Sustainable preparation of AuAg alloy@AgBr Janus nanoparticles via dissipative self-assembly for photocatalysis.

We report a facile synthesis of cetyltrimethylammonium bromide (CTAB) templated AuAg alloy@AgBr Janus-nanoparticles (JNPs) using a non-conventional top-down approach with precise control over symmetry breaking. The addition of AgNO3 to a micellar solution of CTAB results in micelle-stabilized AgBr colloids having excess Ag+ at the interstitial sites of AgBr. AgBr colloids undergo weak self-assembly supported by inter-micellar interactions. The interfacial disturbance of self-assembled colloids via electrostatic adsorption of AuCl4- or Au(OH)4- at the micelle-AgBr interface downsizes the colloids. This is followed by the growth of the AuAg phase onto AgBr resulting in AuAg alloy@AgBr JNPs via different reduction pathways (photoreduction or chemical reduction) in the presence of ascorbic acid. The prepared JNPs act as efficient visible light photocatalysts for the degradation of aqueous rhodamine B. Interestingly, the trapping of holes favors the photocatalytic efficiency. Furthermore, the JNPs have shown proficiency in inhibiting the growth of both Gram-positive and Gram-negative bacteria as compared to the commercial antibiotic kanamycin, with a very low MIC value of ∼35 µg ml-1. In this way, a new single-pot strategy for the controlled preparation of photo-catalytically active and antimicrobial AuAg alloy@AgBr JNPs governed by dissipative self-assembly is reported for the first time.

Relationship between spirituality and depression among patients with malignant cancer at a selected tertiary care Institute - A study from North India.

Purpose: Depression is a major mental disorder and has drastic effects on people suffering from other terminal illnesses like cancer. Many patients struggling with chronic or fatal illnesses rely on spirituality to cope. Spirituality in Indian culture has always been a vital component in indigenous health systems.Objective: To determine the relationship between spirituality and depression among patients with cancer visiting a tertiary care institute of Uttarakhand State in northern India. Design: A descriptive cross-sectional survey.Sample: A total of 103 cancer patients visiting inpatient and outpatient departments of a selected tertiary care institute of Uttarakhand state of northern India. Methods: Participants were administered the socio-demographic proforma, Patient Health Questionnaire (PHQ-9) (Kroenke, Spitzer, and Williams, 2001), System of Belief Inventory (SBI-15R). Findings: The mean score of depression among cancer patients was 9.12±6.537 (CI, 7.84-10.39). Patients with high spirituality have minimal or no depression. We found a statistically significant negative correlation between depression and spirituality (r=-0.209, p=0.05).Conclusions: Health care professionals can incorporate spirituality in caring for cancer patients to develop a positive outlook on living despite the illness. Implications for Psychosocial Providers Or Policy: Establishing a spiritual support program as an integral part of a multidisciplinary approach can better cancer treatment in the Indian setting.