ABSTRACT
We present an unusual case of Listeria monocytogenes rhomboencephalitis in a young, healthy patient. Although L. monocytogenes meningitis is usually associated with immunodeficiency, rhomboencephalitis is more commonly seen in immunocompetent patients. The wide differential for rhomboencephalitis can create a diagnostic challenge. Without prompt pathogen identification and appropriate antibiotic regimen, L. monocytogenes central nervous system infections can be fatal. Cerebro-Spinal Fluid (CSF) Polymerase Chain Reaction (PCR) aided a prompt diagnosis and adjustment of therapy to achieve a good patient outcome.
Subject(s)
Immunocompetence , Listeria monocytogenes , Listeriosis , Humans , Listeria monocytogenes/isolation & purification , Listeriosis/diagnosis , Listeriosis/drug therapy , Anti-Bacterial Agents/therapeutic use , Male , Rhombencephalon/microbiology , Magnetic Resonance Imaging , Meningitis, Listeria/diagnosis , Meningitis, Listeria/drug therapy , Adult , Encephalitis/microbiology , Encephalitis/diagnosis , Polymerase Chain ReactionABSTRACT
Patient safety in healthcare remains a top priority. Learning from safety events is vital to move towards safer systems. As a result, reporting systems are recognised as the cornerstone of safety, especially in high-risk industries. However, in healthcare, the benefits of reporting systems in promoting learning remain contentious. Though the strengths of these systems, such as promoting a safety culture and providing information from near misses are noted, there are problems that mean learning is missed. Understanding the factors that both enable and act as barriers to learning from reporting is also important to consider. This review, considers the effectiveness of reporting systems in contributing to learning in healthcare.
Subject(s)
Learning , Patient Safety , Humans , Risk Management/methods , Medical Errors/prevention & control , Delivery of Health Care/standards , Safety ManagementABSTRACT
A newly qualified doctor's personal view, exploring how a struggling health service and changing medical education may impact the future role of the medical student. Medical curriculums and the health service might benefit from medical students taking an expanded role in error prevention, public health promotion and clinical responsibilities.
Subject(s)
Professional Role , State Medicine/organization & administration , Students, Medical , Health Education/organization & administration , Health Promotion/organization & administration , Health Workforce , Humans , United KingdomABSTRACT
When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.
