ABSTRACT
Background: A lung cancer screening project was conducted by attracting active participation to evaluate its feasibility and effectiveness in areas with poor basic medical education. Methods: This project entailed a prospective, single-arm study which was conducted by means of delivering a lecture on lung cancer at the Honghe Lung Cancer Medical Center to attract public attention and attendance from 28 November 2020 to 21 December 2021. A questionnaire comprising 7 high-risk factors was completed by participants to identify high-risk individuals for further chest low-dose computed tomography examination. Non calcified nodules with a diameter ≥5 mm were deemed positive nodules. The positive nodules were discussed by a multidisciplinary team and treatment suggestions were given. Finally, we analyzed participant information, examination adherence, lung cancer detection rate, and staging. Results: A total of 6,121 individuals were attracted to the project, and 5,925 (96.8%) agreed to participate. Of these, 5,889 (99.4%) completed the survey, with 4,627 (78.6%) in the high-risk group and 1,262 (21.4%) in the non-high-risk group. The proportion of males in the high-risk group was higher than that in the non-high-risk group, and the difference was statistically significant among those aged 40-49 years, 50-59, years and 60-69 years; P<0.01. In the high-risk population, 4,536 (98.0%) of participants adhered to examination, among whom 2,007 (44.2%) with positive nodules, 1,220 (26.9%) with negative nodules, and 1,309 (28.9%) without nodules showed statistical differences in age; P<0.01. The detection rate of lung cancer was 2.2% (99/4,536); 94.0% (93/99) of whom were stage 0-I patients. Conclusions: A health lecture-based approach to improving public participation in regions with poor health education is likely to be effective in promoting the early detection of lung cancer.
ABSTRACT
PURPOSE: We assessed the differences between 2-dimensional (2D) and 3-dimensional (3D) sonography (US) in evaluating fetal malformations. METHODS: Both 2D US and 3D US were used to examine pregnant women whose fetuses had malformations. The diagnostic information provided by the modalities was evaluated and compared. RESULTS: A total of 62 malformations were confirmed by postnatal or postmortem follow-up in 41 fetuses of 40 pregnant women. 2D US made a definite and correct diagnosis of 49 malformations (79%), whereas 3D US definitely diagnosed 58 malformations (94%) (p < 0.01). 3D US definitely diagnosed all the abnormalities in 38 fetuses (93%), whereas 2D US did so in only 32 fetuses (78%) (p < 0.05). In 35 (60%) of the 58 malformations revealed by both 3D US and 2D US, the former provided more diagnostic information than the latter. 3D US was particularly superior to 2D US in evaluating fetal malformations of the cranium and face, spine and extremities, and body surface. CONCLUSIONS: In comparison with 2D US, 3D US improves the diagnostic capability by offering more diagnostic information in evaluating fetal malformations, particularly in displaying fetal malformations of the cranium and face, spine and extremities, and body surface. 3D US is a valuable adjunct to 2D US in prenatal diagnosis.