Response of microbial community in the soil of halophyte after contamination with tetrabromobisphenol A.

Coastal wetlands are subjected to increasing tetrabromobisphenol A (TBBPA) pollution, whereas knowledge of TBBPA degradation in marine environments is lacking. The changes of bacterial communities in TBBPA-polluted soil covered with halophytes were investigated. TBBPA could be degraded in the halophyte-covered saline-alkali soil in a microcosm experiment. Higher TBBPA removal occurred in the soil of Kandelia obovata compared with soils covered with Suaeda australis and Phragmites australis within 56 days of cultivation. The rhizosphere soils of S. australis, P. australis, and K. obovata mainly involved the classes of Bacteroidia, Gammaproteobacteria, Alphaproteobacteria, and Anaerolineae. Additionally, manganese oxidation, aerobic anoxygenic phototrophy, and fermentation functions were higher in the rhizosphere soil of K. obovata after TBBPA addition. This study supports that using suitable local halophytic plants is a promising approach for degrading TBBPA-contaminated coastal soil.

Research on core strength training for volleyball players / Pesquisa sobre o treinamento do core dos jogadores de voleibol / Investigación sobre el entrenamiento del core de los jugadores de voleibol

ABSTRACT Introduction: Modern exercise physiology theory states that abdominal core muscle strength plays a very important role in the completion of athletes' motor skills; the specific performance is to stabilize the athlete's center of gravity, the source of explosion and power transmission beyond his center of control. Objective: Verify the effect of an experimental training methods on the muscular strength of the abdominal core in volleyball athletes. Methods: 24 athletes were divided into an experimental group and a control group, in order to ensure that the baseline indicators of the two groups before the experiment did not show significant comparison, using independent sample t-test and paired sample t-test. Results: The average number of sit-ups of the two groups of students was 58.15 and 70.52n, respectively, the five baseline indicators of stability of the two groups were all significant, and the strength training methods in the experimental group were better than those in the control group. Conclusion: The presented experimental method helps to improve the success rate in athlete's jump. The core strength training methods used in the experimental group in jumping were superior to the traditional training methods used in the control group. Level of Evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: A moderna teoria da fisiologia do exercício afirma que a força muscular do core desempenha um papel muito importante na conclusão das habilidades motoras dos atletas; o desempenho específico é estabilizar o centro de gravidade do atleta, a fonte de explosão e transmissão de potência além do seu centro de controle. Objetivo: Verificar o efeito dos métodos de um treinamento experimental sobre a força muscular do core em atletas de voleibol. Métodos: 24 atletas foram divididos em grupo experimental e grupo de controle, a fim de garantir que os indicadores basais dos dois grupos antes do experimento não apresentassem comparação significativa, usando teste t de amostra independente e teste t de amostra pareada. Resultados: O número médio de sit-ups dos dois grupos de estudantes foi de 58,15 e 70,52n, respectivamente, os cinco indicadores básicos de estabilidade dos dois grupos foram todos significativos, e os métodos de treinamento da força no grupo experimental foram melhores do que os do grupo controle. Conclusão: O método experimental apresentada ajuda a melhorar a taxa de sucesso no salto do atleta. Os métodos de treinamento da força do core usados no grupo experimental em salto foram superiores aos métodos tradicionais de treinamento usados no grupo de controle. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: La teoría moderna de la fisiología del ejercicio afirma que la fuerza muscular del core desempeña un papel muy importante en la realización de las habilidades motrices de los atletas; la actuación específica consiste en estabilizar el centro de gravedad del atleta, la fuente de explosión y la transmisión de potencia más allá de su centro de control. Objetivo: Verificar el efecto de los métodos de un entrenamiento experimental sobre la fuerza muscular del core en atletas de voleibol. Métodos: 24 atletas fueron divididos en un grupo experimental y un grupo de control, con el fin de garantizar que los indicadores basales de los dos grupos antes del experimento no mostraran una comparación significativa, utilizando la prueba t de muestras independientes y la prueba t de muestras emparejadas. Resultados: El número medio de sentadillas de los dos grupos de estudiantes fue de 58,15 y 70,52n, respectivamente, los cinco indicadores de estabilidad de referencia de los dos grupos fueron todos significativos, y los métodos de entrenamiento de fuerza del grupo experimental fueron mejores que los del grupo de control. Conclusión: El método experimental presentado ayuda a mejorar la tasa de éxito en el salto del atleta. Los métodos de entrenamiento del core utilizados en el grupo experimental en los saltos fueron superiores a los métodos de entrenamiento tradicionales utilizados en el grupo de control. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity.

A series of novel tetrahydropyrazolopyridone derivatives containing 1,3,4-triazole, triazolylmethyl, and partially saturated heterocyclic moieties as P2 binding element was designed, synthesized, and evaluated in vitro for anticoagulant activity in human and rabbit plasma. All compounds showed moderate to significant potency, and compounds 15b, 15c, 20b, 20c, and 22b were further examined for their inhibitory activity against human FXa in vitro. While compounds 15c and 22b were tested for rat venous thrombosis in vivo. The most promising compound 15c, with an IC50 (FXa) value of 0.14µM and 98% inhibition rate, warranted further investigation as an FXa inhibitor.

Design, synthesis, and structure-activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 binding element.

Four series of novel and potent FXa inhibitors possessing the 1,2,4-triazole moiety and pyrrole moiety as P2 binding element and dihydroimidazole/tetrahydropyrimidine groups as P4 binding element were designed, synthesized, and evaluated for their anticoagulant activity in human and rabbit plasma in vitro. Most compounds showed moderate to excellent activity. Compounds 14a, 16, 18c, 26c, 35a, and 35b were further examined for their inhibition activity against human FXa in vitro and rat venous thrombosis in vivo. The most promising compound 14a, with an IC50 (FXa) value of 0.15µM and 99% inhibition rate, was identified for further evaluation as an FXa inhibitor.