ABSTRACT
Background: The COVID-19 pandemic poses a significant global health threat, characterized by high morbidity, severity, and the emergence of concerning variants. Latin America has been greatly affected, with high infection and mortality rates. Vaccination plays a crucial role in mitigating severe disease and controlling the pandemic. This study aims to assess the effectiveness of COVID-19 vaccines in preventing SARS-CoV-2 severe acute respiratory infections (SARI) in hospitalized vaccination target groups in Ecuador. Methods: This is a test-negative design study. We used data reported through sentinel surveillance of SARI between May 2021 and March 2022 in Ecuador. Patients with case criteria of SARI and hospitalized for a minimum of 24 hours were included in the study. Cases were defined as patients with SARI with a positive RT-qPCR test for SARS-CoV-2 and controls were those with a negative result. Information on vaccination status was obtained from the national vaccination registry, a valid dose of vaccination was considered when it was administered at least 14 days prior to symptom onset. Vaccine effectiveness (VE) (1-OR/OR) was calculated using a logistic regression. Results: A total of 1,277 patients were included in the analysis of VE. The adjusted vaccine effectiveness (aVE) in preventing hospitalization, adjusted for sex, age group, presence of one or more comorbidities, and period of the predominance of the omicron variant, was 44.5% for the partial primary schedule, 74.7% for the complete primary schedule, and 79.9% for the complete primary schedule plus booster doses. The aVE in avoiding ICU admissions was close to 80% with both the complete primary schedule and the booster doses, and in avoiding deaths, the aVE was 89% and 98%, respectively. Conclusions: In Ecuador, COVID-19 vaccination prevents hospitalizations, ICU admissions, and deaths. The effectiveness of the vaccines improves with more doses, offering increased protection across all age groups.
ABSTRACT
El objetivo fundamental del estudio fue determinar la prevalencia de malnutrición en ancianos residentes en 7 hogares de Quito subsidiados por el Ministerio de Bienestar Social, para lograrlo se realizó un estudio de corte transversal en el que se investigaron 239 ancianos, residentes en los hogares en los que se permitió hacer el estudio, se aplicaron: un cuestionario buscando factores demográficos, socioeconómico, estado de salud general y bucal, autonomía funcional, se valoró el estado nutricional mediante medidas antropométricas: peso, talla, circunferencia braquial y pliegues del tríceps, exámenes de hemoglobina y albúmina, y recordatorio dietético de las 24 horas anteriores. Los criterios de inclusión para el estudio, fueron las personas de más de 60 años...
