by compiling a personality profile of RAgg based on expert ratings (N = 19). We then compared these profiles to each other and to existing personality profiles of Cluster B PDs to examine how RAgg fits into the personality space represented by Cluster B PDs. These analyses indicate that both FFM profiles of RAgg show substantial overlap with the FFM profile of narcissistic PD. The present study has important implications for bridging disjointed domains of research on personality pathology and RAgg and underscores the relevance of RAgg for early emergence of PD characteristics. (PsycINFO Database Record


Subject(s)
Aggression/physiology , Interpersonal Relations , Models, Psychological , Personality Disorders/physiopathology , Personality/physiology , Social Isolation , Adult , Humans , Personality/classification , Personality Disorders/classification
15.
Health Psychol ; 36(7): 662-672, 2017 07.
Article in English | MEDLINE | ID: mdl-28277700

ABSTRACT

OBJECTIVE: Race/ethnicity and socioeconomic status are both associated with stress physiology as indexed by cortisol. The present study tested the extent to which racial/ethnic disparities in cortisol reactivity are explained by socioeconomic status. METHOD: The sample consisted of 296 racially and socioeconomically diverse children ages 8-11 (47% boys). Mothers reported on children's stressors and socioeconomic status; salivary cortisol levels were assessed before and after the Trier Social Stress Test. RESULTS: Results demonstrated that racial group differences in cortisol reactivity were partially accounted for by differences in socioeconomic status, but racial group differences in cortisol recovery were not. CONCLUSIONS: These findings suggest that cumulative effects of stress and disadvantage may result in differences in stress response physiology as early as middle childhood, and that race-specific mechanisms account for additional variance in cortisol reactivity and recovery. (PsycINFO Database Record


Subject(s)
Hydrocortisone/metabolism , Social Class , Stress, Psychological/psychology , Child , Female , Humans , Male , Racial Groups
17.
Personal Ment Health ; 11(1): 4-13, 2017 02.
Article in English | MEDLINE | ID: mdl-27670747

ABSTRACT

Recent efforts have demonstrated that thin-slice (TS) assessment-or assessment of individual characteristics after only brief exposure to that individual's behaviour-can produce reliable and valid measurements of child personality traits. The extent to which this approach can be generalized to archival data not designed to measure personality, and whether it can be used to measure personality pathology traits in youth, is not yet known. Archival video data of a parent-child interaction task was collected as part of a clinical intervention trial for aggressive children (N = 177). Unacquainted observers independently watched the clips and rated children on normal-range (neuroticism, extraversion, agreeableness, conscientiousness and openness to experience) and pathological (callous-unemotional) personality traits. TS ratings of child personality showed strong internal consistency, valid associations with measures of externalizing problems and temperament, and revealed differentiated subgroups of children based on severity. As such, these findings demonstrate an ecologically valid application of TS methodology and illustrate how researchers and clinicians can extend their existing data by measuring child personality using TS methodology, even in cases where child personality was not originally measured. Copyright © 2016 John Wiley & Sons, Ltd.


Subject(s)
Child Behavior , Personality Assessment , Personality , Psychology, Child , Adolescent , Aggression , Child , Female , Humans , Male , Observer Variation , Parent-Child Relations , Personality Inventory , Psychometrics , Temperament
18.
Philos Trans R Soc Lond B Biol Sci ; 371(1689)2016 Mar 05.
Article in English | MEDLINE | ID: mdl-26880840

ABSTRACT

To forecast marine disease outbreaks as oceans warm requires new environmental surveillance tools. We describe an iterative process for developing these tools that combines research, development and deployment for suitable systems. The first step is to identify candidate host-pathogen systems. The 24 candidate systems we identified include sponges, corals, oysters, crustaceans, sea stars, fishes and sea grasses (among others). To illustrate the other steps, we present a case study of epizootic shell disease (ESD) in the American lobster. Increasing prevalence of ESD is a contributing factor to lobster fishery collapse in southern New England (SNE), raising concerns that disease prevalence will increase in the northern Gulf of Maine under climate change. The lowest maximum bottom temperature associated with ESD prevalence in SNE is 12 °C. Our seasonal outlook for 2015 and long-term projections show bottom temperatures greater than or equal to 12 °C may occur in this and coming years in the coastal bays of Maine. The tools presented will allow managers to target efforts to monitor the effects of ESD on fishery sustainability and will be iteratively refined. The approach and case example highlight that temperature-based surveillance tools can inform research, monitoring and management of emerging and continuing marine disease threats.


Subject(s)
Environmental Monitoring/methods , Nephropidae/microbiology , Animals , Atlantic Ocean , Climate Change , Conservation of Natural Resources , Fisheries , Forecasting , Host-Pathogen Interactions , Maine , Seasons , Temperature , Time Factors
19.
J Res Adolesc ; 26(3): 390-402, 2016 09.
Article in English | MEDLINE | ID: mdl-28581652

ABSTRACT

Previous investigations of testosterone and externalizing behavior have provided mixed findings. We tested the hypothesis that self-regulatory personality moderates the testosterone-externalizing behavior association in adolescence. Parents reported on their 13- to 18-year-old (N = 106, Mage = 16.01, SD = 1.29) children's personalities and psychopathology. Testosterone was measured via drool samples. As hypothesized, personality moderated the testosterone-externalizing behavior association. High testosterone predicted higher levels of externalizing behaviors, but only for adolescents low in Agreeableness and Conscientiousness. Also, personality acted as a resiliency factor: high levels of Conscientiousness, in the presence of high testosterone, predicted lower levels of rule breaking. Results highlight how endogenous factors, such as personality, may interact with testosterone, and emphasize the relevance of including personality moderators in future research.


Subject(s)
Personality Disorders , Testosterone , Adolescent , Humans , Parents , Personality
20.
Psychoneuroendocrinology ; 55: 146-53, 2015 May.
Article in English | MEDLINE | ID: mdl-25765756

ABSTRACT

Growing evidence has indicated that gonadal and stress hormones interact to shape socially dominant behavior and externalizing psychopathology; however, such work to date has focused exclusively on the testosterone-cortisol interaction, despite expectations that estradiol should be associated with similar behavioral outcomes to testosterone. Here, we present the first empirical test of the hypothesis that adolescent males and females (N=105, ages 13-18) with high estradiol and low cortisol concentrations are at highest risk for externalizing problems, but - replicating previous work - only among adolescents high on pathological personality traits. Parents reported on youth psychopathology and personality, and hormone concentrations were measured via passive drool. Results confirmed the hypothesis: high estradiol was associated with more externalizing behaviors, but only when cortisol was low and personality traits of disagreeableness and emotional instability were high. Further, these associations held when controlling for testosterone concentrations. These findings provide the first empirical evidence of a hypothalamic pituitary adrenal (HPA)×hypothalamic pituitary gonadal (HPG) axis interaction that extends the "dual hormone" hypothesis beyond testosterone.


Subject(s)
Adolescent Behavior/physiology , Aggression/physiology , Estradiol/metabolism , Gonads/metabolism , Hydrocortisone/metabolism , Hypothalamo-Hypophyseal System/metabolism , Pituitary-Adrenal System/metabolism , Self-Control/psychology , Adolescent , Adolescent Behavior/psychology , Aggression/psychology , Female , Humans , Male , Personality , Personality Disorders/metabolism , Personality Disorders/psychology , Saliva/chemistry , Social Dominance
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