Real-time tissue differentiation based on optical emission spectroscopy for guided electrosurgical tumor resection.

Complete surgical removal of cancer tissue with effective preservation of healthy tissue is one of the most important challenges in modern oncology. We present a method for real-time, in situ differentiation of tissue based on optical emission spectroscopy (OES) performed during electrosurgery not requiring any biomarkers, additional light sources or other excitation processes. The analysis of the optical emission spectra, enables the differentiation of healthy and tumorous tissue. By using multi-class support vector machine (SVM) algorithms, distinguishing between tumor types also seems to be possible. Due to its fast reaction time (0.05s) the method can be used for real-time navigation helping the surgeon achieve complete resection. The system's easy realization has been proven by successful integration in a commercial electro surgical unit (ESU). In a first step the method was verified by using ex vivo tissue samples. The histological analysis confirmed, 95% of correctly classified tissue types.

Implantable impedance plethysmography.

We demonstrate by theory, as well as by ex vivo and in vivo measurements that impedance plethysmography, applied extravascularly directly on large arteries, is a viable method for monitoring various cardiovascular parameters, such as blood pressure, with high accuracy. The sensor is designed as an implant to monitor cardiac events and arteriosclerotic progression over the long term.

Highly compact imaging using Bessel beams generated by ultraminiaturized multi-micro-axicon systems.

Employing Bessel beams in imaging takes advantage of their self-reconstructing properties to achieve small focal points while maintaining a large depth of focus. Bessel beams are efficiently generated using axicons, and their utility in scanning imaging systems, such as optical coherence tomography (OCT), has been demonstrated. As these systems are miniaturized to allow, for example, endoscopic implementations, micro-axicons are required to assure the maintenance of a large depth of focus. We demonstrate here the design, fabrication, and application of molded micro-axicons for use in silicon-based micro-optical benches. It is shown that arrangements of multiple convex and concave axicons may be implemented to optimize the depth of focus in a miniaturized OCT system, using a telescopic optical arrangement of considerably shorter optical system length than that achievable with classical micro-optics.