[Immuno-radiotherapy: A review of the rationale, recent clinical developments and future prospects]. / Immuno-radiothérapie : une revue du rationnel, développements cliniques récents et perspectives futures.

Thanks to the success of checkpoint inhibitors, immunotherapy now plays a major role in the management of a large number of solid tumors, while the number of indications continues to grow and new combinations could, in the near future, further modify treatment standards. However, the response rates of immunotherapies as monotherapy are modest and their use is increasingly considered in combination with other cancer treatments (chemotherapy, surgery, radiotherapy or certain targeted therapies). Combinations with radiotherapy seem particularly attractive because there is a strong experimental rationale linking part of the efficacy of ionizing radiation to an induced stimulation of both of the innate and adaptive response. Many early phases and a number of large randomized combination trials have published efficacy and safety results, while important trials are still ongoing and will provide answers in the near future. This short review recalls the experimental biological rationale for immuno-radiotherapy and highlights some of the fundamental directions being explored, then presents the clinical efficacy and safety results available to date, those expected in the near future, and finally outlines the outlook in this rapidly evolving field.

The influence of a pressure wavepacket's characteristics on its acoustic radiation.

Noise generation by flows is modeled using a pressure wavepacket to excite the acoustic medium via a boundary condition of the homogeneous wave equation. The pressure wavepacket is a generic representation of the flow unsteadiness, and is characterized by a space envelope of pseudo-Gaussian shape and by a subsonic phase velocity. The space modulation yields energy in the supersonic range of the wavenumber spectrum, which is directly responsible for sound radiation and directivity. The influence of the envelope's shape on the noise emission is studied analytically and numerically, using an acoustic efficiency defined as the ratio of the acoustic power generated by the wavepacket to that involved in the modeled flow. The methodology is also extended to the case of acoustic propagation in a uniformly moving medium, broadening possibilities toward practical flows where organized structures play a major role, such as co-flow around cruising jet, cavity, and turbulent boundary layer flows. The results of the acoustic efficiency show significant sound pressure levels, especially for asymmetric wavepackets radiating in a moving medium.