ABSTRACT
Dj-l is a protein encoded by PARK7 gene, a member of the peptidase C56 protein family. Defects in PARK7 gene may lead to autosomal recessive early-onset Parkinson ' s disease. Dj-1 is a multifunctional protein that acts as an active androgen receptor-mediated transcriptional regulator, a REDOX sensitive molecular chaperone, an oxidative stress sensor, and it also protects neurons from oxidative stress and cell death. In addition, DJ-1 is also associated with mitochondria, energy metabolism, mitochondrial homeostasis, mitophagy mitochondria-associated endoplasmic reticulum membranes and other life processes. However, the precise function of DJ-1 protein is not well understood. This paper reviews the effect, mechanism and molecular basis of DJ-1 protein in regulating mitochondrial function, and discusses its potential value in combination with clinical diseases. It has good timeliness, necessity, innovation and science, and also helps to provide new targets and ideas for clinical drug development.
ABSTRACT
Comprehensive assessment on urban ecological system is one of important issues for regional sustainable development research. Urban eco-efficiency is the effective tool to integrate sustainabable strategies into the development planning and management initiatives, which expresses the relationship of inputs of ecological impact and outputs of social welfare. An evaluation model of urban sustainability based on eco-efficiency was proposed by integrating Ecological Footprint model and Human Development Index. Using this model, a case study of Xiamen City was carried out using the statistical data from 2000 to 2006. There is a fluctuation of ecoefficiency which showed a steady increase first, then a sharp decline and a marginal increase towards the end. During 2000-2006, the per-capita ecological footprint increases from 4.279 hm2 to 5.462 hm2; and the Human Development Index increases from 0.831 to 0.896; thus the eco-efficiency, resource efficiency and environmental efficiency declines by 15.5%, 15.7% and 15.3% respectively. Xiamen experiences sustainability hypo-increasing phase first, sustainability increasing phase secondly, then sustainability decreasing phase, and sustainability increasing phase in the end. On the whole, the urban sustainability shows a decreasing trend.