1.
Aust Vet J
; 53(4): 176-80, 1977 Apr.
Article
in English
| MEDLINE
| ID: mdl-869813
ABSTRACT
Babesia argentina was repeatedly exposed to imidocarb by transmitting parasites from infected ticks in a series of 4 groups of nonsplenectomised calves that had been treated prophylactically at 2 mg/kg. As the number of exposures to imidocarb increased, the parasites more readily infected the treated calves, indicating increased tolerance to the drug. Tests comparing parasites not previously exposed to imidocarb with those exposed 4 times showed that a dose of 3 mg/kg imidocarb completely cured subclinical infections with non-exposed, but not exposed, parasites; a dose of 1 mg/kg controlled acute infections with either nonexposed or exposed parasites; and the virulence of the parasite was apparently unaffected by the exposures.
Subject(s)
Babesia/drug effects , Babesiosis/prevention & control , Carbanilides/pharmacology , Cattle Diseases/prevention & control , Imidocarb/pharmacology , Animals , Babesia/pathogenicity , Babesiosis/drug therapy , Cattle , Cattle Diseases/drug therapy , Drug Tolerance , Imidocarb/therapeutic use , Ticks/parasitology , Virulence/drug effects
2.
Aust Vet J
; 52(11): 543, 1976 Nov.
Article
in English
| MEDLINE
| ID: mdl-1016162