Determining the acceptability of testing contacts of confirmed COVID-19 cases to improve secondary case ascertainment.

BACKGROUND: UK asymptomatic contacts of confirmed COVID-19 cases are not routinely tested for SARS-CoV-2. Testing contacts may improve case ascertainment and reduce onward transmission. This study investigated the acceptability of SARS-CoV-2 testing among contacts of confirmed cases as an integral part of the contact-tracing process. METHODS: A cross-sectional descriptive survey of case contacts was conducted in the UK. All contacts who completed a telephone call with the NHS Test and Trace Agile Lighthouse team were eligible for inclusion and were offered a molecular test. Consenting participants were sent a self-swab kit. RESULTS: Of the 1523 individuals contacted, 602 (39.5%) accepted the test offer. Of the 240 (39.9%) samples returned for testing, 16.3% tested polymerase chain reaction-positive for SARS-CoV-2.Most individuals who declined with a reason (638/905; 70.5%) reported they had already taken or booked a SARS-CoV-2 test, or were part of a testing programme. Matched laboratory records confirmed 73.1% of those who declined were tested by another route. CONCLUSIONS: Most case contacts were tested, either through arranging a test by themselves or by accepting the study offer. Results demonstrate high acceptability, with substantial test positivity, indicating that there is public health benefit in offering tests to contacts as a routine part of the contact-tracing process.

Meningococcal Disease in Northern Ireland - Past, Present & Future: MeningoNI Forum.

Meningococcal disease has had devastating consequences in Northern Ireland since its first description locally in 1859. The incidence of this disease has significantly declined in recent years, however it is important to understand reasons for this changing epidemiology and to acknowledge the diagnostic and clinical management developments that have been made locally. This review aims to examine the changing face of this disease in Northern Ireland over the years, with particular reference to local disease prevention, epidemiology, diagnosis, clinical treatment and management, post-disease sequelae and the role of meningitis charities locally, in terms of patient support and research.

Spotlight on measles 2010: ongoing measles outbreak in Northern Ireland following an imported case, September-October 2010.

We report an ongoing outbreak of measles with five laboratory-confirmed and four epidemiologically linked cases in Northern Ireland as at 26 October 2010. The index case was an unvaccinated non-Northern Ireland resident with subsequent genotyping suggesting that infection originated in the usual country of residence of this case. Confirmed cases include one patient with a history of two measles-mumps-rubella vaccine doses.

Molecular evidence of tick-transmitted infections in dogs and cats in the United Kingdom.

PCR analysis was used to determine the prevalence of tick-transmitted infections in 120 systemically ill dogs and 60 cats recruited over a period of three months from 52 veterinary practices in the UK. The animals had not travelled outside the UK and had one or more of the following clinical criteria: acute or recurrent pyrexia, anaemia and/or thrombocytopenia, polyarthritis/muscle pain, splenomegaly/lymphadenopathy, and intraocular inflammation with systemic signs. Blood samples from the animals were tested for the presence of DNA from Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum by using simple PCR targeting. B. burgdorferi sensu lato was detected in five dogs and two cats, and A. phagocytophilum was detected in one dog and one cat. These results provide the first molecular evidence of naturally occurring B. burgdorferi sensu lato infection in cats in the UK and confirm that A. phagocytophilum infection is present in cats. There were no statistically significant associations between the infections and the clinical signs shown by the dogs and cats.

Rapid response and strict control measures can contain a hospital outbreak of Norwalk-like virus.

Norwalk-like viruses (NLVs) are a major cause of sporadic gastroenteritis in the community and of large outbreaks of gastroenteritis in hospitals and other institutions. In January 2001, 38 staff and 20 patients on an acute elderly care ward became ill in an outbreak of gastrointestinal infection. Using reverse transcription polymerase chain reaction (RT-PCR) the causative agent was identified as NLV. No link was found between particular foods eaten and illness. At various times in the course of the outbreak a number of wards were implicated, but in hindsight the outbreak was confined to one ward. A prompt and rigorous response was successful in containing the spread of NLV infection to just one ward and stopping it in a few days.

Mumps outbreak among young people in Northern Ireland.

An outbreak of mumps occurred in the Mid-Ulster area of Northern Ireland between 1st November 1999 and 31st August 2000, with 729 cases notified. Salivary test results were obtained for 430 (59%) reported cases, of which 332 (77%) were positive for mumps IgM antibody. Three hundred and sixteen (95.2%) of these confirmed cases were in the age range 9 to 19. One hundred and eighty-four (55.4%) confirmed cases had received one dose of MMR (measles, mumps and rubella) vaccine, but only 3 (0.9%) confirmed cases had received 2 doses of MMR. The low incidence of mumps among children who had received two doses of MMR illustrates the importance of the second dose of MMR for full protection.

Solar imaging with a segmented adaptive mirror.

A 19-segment adaptive-mirror system is currently being used on the Sacramento Peak 76-cm Tower Telescope to remove wave-front distortions resulting from atmospheric turbulence. The system has proven to be capable of substantially improving the quality of an image, at times achieving 0.33-arcsec resolution in visible wavelengths under 1-3-arcsec seeing conditions. An improvement in resolution seems to occur across a large field of view that is, at times, 30 arcsec in diameter.

A programmable analog neural network processor.

An analog neural network breadboard consisting of 256 neurons and 2048 programmable synaptic weights of 5 bits each is constructed and tested. The heart of the processor is an array of custom-programmable synapse (resistor) chips on a reconfigurable neuron board. The analog bandwidth of the system is 90 kHz. The breadboard is used to demonstrate the application of neural network learning to the problem of real-time adaptive mirror control. The processor control is 21 actuators of an adaptive mirror with a step-response setting time of 5 ms. The demonstration verified that it is possible to modify the control law of the high-speed analog loop using neural network training without stopping the control loop.

An outbreak of puerperal fever caused by group C streptococci.

Between 19 February and 18 April 1987, 33 confirmed cases of puerperal fever caused by Streptococcus equisimilis serotype T204 occurred at three hospitals in and around Chelmsford. Most of the cases (70%) occurred on one ward, in which toilet seats and a shower are believed to have aided transmission, although insufficient data were obtained to exclude a role for person-to-person spread. Possession of M-protein antigen was demonstrated in the outbreak strain.

Quantitative simulation of image correction for astronomy with a segmented active mirror.

Correction by active mirror systems of image distortion due to atmospheric turbulence promises to improve the quality of ground-based astronomical observations. Although the ideal of fully correcting average-to-poor seeing to the diffraction limit of a large telescope cannot be easily realized with current technology, it has been demonstrated that partial correction of severe seeing disturbances can significantly improve image resolution. This paper describes a computer simulation of partial seeing correction by the Lockheed Active Mirror. Quantitative evaluation of the effects of partial correction on simulated wavefronts indicates that, even with a modest number of mirror actuators, one can achieve a diffraction-limited image superimposed on a background of scattered light.

Single photon x-ray detection with a CCD image sensor.

Individual x rays of 5.9 and 22.4 keV have been detected and energy analyzed in single pixels of a CCD image sensor. The results indicate the CCD operates as an array of tiny Si solid state detectors providing both high spatial resolution and x-ray energy discrimination. These devices will prove useful sensors at the focus of future x-ray telescopes.