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Int J Pharm ; 517(1-2): 50-57, 2017 Jan 30.
Article in English | MEDLINE | ID: mdl-27915007

ABSTRACT

Quercetin has been identified as a promising compound with a neuroprotective potential against age-related neurodegenerative diseases such as Alzheimer's disease (AD). Nevertheless, the clinical application of quercetin is hampered by its low oral bioavailability. The aim of this work was to evaluate the capability of nanoencapsulated quercetin in zein nanoparticles (NPQ), that significantly improves the oral absorption and bioavailability of the flavonoid, as potential oral treatment for AD. For this purpose, SAMP8 mice were orally treated for two months with either NPQ (25mg/kg every 48h) or a solution of quercetin (Q; 25mg/kg daily). NPQ displayed a size of 260nm and a payload of about 70µg/mg. For Q, no significant effects were observed in animals. On the contrary, the oral administration of NPQ improved the cognition and memory impairments characteristics of SAMP8 mice. These observations appeared to be related with a decreased expression of the hippocampal astrocyte marker GFAP. Furthermore, significant levels of quercetin were quantified in the brain of mice treated with nanoparticles. These findings highlight the potential of zein nanoparticles to promote the oral absorption of quercetin as well as the therapeutic potential of this flavonoid in AD pathogenesis.


Subject(s)
Alzheimer Disease/drug therapy , Behavior, Animal/drug effects , Drug Carriers/chemistry , Motor Activity/drug effects , Neuroprotective Agents/therapeutic use , Quercetin/therapeutic use , 2-Hydroxypropyl-beta-cyclodextrin , Administration, Oral , Alzheimer Disease/psychology , Animals , Brain/drug effects , Brain/metabolism , Disease Models, Animal , Male , Maze Learning/drug effects , Mice, Inbred Strains , Neuroprotective Agents/administration & dosage , Neuroprotective Agents/pharmacokinetics , Particle Size , Quercetin/administration & dosage , Quercetin/pharmacokinetics , Rotarod Performance Test , Zein/chemistry , beta-Cyclodextrins/chemistry
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