Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters











Database
Language
Publication year range
1.
J Nutr ; 154(10): 3133-3143, 2024 Oct.
Article in English | MEDLINE | ID: mdl-39019165

ABSTRACT

BACKGROUND: Evidence shows that CD4+ T cells are altered in obesity and play a significant role in the systemic inflammation in adults with the disease. OBJECTIVES: Because the profile of these cells is poorly understood in the pediatric population, this study aims to investigate the profile of CD4+ T lymphocytes and the plasma levels of cytokines in this population. METHODS: Using flow cytometry, we compared the expression profile of lymphocyte markers, master transcription factors, cytokines, and molecules involved in the regulation of the immune response in CD4+ T cells from children and adolescents with obesity (OB group, n = 20) with those with eutrophy group (EU group, n = 16). Plasma levels of cytokines in both groups were determined by cytometric bead array (CBA). RESULTS: The OB group presents a lower frequency of CD3+ T cells, as well as a decreased frequency of CD4+ T cells expressing CD28, IL-4, and FOXP3, but an increased frequency of CD4+IL-17A+ cells compared with the EU group. The frequency of CD28 is increased in Th2 and Treg cells in the OB group, whereas CTLA-4 is decreased in all subpopulations compared with the EU group. Furthermore, Th2, Th17, and Treg profiles can differentiate the EU and OB groups. IL-10 plasma levels are reduced in the OB group and negatively correlated with adiposity and inflammatory parameters. CONCLUSIONS: CD4+ T cells have an altered pattern of expression in children and adolescents with obesity, contributing to the inflammatory state and clinical characteristics of these patients.


Subject(s)
CD4-Positive T-Lymphocytes , Cytokines , Humans , Child , Adolescent , Female , Male , CD4-Positive T-Lymphocytes/immunology , Cytokines/blood , Cytokines/metabolism , Obesity/immunology , T-Lymphocyte Subsets/immunology , Pediatric Obesity/immunology , Forkhead Transcription Factors/metabolism , Forkhead Transcription Factors/genetics , CTLA-4 Antigen/metabolism , Interleukin-4/blood , CD28 Antigens/metabolism
SELECTION OF CITATIONS
SEARCH DETAIL