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1.
Food Funct ; 14(22): 10163-10176, 2023 Nov 13.
Article in English | MEDLINE | ID: mdl-37902089

ABSTRACT

(Poly)phenol (PP)-rich blackcurrant (BC) extracts reduce postprandial glucose concentrations. Combinations with other fruit (poly)phenols and fruit fibre may enhance the effect. This study investigated the acute effects of combinations of BC extracts, high (H-BC) and low (L-BC) (poly)phenol concentrations, sweet orange extracts (SO) and fibre-rich orange pulp (F) in reducing postprandial glycaemia. In two randomised, double-blind, crossover design studies, healthy participants consumed seven types of 200 mL beverages: in the GLU-FX trial, H-BC (1600 mg PP); L-BC (800 mg PP); SO (800 mg PP); BC + SO (1600 mg PP) or CON (placebo); in the GLU-MIX trial, BC + F (800 mg PP), F (1.5 g fibre), or CON2 (placebo), immediately followed by consumption of 75 g available carbohydrate (starch and sugars). Blood was sampled at baseline and postprandially to measure changes in glucose, insulin, and gut hormones; appetite changes were assessed by visual analogue scales and, in GLU-MIX, ad libitum food intake and cognitive function were assessed. Twenty-nine and thirty-seven adults completed GLU-FX and GLU-MIX, respectively. L-BC reduced early postprandial glycaemia (0-30 min) with no differences in glucose incremental Cmax or total glycaemic response. No significant effect was observed following other drinks relative to CON. L-BC and H-BC drinks inhibited insulin secretion up to 30 min and GIP up to 120 min. In GLU-MIX, BC + F improved some indicators of cognitive function but not all. Measures of appetite were unaffected. The impact of (poly)phenol-rich BC extracts on total postprandial glycaemia in healthy participants was minimal and not enhanced when administered in combination with an orange (poly)phenol extract or orange pulp. Clinical Trials registered at https://www.clinicaltrials.gov: NCT03184064 (GLU-FX) and NCT03572296 (GLU-MIX).


Subject(s)
Citrus , Gastrointestinal Hormones , Humans , Adult , Appetite , Blood Glucose , Phenols/pharmacology , Phenol/pharmacology , Glucose/pharmacology , Dietary Fiber/pharmacology , Insulin , Cognition , Postprandial Period , Cross-Over Studies , Randomized Controlled Trials as Topic
2.
Ann Acad Med Stetin ; 58(1): 18-22, 2012.
Article in Polish | MEDLINE | ID: mdl-23547389

ABSTRACT

Bowel obstruction caused by a gallstone is a rare pathology in the abdomen. The high mortality associated with this condition has prompted the authors to present their experience over the past two years against the background of published case reports. This paper presents three different ways of management of gallstone ileus: enterolithotomy; two-stage surgery--enterolithotomy followed by cholecystectomy; one-stage surgery--enterolithotomy combined with cholecystectomy and fistula repair. The authors report on a case which was successfully managed with enterolithotomy only and discuss arguments in favor of each procedure. Enterolithotomy appears to be the safest approach in gallstone ileus, leaving time to qualify the patient for further surgery on the basis of clinical status and symptoms.


Subject(s)
Gallstones/complications , Gallstones/surgery , Ileus/etiology , Ileus/surgery , Intestine, Small/surgery , Aged , Cholecystectomy , Digestive System Surgical Procedures , Female , Gallstones/diagnosis , Humans , Ileus/diagnosis , Intestinal Fistula/diagnosis , Intestinal Fistula/surgery , Male , Middle Aged
3.
Ann Acad Med Stetin ; 58(1): 78-83, 2012.
Article in Polish | MEDLINE | ID: mdl-23547400

ABSTRACT

The scientific and educational activity of the West Pomeranian Branch of the Polish Association of Surgeons during its 60 years of existence is presented on occasion of the 120 anniversary of the Polish Association of Surgeons. We present the profile of Professor Seweryn Wiechowski, the first head of the Department of Cardiosurgery in Szczecin, as well as his educational and research contributions and role he played in the development of general surgery and cardiosurgery in West Pomeranian. Professor Seweryn Wiechowski, acting as president of the Polish Association of Surgeons in 1993-1995 organized the 57th Congress of the Polish Association of Surgeons in September 6-9, 1995 held for the first time in Szczecin.


Subject(s)
General Surgery/history , Societies, Medical/history , History, 20th Century , History, 21st Century , Poland
4.
Ann Acad Med Stetin ; 58(2): 61-5, 2012.
Article in Polish | MEDLINE | ID: mdl-23767184

ABSTRACT

On occasion of the 120th anniversary of the founding of the Polish Association of Surgeons, we present the scientific and educative activities of the West Pomeranian Section of the Association during its 60 years of existence. The aim of this work is to present the profile of Prof. Tomasz Grodzki, one of the founders of the Polish Society of Cardiothoracic Surgeons and head of the Department of Thoracic Surgery at the hospital in Szczecin-Zdunowo. Attention is devoted to his educative and scientific contributions and to the role played by Prof. Grodzki in the development of thoracic surgery in the province of West Pomerania. In cooperation with the Department of Cardiosurgery, Second Clinical Hospital in Szczecin, Professor Grodzki, as head of the Thoracic Surgery Ward at the hospital in Szczecin-Zdunowo, organized the First Founding Congress of the Polish Society of Cardiothoracic Surgeons in April 26-28, 2002.


Subject(s)
Societies, Medical/history , Thoracic Surgery/history , History, 20th Century , History, 21st Century , Poland , Societies, Medical/organization & administration , Thoracic Surgery/organization & administration
5.
Ann Acad Med Stetin ; 57(2): 39-42, 2011.
Article in Polish | MEDLINE | ID: mdl-23002667

ABSTRACT

A gastrointestinal fistula is a late complication of peptic ulcer disease and forms when gastric resection is inadequate or vagotomy is incomplete or not performed. Such cases are extremely rare and are occasionally reported in the literature. We present a patient with a gastrocolic fistula which developed 7 years after partial gastrectomy due to pyloric stenosis as a sequella of peptic ulcer. Nonspecific clinical symptoms and ambiguous radiographic findings delayed the diagnosis of gastrocolic fistula. The patient was operated; "en bloc" resection of the fistula with partial resection of the transverse colon and stomach supplemented with truncal vagotomy was done. The possible cause of recurrence of peptic ulcer in this patient was that vagotomy was not done during the first surgical intervention. Thus, the gastrocolic fistula became a late complication of the recurrence of peptic ulcer. Diagnostic difficulties in gastrocolic fistulas are presented and surgical management of this complication is discussed.


Subject(s)
Colonic Diseases/diagnosis , Gastrectomy/adverse effects , Gastric Fistula/diagnosis , Intestinal Fistula/diagnosis , Peptic Ulcer/surgery , Colonic Diseases/etiology , Colonic Diseases/surgery , Gastric Fistula/etiology , Gastric Fistula/surgery , Humans , Intestinal Fistula/etiology , Intestinal Fistula/surgery , Male , Middle Aged , Recurrence
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