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1.
Int J Eat Disord ; 2024 Oct 04.
Article in English | MEDLINE | ID: mdl-39364628

ABSTRACT

OBJECTIVE: The present longitudinal study examined sex-specific, symptom-level relationships among emotion regulation (ER), interpersonal problems (IP), and eating disorder (ED) psychopathology in a large sample of Chinese adolescents. METHOD: Data were from a project with four waves of data collection (N = 1540; 710 boys and 830 girls) at 6-month intervals over 18 months. Questionnaires assessed ED psychopathology, ER, and IP at each wave of data collection. Longitudinal network analyses were conducted separately for boys and girls. Sex differences in the network structures were also examined. RESULTS: The results revealed pronounced heterogeneity in the presentation of ED psychopathology, ER, and IP across Chinese adolescent boys and girls longitudinally and intra-individually. For example, weight/shape preoccupation in ED psychopathology and awareness in ER emerged as important nodes in the temporal network for boys. However, weight/shape preoccupation and dissatisfaction in ED psychopathology were identified as the most important nodes in the temporal network for girls. Regarding bridge strength, awareness in ER emerged as the node with the highest connectivity in the temporal network for boys. At the same time, weight/shape dissatisfaction in ED psychopathology was the node with the highest connectivity for girls. DISCUSSION: The current study extended network theory to better understand the longitudinal interplay among ER, IP, and ED psychopathology in Chinese adolescents and their sex differences in the importance of symptoms. Such insights may pave the way for developing targeted prevention and treatment strategies for adolescent boys and girls in China.

2.
Body Image ; 51: 101789, 2024 Sep 12.
Article in English | MEDLINE | ID: mdl-39270474

ABSTRACT

Body image flexibility has shown robust negative associations with body dissatisfaction. However, research in this area is confined to cross-sectional studies on adults in Western cultural contexts. Responding to these gaps and the unique cultural nuances and increasing prevalence estimates of body dissatisfaction in China, we examined the bi-directional nature of body image flexibility and body fat and muscularity dissatisfaction in Chinese adolescent boys and girls (N = 1381, 57.3 % girls) at two points over 18 months (Wave [W] 1=baseline, W2=18 months later). We also explored sex differences in longitudinal models. In boys, higher W1 body image flexibility was associated with lower W2 body fat dissatisfaction, and higher W1 body fat dissatisfaction was associated with lower W2 body image flexibility. Null prospective associations between body image flexibility and muscularity dissatisfaction were identified in boys. In girls, higher W1 body fat and muscularity body dissatisfaction were associated with lower W2 body image flexibility. Higher W1 body image flexibility was associated with lower W2 body fat and muscularity dissatisfaction in girls. We found no significant sex differences in the models. Findings advance a multicultural understanding of the temporal and bi-directional links between body image flexibility and body fat and muscularity dissatisfaction in Chinese adolescents.

3.
Huan Jing Ke Xue ; 45(9): 5086-5096, 2024 Sep 08.
Article in Chinese | MEDLINE | ID: mdl-39323127

ABSTRACT

Since 2010, the Chinese economy has transitioned from a high-speed growth model to a high-quality development model. During this period, the logistics industry has witnessed rapid growth, leading to significant carbon emissions and posing severe threats to the ecological environment. To investigate the spatiotemporal variations in carbon emissions in China's logistics industry, we conducted a correlation analysis using Moran's I index and a bivariate spatial autocorrelation model from 2010 to 2021. Additionally, we employed a geographically and temporally weighted regression model (GTWR) to examine the spatial heterogeneity of factors influencing provincial-level logistics-related carbon emissions. The results indicated that over the study period, there was a shift from insignificant spatial relationships to significant positive spatial correlations among provincial-level logistics carbon emissions in China. Furthermore, varying degrees of spatial clustering were observed. The findings regarding factor heterogeneity revealed that freight turnover volume, per capita GDP of the logistics industry, and infrastructure level exhibited positive spatial correlations with logistics-related carbon emissions, whereas energy intensity showed negative spatial correlations with such emissions. Comparing the results from the geographically weighted regression (GWR) and ordinary least squares regression (OLS), it was evident that the adjusted R-squared values for the OLS, GWR, and GTWR models were 0.541, 0.567, and 0.838, respectively. This suggests that our adopted GTWR model provided a superior fit and offered better explanations for spatiotemporal heterogeneity between various influencing factors and logistics-related carbon emissions. These research findings can serve as valuable references for formulating province-specific strategies to reduce carbon emissions within China's economy under its high-quality development context.

4.
Article in English | MEDLINE | ID: mdl-39200662

ABSTRACT

Queer young adults report significantly higher levels of anxiety and depression than their heterosexual counterparts, which is linked to sexual minority stress. Therefore, it is important to understand the coping strategies employed by this population to navigate minority stress and how coping strategies may impact mental health outcomes. Drawing from a U.S. national diverse sample of 387 queer young adults (ages 18-39 years), we analyzed descriptive results of 11 behavioral strategies to cope with minority stress and used ordered logistic and linear regression to examine the following objectives: the frequency of the use of each coping strategy, and the associations between each strategy and demographic characteristics as well as depression and anxiety. Results revealed that avoidance and talking with friends were the most frequently utilized coping strategies, while prayer/religious activities and counseling/psychotherapy/support groups were infrequently used. We examined utilization preferences of coping strategies across demographic factors (e.g., assigned sex at birth and sexual orientation). The use of counseling/psychotherapy/support group was positively associated with mental health symptoms, while exercise and mindfulness/mediation were associated with lower mental health symptoms. Our findings provide insights for mental health researchers and professionals in selecting appropriate coping strategies for queer young adults in prevention and intervention efforts.


Subject(s)
Adaptation, Psychological , Mental Health , Sexual and Gender Minorities , Stress, Psychological , Humans , Young Adult , Adult , Male , Female , Sexual and Gender Minorities/psychology , Sexual and Gender Minorities/statistics & numerical data , Adolescent , Stress, Psychological/psychology , Depression/psychology , Depression/epidemiology , Anxiety/psychology , Anxiety/epidemiology , United States
5.
Eat Behav ; 54: 101899, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38936286

ABSTRACT

Previous research identified four patterns of negative emotional eating in American and Chinese university students and proposed future directions (e.g., exploring potential differences in emotion regulation across patterns and replicating the patterns in a general, non-student population). Furthermore, prior research has not explored group differences in muscularity-oriented eating disorder symptomatology or psychosocial impairment. Therefore, the present study addressed these gaps in a sample of general Chinese adults, further testing group differences in typical and muscularity-oriented eating disorder symptomatology, psychosocial impairment, and emotion regulation difficulties across patterns of negative emotional eating. A total of 600 Chinese adults were recruited. Latent class analysis (LCA) was used. Results replicated the four patterns of negative emotional eating in previous research, including non-emotional eating (non-EE), emotional over- and under-eating (EOE-EUE), emotional over-eating (EOE), and emotional under-eating (EUE). Significant class differences were identified in eating disorder symptomatology, psychosocial impairment, and emotion regulation difficulties. Specifically, individuals with EOE and EOE-EUE patterns exhibited higher eating disorder symptomatology, higher psychosocial impairment, and more emotion regulation difficulties than those with non-EE and EUE patterns. Therefore, these two classes (i.e., EOE and EOE-EUE), especially the poorly researched EOE-EUE group, should be further examined to elucidate research and clinical applications. Furthermore, findings underscore the role of emotion regulation difficulties in further describing the differences across these negative emotional eating patterns, which can be considered in future interventions for reducing negative emotional eating.


Subject(s)
Emotional Regulation , Emotions , Feeding Behavior , Feeding and Eating Disorders , Humans , Female , Emotional Regulation/physiology , Male , Feeding and Eating Disorders/psychology , Adult , Young Adult , Emotions/physiology , Feeding Behavior/psychology , China , Adolescent
6.
Int J Mol Sci ; 25(7)2024 Mar 27.
Article in English | MEDLINE | ID: mdl-38612541

ABSTRACT

Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step in triacylglycerol synthesis. Understanding its substrate recognition mechanism may help to design drugs to regulate the production of glycerol lipids in cells. In this work, we investigate how the native substrate, glycerol-3-phosphate (G3P), and palmitoyl-coenzyme A (CoA) bind to the human GPAT isoform GPAT4 via molecular dynamics simulations (MD). As no experimentally resolved GPAT4 structure is available, the AlphaFold model is employed to construct the GPAT4-substrate complex model. Using another isoform, GPAT1, we demonstrate that once the ligand binding is properly addressed, the AlphaFold complex model can deliver similar results to the experimentally resolved structure in MD simulations. Following the validated protocol of complex construction, we perform MD simulations using the GPAT4-substrate complex. Our simulations reveal that R427 is an important residue in recognizing G3P via a stable salt bridge, but its motion can bring the ligand to different binding hotspots on GPAT4. Such high flexibility can be attributed to the flexible region that exists only on GPAT4 and not on GPAT1. Our study reveals the substrate recognition mechanism of GPAT4 and hence paves the way towards designing GPAT4 inhibitors.


Subject(s)
Glycerol , Glycerophosphates , Molecular Dynamics Simulation , Humans , Ligands , Glycerol-3-Phosphate O-Acyltransferase , Protein Isoforms , Phosphates
7.
Assessment ; : 10731911241247483, 2024 Apr 27.
Article in English | MEDLINE | ID: mdl-38676565

ABSTRACT

Screening for eating disorders (EDs) is an essential part of the prevention and intervention of EDs. Traditional screening methods mostly rely on predefined cutoff scores which have limitations of generalizability and may produce biased results when the cutoff scores are used in populations where the instruments or cutoff scores have not been validated. Compared to the traditional cutoff score approach, the diagnostic classification modeling (DCM) approach can provide psychometric and classification information simultaneously and has been used for diagnosing mental disorders. In the present study, we introduce DCM as an innovative and alternative approach to screening individuals at risk of EDs. To illustrate the practical utility of DCM, we provide two examples: one involving the application of DCM to examine probable ED status from the 12-item Short form of the Eating Disorder Examination-Questionnaire (EDE-QS) to screen probable thinness-oriented EDs and the Muscularity-Oriented Eating Test (MOET) to screen probable muscularity-oriented EDs.

8.
Ecotoxicol Environ Saf ; 276: 116289, 2024 May.
Article in English | MEDLINE | ID: mdl-38570269

ABSTRACT

The transmission of manure- and wastewater-borne antibiotic-resistant bacteria (ARB) to plants contributes to the proliferation of antimicrobial resistance in agriculture, necessitating effective strategies for preventing the spread of antibiotic resistance genes (ARGs) from ARB in the environment to humans. Nanomaterials are potential candidates for efficiently controlling the dissemination of ARGs. The present study investigated the abundance of ARGs in hydroponically grown garlic (Allium sativum L.) following nano-CeO2 (nCeO2) application. Specifically, root exposure to nCeO2 (1, 2.5, 5, 10 mg L-1, 18 days) reduced ARG abundance in the endosphere of bulbs and leaves. The accumulation of ARGs (cat, tet, and aph(3')-Ia) in garlic bulbs decreased by 24.2-32.5 % after nCeO2 exposure at 10 mg L-1. Notably, the lignification extent of garlic stem-disc was enhanced by 10 mg L-1 nCeO2, thereby accelerating the formation of an apoplastic barrier to impede the upward transfer of ARG-harboring bacteria to garlic bulbs. Besides, nCeO2 upregulated the gene expression related to alliin biosynthesis and increased allicin content by 15.9-16.2 %, promoting a potent antimicrobial defense for reducing ARG-harboring bacteria. The potential exposure risks associated with ARGs and Ce were evaluated according to the estimated daily intake (EDI). The EDI of ARGs exhibited a decrease exceeding 95 %, while the EDI of Ce remained below the estimated oral reference dose. Consequently, through stimulating physical and chemical defenses, nCeO2 contributed to a reduced EDI of ARGs and Ce, highlighting its potential for controlling ARGs in plant endosphere within the framework of nano-enabled agrotechnology.


Subject(s)
Cerium , Garlic , Garlic/genetics , Garlic/drug effects , Cerium/toxicity , Plant Roots/microbiology , Plant Roots/drug effects , Drug Resistance, Microbial/genetics , Plant Leaves , Anti-Bacterial Agents/pharmacology , Genes, Bacterial , Drug Resistance, Bacterial/genetics
9.
Appl Opt ; 63(9): 2340-2351, 2024 Mar 20.
Article in English | MEDLINE | ID: mdl-38568590

ABSTRACT

The storage and transmission of videos at high spatial resolution remain a great challenge in image-based optical techniques. The uncertainty of digital image correlation (DIC) was assessed following speckle video compression under High Efficiency Video Coding (HEVC/H.265). First, the evaluation criterion for the DIC accuracy affected by compression was provided. The stability of H.265 video compression in DIC was studied considering different compressed frames under different target quantization parameters (QPs) and compression ratios (CRs). The deformation uncertainty of the DIC itself as affected by H.265 video compression was further investigated through uniform translation and non-uniform sinusoidal deformation performance. Moreover, the optimized digital speckle pattern (DSP) was re-evaluated considering video compression-induced uncertainty. DSPs with parameters of different diameters and randomness were compressed using various QPs and CRs. In addition, DSP evaluation was performed under both translation and non-homogeneous deformation conditions. The feasibility of the re-optimized DSP under H.265 video compression was validated using a defective bending beam, and DSP videos with a speckle size of 8 pixels reached a high CR within an acceptable margin of error.

10.
Huan Jing Ke Xue ; 45(5): 3107-3118, 2024 May 08.
Article in Chinese | MEDLINE | ID: mdl-38629571

ABSTRACT

The rapid development of society and economy has resulted in a substantial increase in energy consumption, consequently exacerbating pollution issues. Current research predominantly focuses on energy-saving and emission reduction in road transportation within individual cities or the three major economic regions of China:the Yangtze River Delta, the Pearl River Delta, and the Beijing-Tianjin-Hebei Region. However, there is a dearth of studies addressing the southeastern coastal economic region. Located at the heart of China's southeastern coastal economic development, the provinces of Guangdong, Fujian, and Zhejiang unavoidably face challenges associated with energy consumption and emissions while pursuing economic growth. To address these challenges, this study employed a LEAP model to construct various scenarios for road transportation in the key coastal cities of Guangdong, Fujian, and Zhejiang from 2015 to 2035. These scenarios included a baseline scenario (BAU), an existing policy scenario (EPS), and an improved policy scenario (MPS). The MPS and EPS encompassed vehicle structure optimization (VSO), improved fuel economy (IFE), and reduced annual average mileage (RDM). By simulating and evaluating these scenarios, the energy-saving and emission reduction potentials of road transportation in the key coastal cities were assessed. The results indicated that, in the primary scenario, the MPS exhibited the most significant improvements in energy-saving, carbon reduction, and pollutant reduction effects. By 2035, the MPS achieved a remarkable 75% energy-saving rate compared to that in the baseline scenario, accompanied by reductions of 68%, 59%, 66%, 70%, and 64% in CO2, CO, NOx, PM2.5, and SO2 emissions, respectively. In the secondary scenario, the improved scenario of enhancing fuel economy achieved a notable 30% reduction in energy consumption. Additionally, the scenarios involving vehicle structure adjustment (yielding reductions of 36%, 30%, 36%, 26%, and 40%) and annual average mileage reduction (resulting in reductions of 37%, 37%, 36%, 37%, and 36%) demonstrated significant reductions in CO2, CO, NOx, PM2.5, and SO2 emissions.

11.
Body Image ; 49: 101697, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38460293

ABSTRACT

This study described muscularity teasing in both men and women and explored its associations with eating and body image disturbances in adults from China. A total of 900 Chinese adults (50% women) were recruited online. Correlation and regression analyses were conducted to examine the relationships between muscularity teasing and a battery of measures on eating and body image disturbances. Gender differences in the associations were examined. Men reported more muscularity teasing than women (31.6% men vs. 15.6% women; χ2(1,N = 900) = 31.99, p < .001). Muscularity teasing was significantly and positively correlated with all measures in both men and women. Muscularity teasing explained significant, unique variance in all measures for men and women, except for body fat dissatisfaction in women, beyond covariates (i.e., age, body mass index, and weight teasing). The relationships between muscularity teasing and eating and body image disturbances were generally stronger in men than women. Findings further suggest that muscularity teasing is an important factor related to eating and body image disturbances in men and women, but muscularity teasing might be more detrimental to men's eating behaviors and body image. Future research is needed to further explore the directionality and mechanisms of the links between muscularity teasing and eating and body image disturbances.


Subject(s)
Body Image , Feeding Behavior , Humans , Male , Female , Adult , China , Body Image/psychology , Young Adult , Feeding Behavior/psychology , Body Dissatisfaction/psychology , Middle Aged , Sex Factors , Body Mass Index , Adolescent , Body Dysmorphic Disorders/psychology , Asian People/psychology , Surveys and Questionnaires , East Asian People
12.
Body Image ; 49: 101698, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38489965

ABSTRACT

Extensions of objectification theory to pregnant women are few and continued research is needed to better understand the psychological consequences of significant changes to physical appearance during pregnancy. Specific interests in this area include functionality appreciation which may be particularly relevant to pregnancy. Research in this area is also lacking representation of non-Western cultural contexts. To this end, we employed an online survey to assess objectification theory and functionality appreciation in Chinese pregnant women (N = 345). Correlations showed that higher body surveillance and body shame were associated with higher disordered eating and psychological distress, and higher functionality appreciation was associated with lower body surveillance, body shame, and disordered eating. Mediation analyses suggested that higher body surveillance was associated with higher body shame which, in turn, was associated with higher disordered eating and psychological distress. Main effects suggested a negative association between functionality appreciation and body shame, but moderation analyses suggested that higher functionality appreciation strengthened the positive association between body surveillance and body shame. Findings underscore objectification theory as a useful framework to understand eating and body image disturbances and psychological distress in Chinese pregnant women and outline future directions to clarify the temporal nature of these associations and the precise role of functionality appreciation.


Subject(s)
Body Image , Feeding and Eating Disorders , Pregnant Women , Self Concept , Shame , Humans , Female , Pregnancy , Body Image/psychology , Adult , Pregnant Women/psychology , Pregnant Women/ethnology , Feeding and Eating Disorders/psychology , Feeding and Eating Disorders/ethnology , China/ethnology , Young Adult , Surveys and Questionnaires , Psychological Distress , Stress, Psychological/psychology , Stress, Psychological/ethnology , Adolescent , East Asian People
13.
Mol Psychiatry ; 29(5): 1253-1264, 2024 May.
Article in English | MEDLINE | ID: mdl-38228891

ABSTRACT

The pathophysiology of autism spectrum disorders (ASDs) is causally linked to postsynaptic scaffolding proteins, as evidenced by numerous large-scale genomic studies [1, 2] and in vitro and in vivo neurobiological studies of mutations in animal models [3, 4]. However, due to the distinct phenotypic and genetic heterogeneity observed in ASD patients, individual mutation genes account for only a small proportion (<2%) of cases [1, 5]. Recently, a human genetic study revealed a correlation between de novo variants in FERM domain-containing-5 (FRMD5) and neurodevelopmental abnormalities [6]. In this study, we demonstrate that deficiency of the scaffolding protein FRMD5 leads to neurodevelopmental dysfunction and ASD-like behavior in mice. FRMD5 deficiency results in morphological abnormalities in neurons and synaptic dysfunction in mice. Frmd5-deficient mice display learning and memory dysfunction, impaired social function, and increased repetitive stereotyped behavior. Mechanistically, tandem mass tag (TMT)-labeled quantitative proteomics revealed that FRMD5 deletion affects the distribution of synaptic proteins involved in the pathological process of ASD. Collectively, our findings delineate the critical role of FRMD5 in neurodevelopment and ASD pathophysiology, suggesting potential therapeutic implications for the treatment of ASD.


Subject(s)
Autism Spectrum Disorder , Disease Models, Animal , Membrane Proteins , Neurodevelopmental Disorders , Animals , Mice , Autism Spectrum Disorder/genetics , Autism Spectrum Disorder/metabolism , Neurodevelopmental Disorders/genetics , Neurodevelopmental Disorders/metabolism , Membrane Proteins/genetics , Membrane Proteins/metabolism , Male , Neurons/metabolism , Behavior, Animal/physiology , Cytoskeletal Proteins/genetics , Cytoskeletal Proteins/metabolism , Mice, Knockout , Autistic Disorder/genetics , Autistic Disorder/metabolism , Mice, Inbred C57BL , Social Behavior , Stereotyped Behavior , Synapses/metabolism , Female
14.
Sci Total Environ ; 917: 170430, 2024 Mar 20.
Article in English | MEDLINE | ID: mdl-38281632

ABSTRACT

The leaping forward of the economy has promoted the rapid growth of road traffic demand, resulting in the carbon emissions of road traffic increasing significantly. It is well known that a one-size-fits-all emission reduction policy is not feasible. Therefore, conducting an investigation on the carbon emissions of all provincial-level regions within a country can assist the government in formulating carbon emission policies at a macro level tailored to different regions. In this study, the whole provincial-level administrative regions in the mainland of China were selected to quantify the carbon emissions of road traffic, and the carbon emissions from 2006 to 2021 were obtained by employing the top-down model. What's more, spatiotemporal characteristics of road transportation carbon emissions in those regions were explored based on Moran's I spatial autocorrelation method. In addition, the LMDI model was constructed based on five driving factors, namely energy intensity, energy consumption intensity, industrial scale, economic development, and population size, and the decomposition analysis of driving factors is carried out. The results show that carbon emissions from road traffic in all provincial regions showed an overall rising trend in the research period, with an average annual growth rate of 11.83 %. The distribution of road transportation carbon emissions exhibited an east-high, west-low distribution, with significantly higher emissions in the eastern and coastal regions compared to inland areas, additionally, China's seven geographical regions showed an initial rapid increase in carbon emissions followed by a stable growth trend. Secondly, five types of spatial clustering were identified of carbon emissions within provincial regions. Thirdly, the impacts of energy intensity and industrial scale were detrimental to road transportation carbon emissions, whereas economic development, energy consumption intensity, and population size had contrasting effects. Implications according to the above conclusions were put forward, aiming to provide guidance for the sustainable development of road transportation and expediting the achievement of the "carbon peaking and carbon neutrality" objective.

15.
Front Sleep ; 22023.
Article in English | MEDLINE | ID: mdl-38077744

ABSTRACT

Rationale: Obstructive sleep apnea (OSA) is associated with metabolic dysfunction, including progression of nonalcoholic fatty liver disease (NAFLD). Chronic intermittent hypoxia (IH) as a model of OSA worsens hepatic steatosis and fibrosis in rodents with diet induced obesity. However, IH also causes weight loss, thus complicating attempts to co-model OSA and NAFLD. We sought to determine the effect of various durations of IH exposure on metabolic and liver-related outcomes in a murine NAFLD model. We hypothesized that longer IH duration would worsen the NAFLD phenotype. Methods: Male C57BL/6J mice (n = 32) were fed a high trans-fat diet for 24 weeks, to induce NAFLD with severe steatohepatitis. Mice were exposed to an IH profile modeling severe OSA, for variable durations (0, 6, 12, or 18 weeks). Intraperitoneal glucose tolerance test was measured at baseline and at six-week intervals. Liver triglycerides, collagen and other markers of NAFLD were measured at sacrifice. Results: Mice exposed to IH for 12 weeks gained less weight (p = 0.023), and had lower liver weight (p = 0.008) relative to room air controls. These effects were not observed in the other IH groups. IH of longer duration transiently worsened glucose tolerance, but this effect was not seen in the groups exposed to shorter durations of IH. IH exposure for 12 or 18 weeks exacerbated liver fibrosis, with the largest increase in hepatic collagen observed in mice exposed to IH for 12 weeks. Discussion: Duration of IH significantly impacts clinically relevant outcomes in a NAFLD model, including body weight, fasting glucose, glucose tolerance, and liver fibrosis.

16.
Article in English | MEDLINE | ID: mdl-38095957

ABSTRACT

Free time in a working memory task often improves the recall performances of the to-be-remembered items. It is still debated whether the free-time effect in working memory is purely proactive, purely retroactive, or both proactive and retroactive. In the present study, we used the single-gap paradigm to explore this question. In Experiment 1, we measured the gap-length effect (i.e., the difference in memory performance elicited by the gap-length difference) under three long-short-gap combinations (i.e., 2,500 ms/100 ms, 2,500 ms/500 ms, 2,500 ms/1,000 ms). Proactive effects have been observed in all the three combinations whereas retroactive effects have only been found in two of them (i.e., 2,500 ms/100 ms, 2,500 ms/500 ms). To rule out the possibility that the retroactive effects found in Experiment 1 were simply due to the temporal grouping caused by the gap, in Experiment 2, the 2,500 ms/500 ms combination was retested, with the memory materials being changed from letters (the material used in Experiment 1) to words. The results showed that the range of the retroactive effect (i.e., the number of affected memory items prior to the gap) increased when the memory material changed from letters to words, which cannot be explained by temporal grouping. Taken together, the two experiments provided solid evidence that free time in working memory could produce both retroactive and proactive effects that cannot be explained by temporal grouping. These findings also provide insight into the underlying mechanism of working memory, for example, whether rehearsal would occur during the free time. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

17.
BMC Biol ; 21(1): 235, 2023 10 25.
Article in English | MEDLINE | ID: mdl-37880634

ABSTRACT

BACKGROUND: Severe peripheral nerve injury (PNI) often leads to significant movement disorders and intractable pain. Therefore, promoting nerve regeneration while avoiding neuropathic pain is crucial for the clinical treatment of PNI patients. However, established animal models for peripheral neuropathy fail to accurately recapitulate the clinical features of PNI. Additionally, researchers usually investigate neuropathic pain and axonal regeneration separately, leaving the intrinsic relationship between the development of neuropathic pain and nerve regeneration after PNI unclear. To explore the underlying connections between pain and regeneration after PNI and provide potential molecular targets, we performed single-cell RNA sequencing and functional verification in an established rat model, allowing simultaneous study of the neuropathic pain and axonal regeneration after PNI. RESULTS: First, a novel rat model named spared nerve crush (SNC) was created. In this model, two branches of the sciatic nerve were crushed, but the epineurium remained unsevered. This model successfully recapitulated both neuropathic pain and axonal regeneration after PNI, allowing for the study of the intrinsic link between these two crucial biological processes. Dorsal root ganglions (DRGs) from SNC and naïve rats at various time points after SNC were collected for single-cell RNA sequencing (scRNA-seq). After matching all scRNA-seq data to the 7 known DRG types, we discovered that the PEP1 and PEP3 DRG neuron subtypes increased in crushed and uncrushed DRG separately after SNC. Using experimental design scRNA-seq processing (EDSSP), we identified Adcyap1 as a potential gene contributing to both pain and nerve regeneration. Indeed, repeated intrathecal administration of PACAP38 mitigated pain and facilitated axonal regeneration, while Adcyap1 siRNA or PACAP6-38, an antagonist of PAC1R (a receptor of PACAP38) led to both mechanical hyperalgesia and delayed DRG axon regeneration in SNC rats. Moreover, these effects can be reversed by repeated intrathecal administration of PACAP38 in the acute phase but not the late phase after PNI, resulting in alleviated pain and promoted axonal regeneration. CONCLUSIONS: Our study reveals that Adcyap1 is an intrinsic protective factor linking neuropathic pain and axonal regeneration following PNI. This finding provides new potential targets and strategies for early therapeutic intervention of PNI.


Subject(s)
Axons , Neuralgia , Pituitary Adenylate Cyclase-Activating Polypeptide , Animals , Rats , Axons/physiology , Ganglia, Spinal/physiology , Nerve Regeneration/genetics , Neuralgia/genetics , Neurons , Pituitary Adenylate Cyclase-Activating Polypeptide/genetics , Protective Factors , Rats, Sprague-Dawley , Sequence Analysis, RNA
18.
Body Image ; 47: 101627, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37742536

ABSTRACT

The Muscularity Bias Internalization Scale (MBIS) captures an individual's endorsement of stereotypical beliefs about muscularity and engagement in self-stigmatizing evaluations about their muscularity. The MBIS has been validated in Chinese men and Lebanese men and women, showing strong internal consistency reliability and construct validity. Because muscularity-related body image concerns are present in Chinese women, there is a need for research to validate the MBIS in Chinese women. The present study examined the factor structure and psychometric properties of the MBIS in a sample of Chinese women. Exploratory factor analysis (n = 300) identified a two-factor structure which showed adequate model fit in confirmatory factor analysis (n = 300), with χ2(76) = 294.63 (p < .001), CFI = 0.98, TLI = 0.98, and SRMR = 0.05. Results also showed that the MBIS in women had adequate internal consistency, two-week test-retest reliability, and good construct validity. Findings suggest that the MBIS is a useful tool for assessing muscularity bias internalization, a potentially important risk factor for muscularity-oriented eating and body image disturbances.


Subject(s)
Body Image , Muscle, Skeletal , Male , Humans , Female , Body Image/psychology , Reproducibility of Results , Psychometrics , China , Surveys and Questionnaires
19.
Nurse Educ Today ; 130: 105926, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37591112

ABSTRACT

BACKGROUND: Strategies to improve the teaching effectiveness of nursing research courses are a fundamental objective of contemporary nursing educators. The role practice method is the sum of ways, means, and procedures used to perform role-specific practical learning activities through the adaptation of concepts, models and subjective abilities in an authentic environment. This technique enhances teaching effectiveness by encouraging students to actively participate in practice. OBJECTIVE: The main aim of this study was to explore the effectiveness of the role practice approach within the framework of nursing research courses and provide guidance for subsequent teaching efforts. METHODS: The purposive sampling method was used to recruit 16 students who participated in teaching of the role practice approach and completed all tasks set within the nursing research course in the third year of the undergraduate nursing program of a comprehensive university in south China. Data obtained from semi-structured interviews were analyzed using Colaizzi's seven-step analysis method. RESULTS: Three themes were evaluated, specifically, self-improvement, self-inadequacy and course optimization. CONCLUSION: The role practice method is effective in teaching nursing research courses and can enhance the ability of students to conduct research activities. However, deficiencies in the implementation plan exist that need further revision.


Subject(s)
Education, Nursing, Baccalaureate , Nursing Research , Students, Nursing , Humans , Exercise , Qualitative Research
20.
J Homosex ; : 1-21, 2023 Aug 29.
Article in English | MEDLINE | ID: mdl-37643388

ABSTRACT

There is a paucity of research on the links between gay dating apps usage and body dissatisfaction and disordered eating, especially for muscularity dissatisfaction and muscularity-oriented disordered eating in non-Western contexts. Thus, this study aimed to evaluate the associations between gay dating apps usage, body image inflexibility, body dissatisfaction, and disordered eating with the inclusion of both body fat and muscularity dissatisfaction and both thinness-and muscularity-oriented disordered eating in a sample of Chinese young gay men. A total of 247 Chinese young gay men (mean age: 21.92 ± 2.74 years) were recruited. Gay dating apps usage, body fat dissatisfaction, muscularity dissatisfaction, body image inflexibility, and thinness-and muscularity-oriented disordered eating were evaluated. Pearson correlation and mediation analyses were conducted. Gay dating apps usage was positively correlated with body fat dissatisfaction (r = .20, p = .002), muscularity dissatisfaction (r = .17, p = .006), thinness-oriented disordered eating (r = .21, p < .001), and muscularity-oriented disordered eating (r = .29, p < .001), and these relationships could be mediated by body image inflexibility. Findings support technologically-informed prevention and intervention strategies for eating and body image disturbances in gay men in the Chinese context.

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