Outcome of Treatment in Children With Chronic Viral Hepatitis C: A Single Centre Study.

Objective To review the efficacy of the combination of pegylated interferon-α 2b and ribavirin, and sofosbuvir and ribavirin in achieving sustained viral response (SVR) in chronic hepatitis C genotypes 1 and 3 in children. Methods A retrospective descriptive study was performed for children under 15 years of age treated for chronic hepatitis C at Pakistan Kidney and Liver Institute and Research Centre, Lahore, between 2018 and 2019. Demographic data and clinical information were collected. In addition, treatment outcome was assessed by SVR, defined as the absence of detectable viral RNA in blood after 24 weeks of initiation of treatment. Results A total of 30 children aged 15 years and below were included in this study. Sixteen of 30 children were males, and 14 were females. Of these 30 patients, four had hepatitis C virus (HCV) genotype 1, and 26 children had HCV genotype 3. The children with genotype 1 (a+b) were given the combination of ribavirin and pegylated interferon alfa-2b (Peg-IFN-α-2b). The remaining with HCV genotype 3 were given the combination of ribavirin and sofosbuvir for 24 weeks. Overall, 27 out of 30 (90%) children attained SVR at six months (100% children with genotype 1 and 88.4% children with genotype 3). Conclusion The combined therapy of ribavirin and sofosbuvir or Peg-IFN-α-2b and ribavirin is highly effective in treating chronic HCV infection in children.

Take a moment to apologize: How and why mindfulness affects apologies.

The current research examined whether mindfulness promotes offender apologies. In Study 1, we found a positive relation between trait mindfulness and one's disposition to apologize. In Study 2, we found a positive effect of a mindfulness intervention on state apology for a laboratory-induced transgression. In Study 3, an online mindfulness intervention was found to have a positive effect on apologetic (vs. nonapologetic) behavior for transgressors. In Study 4, we found preliminary support for reduced negative self-focused cognitions and emotions when testing a parallel mediation model. We also found support for negative self-focused, as well as positive other-focused, cognitions and emotions when testing a serial mediational model. Our findings are discussed within broader theoretical questions concerning the psychological factors that promote and prevent apologies and the role of mindfulness in constructive responses to transgressions from the perspective of offenders. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature.

INTRODUCTION AND OBJECTIVES: Surgical site infections (SSIs) represent a common and serious complication of all surgical interventions. Microorganisms are able to colonise sutures that are implanted in the skin, which is a causative factor of SSIs. Triclosan-coated sutures are antibacterial sutures aimed at reducing SSIs. Our objective is to update the existing literature by systematically reviewing available evidence to assess the effectiveness of triclosan-coated sutures in the prevention of SSIs. METHODS: A systematic review of EMBASE, MEDLINE, AMED (Allied and complementary medicine database) and CENTRAL was performed to identify full text randomised controlled trials (RCTs) on 31 May 2019. INTERVENTION: Triclosan-coated sutures versus non-triclosan-coated sutures. PRIMARY OUTCOME: Our primary outcome was the development of SSIs at 30 days postoperatively. A meta-analysis was performed using a fixed-effects model. RESULTS: Twenty-five RCTs were included involving 11 957 participants. Triclosan-coated sutures were used in 6008 participants and non triclosan-coated sutures were used in 5949. Triclosan-coated sutures significantly reduced the risk of SSIs at 30 days (relative risk 0.73, 95% CI 0.65 to 0.82). Further sensitivity analysis demonstrated that triclosan-coated sutures significantly reduced the risk of SSIs in both clean and contaminated surgery. CONCLUSION: Triclosan-coated sutures have been shown to significantly reduced the risk of SSIs when compared with standard sutures. This is in agreement with previous work in this area. This study represented the largest review to date in this area. This moderate quality evidence recommends the use of triclosan-coated sutures in order to reduce the risk of SSIs particularly in clean and contaminated surgical procedures. PROSPERO REGISTRATION NUMBER: CRD42014014856.

Competition affects food choice in women.

OBJECTIVE: To examine women's food choices after exposure to a threatening upward social comparison in an achievement situation. METHOD: Female university students performed three tasks in the presence of a confederate; for some, the situation was competitive and they were made to feel the confederate was likely to outperform them, whereas the remainder performed under noncompetitive circumstances. After completing the tasks, all participants chose a food to eat in a supposedly unrelated taste test. RESULTS: It was expected and found that participants in the high threat condition, in comparison with those in a low threat condition, would be highly motivated to restore their sense of self-worth by successfully competing in an area unrelated to the original inferiority and would, therefore, choose a lower calorie/more nutritious food. A secondary analysis revealed that it was primarily dieters whose food choices were affected by the threat. DISCUSSION: For dieters, competition by means of food choice can provide a means of restoring self-regard when self-esteem has been threatened in some other domain.